The figure that circulates in coverage is almost always whichever estimand gives the larger effect. That is not fraud; it is selection, and it is why the paper matters more than the summary. I have seen it go both ways, which is why I hedge.
What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked.
Statistical analysis plan, and specifically the version of it that the documentation does not cover. The maintained page handles the general case well and stops exactly where my question starts.
Setting out the gap in case it is a gap in the page rather than a gap in what is known.
That is a fair summary of where the discussion has got to.
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Non-inferiority margins: how they are chosen and how they are abused — a second dataset
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+32 | 37 | 574 | 5mo |
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+30 | 34 | 29k | 13mo |
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+49 | 53 | 643 | 19mo |
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+125 | 146 | 13k | 15mo |
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Why fasting instructions for oral semaglutide are not optional advice — does this still hold?
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+98 | 106 | 3.1k | 10mo |
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4 | 1.3k | 1mo | |
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+21 | 25 | 45k | 7mo |
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2 | 61k | 14mo |