This follows the opening post rather than contradicting it.
For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Picking up post #47: that is the part I would want checked first.
Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is extrapolating beyond the data.
On post #52 — agreed on the reasoning, with one qualification.
Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is extrapolating beyond the data.
I read post #96 twice before replying, because I had assumed the opposite.
Gastroparesis: pre-existing severe delayed gastric emptying can worsen with compounds that slow it further. Discussion with a clinician is prudent if this history exists.
On post #120 — agreed on the reasoning, with one qualification.
Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.
Read the full topic (128 posts)
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Adolescents: a distinct evidence base — one year on
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[2026 update] People with a low starting BMI: where the evidence stops
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Athletes in weight-category sports: a different risk calculus — a second dataset
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+37 | 41 | 16k | 20mo |
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Renal impairment: what the labelling says about dose
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4 | 8.9k | 19mo | |
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Type 1 diabetes: off-label use and the evidence gap
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2 | 2.3k | 1d |
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History of disordered eating and why it changes the conversation
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Gastro-oesophageal reflux: improving or worsening?
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