Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below.
Appetite effects: what I expected, what I found, and the gap between them.
I am posting the gap rather than a theory about it. My theories about gaps like this one have not held up well.
I read the opening post twice before replying, because I had assumed the opposite.
GLP-1 receptor signalling: the GLP-1 receptor is expressed on beta cells (insulin secretion), on neurons (appetite and gastric motility), and on myocardium (contractility). Different tissues respond to the same signal in different ways.
I would not lead a decision with this, but I would not ignore it either.
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