Tags · Status

long read

Substantial and worth the time.

42 topics 6 solved Group: Status

Related in this group: solved · open question · needs a source · beginner friendly · worked example · data table · disputed

42 topics · page 1 of 2

Topic	Participants	Replies	Views	Activity
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+52	57	25k	just now
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if…	+102	121	21k	1h
What other technical communities get right that we do not Lounge › Off topic beginner friendly long read Wiki What other technical communities get right that we do not — that is the question, and I have not found it answered plainly anywhere I have looked. Lower-stakes topic, but the sourcing rule still applies if…	+2	6	23k	5h
A 40-week log with the measurement method stated — what changed since Outcomes › Progress reports effect size data table DXA long read Solved A 40-week log with the measurement method stated — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a…	+9	13	2.1k	9h
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost…	+109	125	42k	10h
Comparing my trajectory with the trial curves, carefully — a second dataset Outcomes › Progress reports effect size data table long read Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that…	+77	81	16k	11h
Follow-up: The most useful thing you learned here that was not the answer you came for Lounge › Off topic beginner friendly long read On the subject in the title: The most useful thing you learned here that was not the answer you came for Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if…	+30	34	9.7k	11h
An 18-month record including the parts that went badly Outcomes › Progress reports data table long read effect size DXA An 18-month record including the parts that went badly — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a method is…	+77	81	17k	12h
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic…	+10	14	15k	16h
Spreadsheets: an appreciation — what changed since Lounge › Off topic long read beginner friendly Spreadsheets: an appreciation — what changed since — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+102	113	26k	17h
[2026 update] Waist circumference technique and its repeatability Outcomes › Progress reports DXA long read effect size data table Posting this under the heading it deserves: Waist circumference technique and its repeatability Everything below is what sits behind that. Longitudinal report with the method stated, because a number without…	+23	27	5.9k	21h
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+90	98	30k	22h
The most useful thing you learned here that was not the answer you came for Lounge › Off topic long read beginner friendly The most useful thing you learned here that was not the answer you came for Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still…	+54	61	57k	1d
A plateau that disappeared when I changed how I measured — the long version Outcomes › Progress reports effect size data table long read A plateau that disappeared when I changed how I measured — the long version — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number…	+49	54	9.4k	1mo
Books and papers worth reading that are not about this at all — one year on Lounge › Off topic long read beginner friendly Books and papers worth reading that are not about this at all — one year on — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if…	+3	7	424	1mo
The best-written scientific paper you have read Lounge › Off topic long read beginner friendly The best-written scientific paper you have read Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…	+69	74	1.1k	2mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+73	78	3.5k	2mo
GLP-1 receptor distribution: central and peripheral — one year on Pharmacology › Receptor biology long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+7	11	43k	3mo
A plateau that disappeared when I changed how I measured Outcomes › Progress reports DXA long read effect size Posting this under the heading it deserves: A plateau that disappeared when I changed how I measured Everything below is what sits behind that. Longitudinal report with the method stated, because a number…	+27	31	7.2k	3mo
Waist circumference technique and its repeatability Outcomes › Progress reports data table long read effect size DXA Waist circumference technique and its repeatability — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes…	+55	60	11k	5mo
What I would record differently if I started again Outcomes › Progress reports DXA long read data table effect size Closed Asking directly, because I could not find a straight answer: What I would record differently if I started again Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…		2	12k	5mo
Seven-day rolling means and why weekly readings mislead — one year on Outcomes › Progress reports DXA data table long read Solved On the subject in the title: Seven-day rolling means and why weekly readings mislead — one year on Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without…	+78	88	16k	5mo
Follow-up: Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+5	9	21k	7mo
Comparing my trajectory with the trial curves, carefully Outcomes › Progress reports DXA effect size long read data table Solved Posting this under the heading it deserves: Comparing my trajectory with the trial curves, carefully Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+86	92	54k	7mo
[2026 update] Reporting a disappointing outcome, and why it belongs here Outcomes › Progress reports DXA long read data table Pinned Closed On the subject in the title: Reporting a disappointing outcome, and why it belongs here Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is…		2	11k	8mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+61	66	15k	8mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A documentation question rather than an analytical one. I have a certificate in front of me that reports a…	+86	90	61k	9mo
A 40-week log with the measurement method stated Outcomes › Progress reports DXA long read data table On the subject in the title: A 40-week log with the measurement method stated Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not a…	+87	97	18k	9mo
The most useful thing you learned here that was not the answer you came for — a second dataset Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: The most useful thing you learned here that was not the answer you came for — a second dataset Everything below is what sits behind that. Lower-stakes topic, but…	+111	121	6.6k	9mo
GIP receptor agonism and the argument about direction Pharmacology › Receptor biology tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise…		2	867	10mo

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