20 categories

Pharmacology

Receptor biology, pharmacokinetics and formulation chemistry — the mechanistic layer under everything else.

50 topics2,108 posts5 solved Moderators: dr_okonkwo, KLindqvist About this category

Receptor biology 18 Pharmacokinetics 16 Formulation chemistry 16

50 topics · page 1 of 2

Topic	Participants	Replies	Views	Activity
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
About the Pharmacokinetics category Pharmacology › Pharmacokinetics semaglutide tirzepatide liraglutide Pinned Wiki Half-life, accumulation, steady state, albumin binding, and why weekly dosing works. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	32k	8mo
About the Formulation chemistry category Pharmacology › Formulation chemistry bacteriostatic water sterile water cloudy or discoloured solution Pinned Wiki Buffers, pH, isotonicity, preservatives, lyophilisation and excipient function. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…		4	4.5k	18mo
Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology semaglutide retatrutide tirzepatide Pinned On the subject in the title: Glucagon receptor agonism in a weight-loss compound Working notes rather than a conclusion. Glucagon receptor agonism: setting out the arithmetic in full, because I have had to do…		2	5.1k	20mo
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…	+52	57	25k	just now
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. Reading back through what has been written here about Solubility limits, three…	+38	43	29k	13h
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about GIP receptor agonism…	+10	14	15k	16h
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. The question about solubility limits that I actually want answered is the…	+11	15	34k	20h
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…	+90	98	30k	22h
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Peak-to-trough ratio,…	+57	61	708	1d
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…	+28	32	437	8d
Peak-to-trough ratio at steady state for a weekly agent Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+58	64	9.7k	2mo
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of clearance pathways is wrong? I…	+11	15	43k	2mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…	+73	78	3.5k	2mo
Coming back to: Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics missed dose semaglutide worked example Closed Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that. A narrow question about Washout, deliberately narrow, because the…	+128	139	3k	3mo
Follow-up: Lyophilisation and why the cake looks the way it does Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Lyophilisation and why the cake looks the way it does Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about Lyophilisation in a thread last spring and I would…	+10	14	11k	3mo
GLP-1 receptor distribution: central and peripheral — one year on Pharmacology › Receptor biology long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+7	11	43k	3mo
[2026 update] Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water cloudy or discoloured solution Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. A formulation question rather than a pharmacological one, though the…		2	773	3mo
Coming back to: Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example semaglutide On the subject in the title: Half-life, steady state, and accumulation worked through Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+14	18	15k	3mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the kinetics rather than the pharmacology,…	+110	126	14k	4mo
Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry cloudy or discoloured solution counter-ion content sterile water bacteriostatic water On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. I was wrong about adsorption in a thread last spring and I would like to correct it…	+13	17	4.3k	5mo
Lyophilisation and why the cake looks the way it does Pharmacology › Formulation chemistry sterile water bacteriostatic water storage cloudy or discoloured solution Posting this under the heading it deserves: Lyophilisation and why the cake looks the way it does Everything below is what sits behind that. I was wrong about lyophilisation in a thread last spring and I…	+33	37	60k	6mo
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Pharmacology › Receptor biology retatrutide amylin analogues semaglutide Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. A narrow question about…	+57	63	1k	6mo
Follow-up: Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Glucagon receptor agonism that I did not know…	+5	9	21k	7mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A follow-up question about appetite effects that I did not know to ask the first time. The earlier thread…	+86	90	61k	9mo
Amylin receptor signalling and satiety Pharmacology › Receptor biology tirzepatide semaglutide amylin analogues Wiki Amylin receptor signalling and satiety Writing it up because I had to work it out twice and would rather nobody else did. Asking about amylin receptor signalling and satiety directly, because I have read four…	+22	26	1.8k	9mo
Follow-up: Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics semaglutide liraglutide worked example Subcutaneous absorption kinetics and site differences — setting out what I have, and where I think it stops being reliable. A follow-up question about Subcutaneous absorption kinetics and site that I did not…		4	9.9k	10mo
Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics semaglutide missed dose worked example Closed Washout: how long is long enough, and for what purpose — setting out what I have, and where I think it stops being reliable. A narrow question about washout, deliberately narrow, because the broad version has…	+63	70	13k	10mo

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