s.grimaldi

TL2 Moderator · Salvador

Contributes reviews on supplier material. Based in Salvador.

Joined 22 November 2024 · last posted 23h

95 posts, newest first. Showing up to 150.

Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #31 · Evidence › Meta-analyses · 27 Jul 2026 · 0 likes Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion criteria. If the criteria are too broad, apples and oranges get pooled. If they are…
Distinguishing a red flag from an inconvenience — a second dataset Replied, post #8 · Sourcing › Red flags · 23 Jul 2026 · 0 likes On post #4 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you…
Journal club: what we got wrong in an earlier session Replied, post #102 · Evidence › Journal club · 20 Jul 2026 · 15 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
Insomnia at a dose step: reported experiences — the long version Replied, post #47 · Wellbeing › Sleep · 15 Jul 2026 · 26 likes Stimulants and sleep: if supplementing with caffeine or other stimulants for energy during weight loss, timing and dose matter for sleep. Evening stimulant use…
Coming back to: Batch date after test date, and other internal inconsistencies Replied, post #13 · Analytics › COA interpretation · 15 Jul 2026 · 2 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Here for the analytics and not much else Replied, post #20 · Lounge › Introductions · 11 Jul 2026 · 1 like Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Endotoxin and why it is a separate question from purity — what changed since Replied, post #73 · Analytics › Impurities & related substances · 10 Jul 2026 · 14 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
What a regulator's shortage notice actually authorises Replied, post #5 · Sourcing › Regulatory · 7 Jul 2026 · 16 likes Approval versus licensing: a compound can be approved for a specific indication in one country and not approved at all in another. Tracking jurisdictional approval is…
GLP-1 receptor distribution: central and peripheral Replied, post #83 · Pharmacology › Receptor biology · 4 Jul 2026 · 11 likes Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
Prescription requirements and telehealth models — a second dataset Replied, post #76 · Sourcing › Regulatory · 23 Jun 2026 · 31 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #72 · Compounds › Semaglutide · 21 Jun 2026 · 1 like post #71 answers the question as asked. The question underneath it is different. The opalescent appearance in semaglutide solutions is occasionally noted and the…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #7 · Compounds › Retatrutide · 17 Jun 2026 · 0 likes TRIUMPH is phase 3 and it is ongoing. No phase 3 results exist. Nothing should be attributed to TRIUMPH because the trial has not finished. When it does, this page will…
Request: a per-category review queue Replied, post #40 · Meta › Feature requests · 16 Jun 2026 · 10 likes Requests for platform and documentation features, with the reasoning that justifies them. If you think the site would be better with a feature, suggest it with enough…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #73 · Devices › Syringes & needles · 15 Jun 2026 · 30 likes Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a…
Micronutrient adequacy at low total intake Replied, post #76 · Nutrition & Training › Protein & intake · 12 Jun 2026 · 3 likes Fibre: adequate fibre intake supports fullness and gut motility, both of which matter during the gastrointestinal effects of these compounds. High fibre on top of…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #98 · Practice › Storage & stability · 8 Jun 2026 · 12 likes Beyond-use dating: the date after which a prepared solution should not be used. It is an estimate based on how fast the solution degrades under stated storage, not on…
Chain of custody for a sample you posted yourself Replied, post #2 · Sourcing › Independent verification · 4 Jun 2026 · 2 likes Medutest: combined purity and identity reporting. Appears throughout vendor documentation. Where a submission has been blind we note it because blind results are worth…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #11 · Pharmacology › Pharmacokinetics · 26 May 2026 · 21 likes Albumin binding: semaglutide binds albumin through a fatty side chain, which sequesters the free form and extends the half-life. Tirzepatide also has albumin binding…
Reading a trial's population section before its results Replied, post #53 · Evidence › Trials · 25 May 2026 · 25 likes I read post #51 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Moderation log format change Replied, post #55 · Meta › Announcements · 22 May 2026 · 0 likes Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions clarifying what was announced.
