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Devices · Pens & autoinjectors

Needle changes between doses on a reusable pen

KM
k.marchandTL222 Mar 2025#1

Posting this under the heading it deserves: Needle changes between doses on a reusable pen Everything below is what sits behind that.

The question about needle changes between doses that I actually want answered is the second one below. The first is context and I have kept it short.

Both are stated with units, and I have said what I already checked so that nobody repeats it.

23 likes 16mo
K
KLindqvistTL4 Moderator3 Apr 2025 · edited#2

No disagreement from me. Posting only so the question does not look ignored.

25 likes 16mo
KL
k.laurentTL211 Apr 2025#3

Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the first injection.

I would put a moderate confidence on that and no more.

0 likes 16mo
SK
s.karlsen_rphTL3Pharmacist18 Apr 2025#4

I read post #3 twice before replying, because I had assumed the opposite.

A pen that has been dropped may not be visibly damaged and may not deliver accurately afterwards. Manufacturers say to replace rather than to test, and there is no test a user can do.

4 likes 15mo
AW
a.weissTL224 Apr 2025#5
KR
k.roosTL21 May 2025#6

Travel with a pen raises a cold-chain question and a documentation question. The second is the one people forget until an airport.

That is all I can say without guessing.

0 likes 15mo
KS
k.salinasTL27 May 2025#7
a.weiss, post #5: A pen delivers a fixed or dialled dose from a cartridge and is a metering device rather than simply a covered syringe. That is why dose changes are constrained to whatever the mechanism supports. I would rather say I do not know than round it up to an answer. Go to post

That is clearer than the version I had in my head. Thank you.

1 like in reply to #5 15mo
DF
d.fontaineTL212 May 2025#8

Coming back to post #6, because the follow-up matters more than the original answer.

Some pens indicate remaining doses and some do not, and reading the residual volume by eye through a window is unreliable at the end of a cartridge.

7 likes 15mo
HM
h.mukherjeeTL1Member18 May 2025#9
d.fontaine, post #8: Coming back to post #6, because the follow-up matters more than the original answer. Some pens indicate remaining doses and some do not, and reading the residual volume by eye through a window is unreliable at the end of a cartridge. Go to post

Comparing cost per milligram between a pen and a vial ignores wastage, dead volume and the number of doses actually obtainable. Cost per delivered dose at your dose is the comparison that survives.

24 likes in reply to #8 14mo
MM
m.malinowskiTL224 May 2025#10
KLindqvist, post #2: No disagreement from me. Posting only so the question does not look ignored. Go to post

Worth separating two things that post #6 runs together.

Where a device exists in more than one presentation, the instructions differ in small ways between them. Reading the leaflet that came with the one in your hand is the point.

0 likes in reply to #2 14mo
CN
c.niemelTL3Regular29 May 2025#11

Nothing here is medical advice, and pen technique is the single easiest thing to have demonstrated in person rather than learned from a description.

30 likes 14mo
RM
r.mwangiTL23 Jun 2025#12

Seconded. It reads as careful rather than confident, which is the right register.

15 likes 14mo
EC
excursion_checkTL3Regular8 Jun 2025#13
r.mwangi, post #12: Seconded. It reads as careful rather than confident, which is the right register. Go to post

Worth separating two things that post #9 runs together.

Pen mechanics: most pens are dial-and-inject devices where you dial the dose on the pen and push the button to inject. Understanding your specific pen's mechanism prevents dose errors.

Someone will know this better than I do and I hope they say so.

5 likes in reply to #12 14mo
SV
s.vanheckeTL213 Jun 2025#14
m.malinowski, post #10: Worth separating two things that post #6 runs together. Where a device exists in more than one presentation, the instructions differ in small ways between them. Reading the leaflet that came with the one in your hand is the point. Go to post

Post #13 is right about the mechanism and I think understates the practical bit.

Needle changes between doses are specified for a reason and the reasons are dose accuracy and sterility rather than comfort alone.

0 likes in reply to #10 13mo
TT
taper_tableTL3Regular18 Jun 2025#15

Dose counters: pens show the remaining number of doses. When the counter reaches zero, the pen is empty and cannot deliver more. Noting the counter before injection prevents running out unexpectedly.

Second-hand, so weight it accordingly.

0 likes 13mo
PB
p.boatengTL223 Jun 2025#16

Storage instructions for a pen typically differ before and after first use, and the in-use period is the one people miss. It is on the carton.

The conclusion is tentative; the arithmetic underneath it is not.

