Topic summary

Journal club: PIONEER 6 as a safety trial

Evidence › Journal club effect size journal club number needed to treat risk of bias randomised trial

This is a generated summary. It shows the 5 most-liked posts from a topic of 19, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

o.nybergTL2 Moderator6 Sep 2025#3

sourced_claims, post #1: Posting this under the heading it deserves: Journal club: PIONEER 6 as a safety trial Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it before posting; the discussion is much better when everyone has. The question I would like us to start with is what the trial set out to estimate,… Go to post

Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your population to apply the results? (4) What was the absolute effect, not just the relative one? (5) What are the two strongest criticisms available?

28 likes in reply to #1 11mo

k.kimaniTL2 Moderator30 Oct 2025 · edited#7

Makinen, post #2: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is essential because the components differ in how patient-important they are.

20 likes in reply to #2 9mo

n.ramosTL2 Moderator26 Dec 2025#12

SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower and more variable than injectable.

24 likes in reply to #1 7mo

e.almeidaTL2Member6 Jan 2026#13

On post #9 — agreed on the reasoning, with one qualification.

STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially larger than anything previously achieved pharmacologically.

11 likes 7mo

c.nybergTL2 Moderator6 Feb 2026 · edited#16

18 likes 6mo

Read the full topic (19 posts)

This topic was referenced in

Journal club: how we handle discontinuation in obesity trials — what changed sinceEvidence › Journal club · 18 replies

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Journal club: FLOW and the renal composite, component by component Evidence › Journal club randomised trial estimand risk of bias On the subject in the title: Journal club: FLOW and the renal composite, component by component Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…	+84	91	18k	2y
Journal club: STEP 8 and the fairness of the comparator dose Evidence › Journal club estimand number needed to treat journal club Journal club: STEP 8 and the fairness of the comparator dose — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 8 ( JAMA , 2022) and finding…	+2	6	39k	12mo
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Journal club: is percentage weight change the right endpoint? Evidence › Journal club number needed to treat randomised trial journal club Solved Journal club: is percentage weight change the right endpoint? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-OSA (…	+116	120	23k	3mo
Journal club: STEP 3 and the intensive behavioural therapy floor Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with STEP 4 (…	+6	10	13k	28d

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