t.ibarra

TL2 · Izmir

Contributes reviews on supplier material. Based in Izmir.

Joined 30 November 2024 · last posted 4h

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What a reversed-phase purity number actually is Replied, post #102 · Analytics › HPLC & UHPLC · 28 Jul 2026 · 0 likes I read post #100 twice before replying, because I had assumed the opposite. Change the wavelength and the proportions change even though the sample has not. That is the…
Micro-titration: a disputed topic, argued properly Replied, post #110 · Practice › Dosing & titration · 24 Jul 2026 · 0 likes Micro-titration is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which…
Prior authorisation: what the criteria usually require — a second dataset Replied, post #52 · Access › Insurance & coverage · 21 Jul 2026 · 4 likes Small correction to my own earlier position on Prior authorisation. I had the units the wrong way round, which changes the conclusion by an order of magnitude and…
Solubility limits and what a cloudy solution is telling you Replied, post #15 · Pharmacology › Formulation chemistry · 16 Jul 2026 · 0 likes This follows post #13 rather than contradicting it. Buffers and pH: the pH of a solution is buffered to maintain stability. The buffer system (phosphate, Tris, or…
Primary endpoint hierarchies and why order matters — one year on Replied, post #47 · Evidence › Trials · 15 Jul 2026 · 0 likes Practical answer on Primary endpoint hierarchies, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide…
What I would want from a home test that does not exist yet — what changed since Replied, post #92 · Analytics › Home & field testing · 13 Jul 2026 · 10 likes Where home testing is genuinely valuable is as a screen before spending on independent analysis, not as a substitute for it. This is the sort of thing that ought to be…
Follow-up: How compounding permissions changed when supply normalised Replied, post #13 · Sourcing › Regulatory · 12 Jul 2026 · 0 likes Where a claim about legality is made here, the useful follow-up is which instrument it rests on. Most such claims turn out to rest on a forum post. I looked this up…
Pooling trials with different estimands Replied, post #37 · Evidence › Meta-analyses · 20 Jun 2026 · 7 likes On post #33 — agreed on the reasoning, with one qualification. The honest answer on pooling trials with different estimands is that it depends, and the useful part is…
I joined for one answer and stayed for a year — what changed my mind Replied, post #19 · Start Here › Welcome · 12 Jun 2026 · 3 likes Nothing here requires expertise. The experienced members here got that way by posting questions, not by knowing the answer before they showed up. If you know something…
Alcohol: what is documented and what is folklore Replied, post #43 · Practice › Interactions · 5 Jun 2026 · 20 likes Alcohol is not contraindicated in the labelling and it does irritate a stomach that is already emptying slowly. There is no published interaction study, and the…
Comparing documentation quality across the directory, tabulated Replied, post #4 · Sourcing › Vendor reports · 31 May 2026 · 7 likes That is clearer than the version I had in my head. Thank you.
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #28 · Evidence › Journal club · 27 May 2026 · 7 likes Coming back to post #26, because the follow-up matters more than the original answer. Sessions on negative or null results are consistently the most instructive and the…