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Intersection · Pharmacology × long read

Pharmacology topics tagged long read

Topics in Pharmacology carrying the tag long read. Substantial and worth the time.

14 topics

Topic	Participants	Replies	Views	Activity
Receptor desensitisation as a tolerance hypothesis, and its weak evidence tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…	+52	57	25k	just now
GIP receptor agonism and the argument about direction — does this still hold? long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about GIP receptor agonism…	+10	14	15k	16h
GLP-1 receptor distribution: central and peripheral semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…	+90	98	30k	22h
Amylin receptor signalling and satiety — what changed since tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…	+73	78	3.5k	2mo
GLP-1 receptor distribution: central and peripheral — one year on long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+7	11	43k	3mo
Follow-up: Glucagon receptor agonism in a weight-loss compound amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Glucagon receptor agonism that I did not know…	+5	9	21k	7mo
Revisiting: GLP-1 receptor distribution: central and peripheral amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo
Follow-up: Why appetite effects are mostly central tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A follow-up question about appetite effects that I did not know to ask the first time. The earlier thread…	+86	90	61k	9mo
GIP receptor agonism and the argument about direction tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. A question about GIP receptor agonism that I think has a definite answer, unlike…		2	867	10mo
Vagal afferents and the gut-brain pathway — one year on amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about Vagal afferents rather than a disguised…		2	136	11mo
Vagal afferents and the gut-brain pathway semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am…	+5	9	44k	13mo
Why appetite effects are mostly central amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Appetite effects: what I expected, what I found, and the gap between them. I…		2	56k	16mo
Biased agonism: a real phenomenon, an over-used explanation semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. Trying to work out what would count as evidence on biased…	+130	135	23k	16mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Biased agonism is…	+49	56	47k	17mo

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