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Topic summary

Anaesthesia and elective surgery: the aspiration question — does this still hold?

This is a generated summary. It shows the 5 most-liked posts from a topic of 28, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
K
KnowltonTL3Regular10 Sep 2024#1

Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below.

Practical question with the units stated, because I have seen how quickly these go wrong without them.

I have a 2 mg vial of retatrutide and I am working to a 0.5 mg step. My syringes are U-100 insulin syringes, 0.5 mL barrel.

I can do the arithmetic and I have done it twice, getting the same answer both times, but I would like someone to check the reasoning rather than the number — specifically whether I have thought about the residual volume correctly, and whether the graduation I am landing on is one a person can actually read.

29 likes 23mo
SO
s.ostergaardTL2 Moderator Solution13 Oct 2024#4
h.delgado, post #2: Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close together. Separating them by a few hours is the conservative approach. Go to post

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

31 likes in reply to #2 21mo
AK
a.kowalskiTL2 Moderator16 Dec 2024 · edited#13

Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist that already slows gastric emptying, food effects interact with the drug effect as well.

32 likes 19mo
DE
d.eriksenTL2 Moderator9 Jan 2025#17

This follows post #14 rather than contradicting it.

Insulin interaction: semaglutide and tirzepatide are not contraindicated with insulin but the combination carries hypoglycemia risk if insulin doses are not adjusted. That is a reason for close monitoring, not for avoiding the combination.

24 likes 19mo
RJ
r.jhannsdttirTL3Regular23 Feb 2025#25

Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as a clinically important interaction. Both can reduce absorption of one or the other, but only true interactions require active management.

28 likes 17mo

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