21 likes 13mo
LC
l.chevalierTL3Regular28 Jun 2025#17
k.marchand, post #1: Posting this under the heading it deserves: Needle changes between doses on a reusable pen Everything below is what sits behind that. The question about needle changes between doses that I actually want answered is the second one below. The first is context and I have kept it short. Both are stated with units, and I have said what I… Go to post

On post #13 — agreed on the reasoning, with one qualification.

Off-label dosing with a pen: if you want to deliver a dose different from the pen's pre-set steps (e.g., halfway between two step doses), that is off-label use. Some pens allow it; others do not. Confirm before attempting.

9 likes in reply to #1 13mo
MA
m.adebayoTL22 Jul 2025#18

A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a cold syringe is. Room temperature for a short while first is the standard advice.

2 likes 13mo
SD
s.dziedzicTL27 Jul 2025#19

I read post #17 twice before replying, because I had assumed the opposite.

Disposal of a used pen is a sharps question even where the needle is retracted, and local rules vary more than people expect.

I would put the burden of proof on the interesting explanation, not the dull one.

0 likes 13mo
CA
c.adebayoTL212 Jul 2025#20

This follows post #17 rather than contradicting it.

Storage after first use: most pens can be stored at room temperature after first use, even if unrefrigerated, for a limited time (often 28 days). Check your specific pen's labelling.

A single observation, in a thread that deserves better than single observations.

28 likes 13mo
DV
d.vukovicTL216 Jul 2025#21

A pen that will not dial to the intended dose is usually telling you the cartridge does not contain enough for it. That is a designed behaviour rather than a fault.

13 likes 12mo
DB
dr_bhattacharyaTL3Physician21 Jul 2025#22

Needle installation: some pens require a fresh needle for each injection; others have a single needle that stays attached. Check the design of your pen.

26 likes 12mo
SO
s.okaforTL225 Jul 2025#23
s.karlsen_rph, post #4: I read post #3 twice before replying, because I had assumed the opposite. A pen that has been dropped may not be visibly damaged and may not deliver accurately afterwards. Manufacturers say to replace rather than to test, and there is no test a user can do. Go to post

Post #22 is right about the mechanism and I think understates the practical bit.

The instruction leaflet for a licensed pen is a genuinely good technical document and is almost never read past the first page. It answers most of what gets asked here.

I have kept the units in throughout, for the obvious reason.

0 likes in reply to #4 12mo
LG
lc_gradientTL3Analytical chemist30 Jul 2025#24

That matches what I have seen, for whatever a single anecdote is worth.

4 likes 12mo
HF
h.falkTL23 Aug 2025#25

The click count on a dialled pen is a mechanical property of that pen and is not a universal unit. Counting clicks across two different devices is not a conversion.

Written from notes rather than memory, which is why the numbers are specific.

18 likes 12mo
TD
titration_diaryTL3Regular7 Aug 2025#26

Coming back to post #25, because the follow-up matters more than the original answer.

Pen confusion between compounds: if you are using multiple pens or alternating pens, confirming you have the correct pen before injection prevents administration errors. Check the label every time.

A modest claim, modestly supported.

0 likes 12mo
TD
t.duarteTL211 Aug 2025#27
d.fontaine, post #8: Coming back to post #6, because the follow-up matters more than the original answer. Some pens indicate remaining doses and some do not, and reading the residual volume by eye through a window is unreliable at the end of a cartridge. Go to post

Post #26 answers the question as asked. The question underneath it is different.

Priming exists because the needle and the cartridge path contain air after a needle change. Skipping it means the first fraction of the dose is not liquid.

Worth one more sentence than it usually gets.

1 like in reply to #8 12mo
EF
e.ferreiraTL3Regular16 Aug 2025#28
s.vanhecke, post #14: Post #13 is right about the mechanism and I think understates the practical bit. Needle changes between doses are specified for a reason and the reasons are dose accuracy and sterility rather than comfort alone. Go to post

Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to leakage at the site. It is on the instruction leaflet and it is the step most often skipped.

The interesting part of this is the exception, and I do not understand the exception.

8 likes in reply to #14 11mo
AN
a.nwosuTL220 Aug 2025#29

This follows post #26 rather than contradicting it.

The instruction leaflet for a licensed pen is a genuinely good technical document and is almost never read past the first page. It answers most of what gets asked here.

The evidence for this is thinner than the way I have phrased it suggests.

5 likes 11mo
AB
a.batistaTL224 Aug 2025#30
KLindqvist, post #2: No disagreement from me. Posting only so the question does not look ignored. Go to post

Thank you — that answers what I came here to find out.

13 likes in reply to #2 11mo