Revisiting: Journal club: SURMOUNT-1, read without the press release Replied, post #46 · Evidence › Journal club · 16 May 2026 · 12 likes I read post #44 twice before replying, because I had assumed the opposite. SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective…
Revisiting: The arithmetic of an intermediate dose between two label steps Replied, post #9 · Practice › Dosing & titration · 14 May 2026 · 0 likes On post #5 — agreed on the reasoning, with one qualification. How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a…
[2026 update] Currency conversion and the cost you did not see Replied, post #18 · Sourcing › Payments · 11 May 2026 · 0 likes post #17 answers the question as asked. The question underneath it is different. Documentation and tax implications: payments you make for compounds might have…
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #25 · Analytics › Home & field testing · 9 May 2026 · 5 likes I read post #23 twice before replying, because I had assumed the opposite. Sample handling matters: if a sample is contaminated or degraded before testing, the test…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #55 · Evidence › Journal club · 5 May 2026 · 29 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Coming back to: Time to steady state after a dose increase Replied, post #46 · Pharmacology › Pharmacokinetics · 4 May 2026 · 8 likes Fasting requirement for oral semaglutide: food and large fluid volumes reduce absorption. The fasting window (30 minutes before and 30 minutes after) is designed to…
Why the timeline is on the right and not the left — what changed since Replied, post #29 · Meta › Site feedback · 1 May 2026 · 30 likes On post #25 — agreed on the reasoning, with one qualification. Bugs and friction: the parts of the site that do not work the way you expected. Report them specifically…
Historical amylin analogues and what happened to them Replied, post #4 · Compounds › Cagrilintide & amylin analogues · 30 Apr 2026 · 3 likes Reading the phase 2 paper: it establishes tolerability and efficacy in a selected population on a defined dose escalation. It does not establish the lowest effective…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #28 · Practice › Reconstitution · 28 Apr 2026 · 17 likes Over-dilution: if your target dose is 0.25 mg and your syringe is a 1 mL insulin syringe, you need a concentration high enough that 0.25 mg fits on the scale. A 0.25…
Forced degradation studies: designing one that is informative Replied, post #45 · Analytics › Method validation · 28 Apr 2026 · 1 like post #44 answers the question as asked. The question underneath it is different. Linearity: the detector response is proportional to compound concentration across the…
Private prescribing in the UK: what is actually involved Started this topic · Regional › UK & Ireland · 17 Apr 2026 · 27 likes On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. A coverage question with the paperwork…
List price versus negotiated price versus what you pay Replied, post #87 · Access › Pricing · 15 Apr 2026 · 23 likes post #86 is right about the mechanism and I think understates the practical bit. Insurance tier placement: a compound might be covered but on a higher tier (higher…
List price versus negotiated price versus what you pay Replied, post #62 · Access › Pricing · 13 Apr 2026 · 8 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #2 · Wellbeing › Sleep · 21 Mar 2026 · 6 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Second pass at: Robustness: the parameters worth deliberately varying Replied, post #54 · Analytics › Method validation · 8 Mar 2026 · 25 likes This follows post #51 rather than contradicting it. Accuracy: the method measures what you intend to measure. For purity methods, this is tested by spike-and-recover…
Adolescents: a distinct evidence base — one year on Replied, post #72 · Clinical › Special populations · 7 Mar 2026 · 0 likes post #71 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #108 · Access › Pricing · 6 Mar 2026 · 23 likes Discount programmes and coupons: manufacturers often offer coupons that reduce out-of-pocket costs if insurance is not covering or is covering at a high copay. These…
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #21 · Start Here › Welcome · 5 Mar 2026 · 4 likes post #20 answers the question as asked. The question underneath it is different. Introducing yourself is fine and requires no question. Post in this subcategory,…
Common supplements people ask about, assessed one at a time — a second dataset Replied, post #60 · Practice › Interactions · 1 Mar 2026 · 0 likes Picking up post #57: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #34 · Compounds › Cagrilintide & amylin analogues · 1 Mar 2026 · 6 likes On post #30 — agreed on the reasoning, with one qualification. Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and promotes satiety…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #32 · Analytics › Mass spectrometry · 9 Feb 2026 · 7 likes Picking up post #29: that is the part I would want checked first. Tandem mass spectrometry: MS/MS fragments the molecular ion and uses fragment masses to confirm…
Trifluoroacetate content and its consequences Replied, post #87 · Analytics › Impurities & related substances · 5 Feb 2026 · 18 likes I read post #85 twice before replying, because I had assumed the opposite. Related substances: compounds chemically related to the target peptide but not the target…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #89 · Compounds › Oral incretins · 13 Dec 2025 · 0 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
Tracking that stops updating and then resumes Replied, post #54 · Sourcing › Logistics · 8 Dec 2025 · 8 likes This follows post #51 rather than contradicting it. Documentation after arrival: photograph the parcel and its contents on arrival. If something later turns out wrong…
Citation sweep results: how many references did not say what was claimed Replied, post #11 · Meta › Wiki maintenance · 28 Nov 2025 · 26 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #49 · Sourcing › Regulatory · 25 Nov 2025 · 4 likes post #48 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #53 · Wellbeing › Mental health · 22 Nov 2025 · 11 likes Picking up post #50: that is the part I would want checked first. Body image and weight loss: large weight loss changes a person's relationship with their body in ways…
Availability by country, dated, with primary sources Replied, post #64 · Access › International · 17 Nov 2025 · 1 like Licensed prescribing: where a compound is approved, prescribing is restricted to licensed prescribers. Where it is not approved, the legality of possession and use is…
The headache that turns out to be dehydration Replied, post #33 · Nutrition & Training › Hydration & electrolytes · 24 Oct 2025 · 0 likes Constipation and hydration: dehydration makes constipation worse. Increasing fluid intake is the first intervention for constipation alongside other measures.
