s.grimaldi

TL2 Moderator · Salvador

Contributes reviews on supplier material. Based in Salvador.

Joined 22 November 2024 · last posted 23h

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Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #31 · Evidence › Meta-analyses · 27 Jul 2026 · 0 likes Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion criteria. If the criteria are too broad, apples and oranges get pooled. If they are…
Distinguishing a red flag from an inconvenience — a second dataset Replied, post #8 · Sourcing › Red flags · 23 Jul 2026 · 0 likes On post #4 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you…
Journal club: what we got wrong in an earlier session Replied, post #102 · Evidence › Journal club · 20 Jul 2026 · 15 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
Insomnia at a dose step: reported experiences — the long version Replied, post #47 · Wellbeing › Sleep · 15 Jul 2026 · 26 likes Stimulants and sleep: if supplementing with caffeine or other stimulants for energy during weight loss, timing and dose matter for sleep. Evening stimulant use…
Coming back to: Batch date after test date, and other internal inconsistencies Replied, post #13 · Analytics › COA interpretation · 15 Jul 2026 · 2 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Here for the analytics and not much else Replied, post #20 · Lounge › Introductions · 11 Jul 2026 · 1 like Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Endotoxin and why it is a separate question from purity — what changed since Replied, post #73 · Analytics › Impurities & related substances · 10 Jul 2026 · 14 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
What a regulator's shortage notice actually authorises Replied, post #5 · Sourcing › Regulatory · 7 Jul 2026 · 16 likes Approval versus licensing: a compound can be approved for a specific indication in one country and not approved at all in another. Tracking jurisdictional approval is…
GLP-1 receptor distribution: central and peripheral Replied, post #83 · Pharmacology › Receptor biology · 4 Jul 2026 · 11 likes Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
Prescription requirements and telehealth models — a second dataset Replied, post #76 · Sourcing › Regulatory · 23 Jun 2026 · 31 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #72 · Compounds › Semaglutide · 21 Jun 2026 · 1 like post #71 answers the question as asked. The question underneath it is different. The opalescent appearance in semaglutide solutions is occasionally noted and the…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #7 · Compounds › Retatrutide · 17 Jun 2026 · 0 likes TRIUMPH is phase 3 and it is ongoing. No phase 3 results exist. Nothing should be attributed to TRIUMPH because the trial has not finished. When it does, this page will…