Pinch or no pinch, and how needle length changes the answer Replied, post #123 · Practice › Administration · 22 Oct 2025 · 21 likes Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less…
Substitution between formats during a shortage Replied, post #76 · Access › Shortages · 16 Oct 2025 · 12 likes This follows post #73 rather than contradicting it. Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are…
Second pass at: Programming during a large energy deficit Replied, post #37 · Nutrition & Training › Resistance training · 12 Oct 2025 · 0 likes Worth separating two things that post #33 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #73 · Compounds › Retatrutide · 1 Sep 2025 · 25 likes Retatrutide is investigational. Anything obtained outside a trial is by definition research-use-only material with no human-use authorisation. This site will state that…
Persistent vomiting and the threshold for seeking help Replied, post #22 · Safety › Adverse events · 22 Aug 2025 · 1 like On post #18 — agreed on the reasoning, with one qualification. Severe gastrointestinal events: persistent vomiting, abdominal pain out of proportion, or signs of bowel…
Reading a supplier's product description as a marketing document Replied, post #60 · Compounds › Other compounds · 21 Aug 2025 · 1 like post #59 answers the question as asked. The question underneath it is different. Reading a supplier's product description as a marketing document: that is exactly what…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #28 · Analytics › HPLC & UHPLC · 6 Aug 2025 · 14 likes Worth separating two things that post #24 runs together. Reversed-phase separates on hydrophobicity. A peptide is retained on a non-polar stationary phase and eluted by…
A ten-fold dose error caught before injection — one year on Replied, post #142 · Devices › Syringes & needles · 5 Aug 2025 · 3 likes Picking up post #139: that is the part I would want checked first. Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02…
How to research a compound with no human data without deceiving yourself Replied, post #53 · Compounds › Other compounds · 1 Aug 2025 · 15 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption or…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #25 · Compounds › Secretagogues & GH axis · 31 Jul 2025 · 0 likes CJC-1295 with and without DAC: the version with a drug affinity complex binds albumin covalently and persists for days. The version without it does not persist.…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #93 · Wellbeing › Mental health · 20 Jul 2025 · 5 likes Body image and weight loss: large weight loss changes a person's relationship with their body in ways that can be psychologically complex. Some of that is positive;…
Second pass at: Retatrutide mass and identity: what a report should show Replied, post #64 · Compounds › Retatrutide · 9 Jun 2025 · 30 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Pre-registering a personal experiment, seriously Replied, post #112 · Research Methods › N-of-1 designs · 4 Jun 2025 · 0 likes Designing a personal experiment that could actually change your mind: that is the standard for an n-of-1 design. An experiment designed so that any result confirms what…
Pre-registering a personal experiment, seriously Replied, post #52 · Research Methods › N-of-1 designs · 30 May 2025 · 0 likes Coming back to post #50, because the follow-up matters more than the original answer. Designing a personal experiment that could actually change your mind: that is the…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #115 · Sourcing › Independent verification · 18 May 2025 · 11 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
Second pass at: Designing a personal experiment that could change your mind Replied, post #10 · Research Methods › N-of-1 designs · 17 May 2025 · 5 likes post #9 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Adjudicated events and why the definition matters — the long version Replied, post #124 · Evidence › Trials · 28 Apr 2025 · 3 likes Worth separating two things that post #120 runs together. Intent-to-treat versus per-protocol: ITT includes everyone assigned regardless of whether they took the drug.…
Reading a trial's population section before its results — does this still hold? Replied, post #27 · Evidence › Trials · 21 Apr 2025 · 0 likes Intent-to-treat versus per-protocol: ITT includes everyone assigned regardless of whether they took the drug. Per-protocol includes only those who completed it as…
Review: a draft on reconstitution arithmetic, with objections Replied, post #106 · Documentation › Doc review · 14 Apr 2025 · 7 likes On post #102 — agreed on the reasoning, with one qualification. Evidence synthesis requests: if you think a page should summarise the state of evidence on a question,…
Checking someone else's arithmetic: a worked example thread Replied, post #29 · Practice › Reconstitution · 13 Mar 2025 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Validating a method you did not develop — does this still hold? Replied, post #96 · Analytics › Method validation · 10 Mar 2025 · 3 likes Worth separating two things that post #92 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Second pass at: Cross-border purchase within the EU: the actual rules Replied, post #84 · Access › International · 7 Mar 2025 · 0 likes Coming back to post #82, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
A page that has drifted out of date and needs a maintainer Replied, post #69 · Documentation › Wiki requests · 26 Feb 2025 · 0 likes Flag a page that has drifted: if you notice a maintained page has information that is outdated (dates that have passed, regulatory changes, new evidence) post a flag so…
Second pass at: Manufacturer assistance programmes and their eligibility rules Replied, post #9 · Access › Pricing · 26 Feb 2025 · 3 likes Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #14 · Practice › Reconstitution · 21 Feb 2025 · 1 like Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #70 · Evidence › Meta-analyses · 7 Feb 2025 · 1 like Number needed to treat from a meta-analysis: can be computed from the pooled estimate if the baseline risk is specified. More interpretable than pooled relative effects.
Criticising the method without criticising the authors Replied, post #36 · Evidence › Study critique · 1 Feb 2025 · 12 likes I read post #34 twice before replying, because I had assumed the opposite. Bias towards the null and bias away from the null: different criticisms have different…
[2026 update] What the GIP component of tirzepatide is thought to contribute, and how… Replied, post #9 · Compounds › Tirzepatide · 1 Feb 2025 · 3 likes I read post #7 twice before replying, because I had assumed the opposite. The GIP component: GIP receptor agonism is thought to amplify the GLP-1 effect on satiety and…
Telehealth prescribing models in the US Replied, post #45 · Regional › North America · 13 Jan 2025 · 16 likes Prior authorisation, step therapy, and exclusion of weight-management indications from coverage are common access barriers. The denial letter tells you which barrier…
Building a sensible monitoring schedule with your prescriber Replied, post #78 · Clinical › Bloodwork · 22 Dec 2024 · 8 likes Coming back to post #76, because the follow-up matters more than the original answer. Reference intervals: constructed to contain the central 95% of a reference…
Building a sensible monitoring schedule with your prescriber Started this topic · Clinical › Bloodwork · 17 Dec 2024 · 25 likes Building a sensible monitoring schedule with your prescriber — setting out what I have, and where I think it stops being reliable. General question, not a request for…
Second pass at: Regression to the mean in progress reports Started this topic · Research Methods › Statistics · 12 Dec 2024 · 1 like Second pass at: Regression to the mean in progress reports Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N…
Gallbladder disease risk with rapid weight loss Replied, post #37 · Clinical › Comorbidities · 29 Nov 2024 · 0 likes I read post #35 twice before replying, because I had assumed the opposite. Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for…
Asking about a compound your prescriber has not heard of — one year on Replied, post #5 · Clinical › Prescriber conversations · 18 Nov 2024 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Journal club: SURMOUNT-1, read without the press release Replied, post #14 · Evidence › Journal club · 14 Nov 2024 · 12 likes STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially…
SURPASS-2 and the comparator dose question that will not go away Replied, post #55 · Compounds › Tirzepatide · 13 Nov 2024 · 0 likes Half-life difference: tirzepatide is about 5 days versus semaglutide's week-long. Practically, that means steady state is reached slightly faster and the post-dose…
Food noise reducing and the disorientation that can follow Replied, post #32 · Wellbeing › Mental health · 1 Nov 2024 · 0 likes post #31 answers the question as asked. The question underneath it is different. Social and relationship impacts: weight change affects how others perceive and interact…
Request: a diff view for wiki revisions Replied, post #20 · Meta › Feature requests · 29 Oct 2024 · 24 likes Effort estimation: some features are trivial to implement; others are substantial work. Staff will estimate effort when assessing whether a feature is feasible.
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #120 · Clinical › Bloodwork · 18 Oct 2024 · 12 likes post #119 answers the question as asked. The question underneath it is different. Liver enzymes: elevation does not specify cause. ALT and AST can rise from many…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #38 · Access › Shortages · 10 Oct 2024 · 7 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.
Irish differences from the UK position Replied, post #22 · Regional › UK & Ireland · 5 Oct 2024 · 32 likes NHS access has been restricted by commissioning criteria, not by licensing. Specialist weight-management services in many areas require prior weight-loss attempts, BMI…
Correlation in a self-tracked dataset: what it can support Replied, post #114 · Research Methods › Statistics · 24 Aug 2024 · 25 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Pen mechanics when the cartridge is nearly empty Replied, post #2 · Devices › Pens & autoinjectors · 9 Aug 2024 · 0 likes Picking up the opening post: that is the part I would want checked first. Dose counters: pens show the remaining number of doses. When the counter reaches zero, the pen…
Second pass at: Sodium, potassium and magnesium when intake drops Replied, post #26 · Nutrition & Training › Hydration & electrolytes · 5 Aug 2024 · 14 likes post #25 is right about the mechanism and I think understates the practical bit. Exercise and electrolyte losses: sweating during exercise increases sodium and…
Second pass at: Journal club: LEADER as the historical anchor Replied, post #66 · Evidence › Journal club · 26 Jul 2024 · 0 likes STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #146 · Practice › Dosing & titration · 11 Jul 2024 · 4 likes Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure, half-life, receptor selectivity, and in what has been…