Tags · Technique

stability-indicating method

A method that can separate the compound from its degradation products.

20 topics 8 solved Group: Technique

20 topics

Topic	Participants	Replies	Views	Activity
Revisiting: Spike-and-recover accuracy for a peptide assay Analytics › Method validation LOD & LOQ system suitability stability-indicating method linearity Revisiting: Spike-and-recover accuracy for a peptide assay — setting out what I have, and where I think it stops being reliable. I was wrong about Spike-and-recover accuracy in a thread last spring and I…		2	6.8k	21h
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Collecting what is known about forced degradation studies…	+100	106	35k	2d
Validating a method you did not develop Analytics › Method validation precision & repeatability recovery linearity stability-indicating method On the subject in the title: Validating a method you did not develop Working notes rather than a conclusion. What changes if the standard account of validating a method is wrong? I ask because I have been…	+10	14	15k	3mo
Sample handling between despatch and injection Analytics › Method validation stability-indicating method LOD & LOQ linearity precision & repeatability Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on sample handling between…	+63	68	2.4k	3mo
Spike-and-recover accuracy for a peptide assay Analytics › Method validation linearity system suitability stability-indicating method LOD & LOQ Wiki Posting this under the heading it deserves: Spike-and-recover accuracy for a peptide assay Everything below is what sits behind that. Asking about spike-and-recover accuracy on behalf of the question I keep…	+121	126	1.5k	4mo
About the Method validation category Analytics › Method validation stability-indicating method linearity LOD & LOQ Pinned Wiki Specificity, linearity, precision, accuracy, robustness, system suitability, and why two labs disagree. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	468	5mo
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Posting the method first, because I know what the first three…	+10	14	13k	5mo
Revisiting: Sample handling between despatch and injection Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Revisiting: Sample handling between despatch and injection Everything below is what sits behind that. Reading back through what has been written here about Sample…	+5	9	1.1k	6mo
Why one laboratory's 98.4% and another's 96.1% may not contradict Analytics › Method validation stability-indicating method LOD & LOQ linearity Solved Wiki Why one laboratory's 98.4% and another's 96.1% may not contradict I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the…	+28	37	457	7mo
An inter-laboratory comparison on one lot, tabulated — what changed since Analytics › Method validation stability-indicating method LOD & LOQ system suitability precision & repeatability An inter-laboratory comparison on one lot, tabulated — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of inter-laboratory…	+24	28	3.3k	7mo
Robustness: the parameters worth deliberately varying Analytics › Method validation stability-indicating method linearity precision & repeatability Robustness: the parameters worth deliberately varying Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about robustness, deliberately narrow, because the…	+53	57	664	8mo
LOD and LOQ: definitions people get wrong Analytics › Method validation precision & repeatability recovery stability-indicating method linearity Closed LOD and LOQ: definitions people get wrong — setting out what I have, and where I think it stops being reliable. What changes if the standard account of LOD and LOQ is wrong? I ask because I have been treating…		2	43k	8mo
Forced degradation studies: designing one that is informative — does this still hold? Analytics › Method validation stability-indicating method precision & repeatability LOD & LOQ system suitability Solved The question in the title: Forced degradation studies: designing one that is informative — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Forced…	+37	41	1.2k	12mo
Repeatability versus intermediate precision Analytics › Method validation precision & repeatability recovery LOD & LOQ linearity Solved Repeatability versus intermediate precision — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on repeatability versus intermediate precision.…	+119	134	34k	13mo
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. What changes if the standard account of relative retention time is wrong? I…	+7	11	28k	14mo
When to suspect the method rather than the sample Analytics › Method validation recovery stability-indicating method linearity system suitability Solved When to suspect the method rather than the sample — that is the question, and I have not found it answered plainly anywhere I have looked. Two reports on the same lot, and I would like help deciding whether…	+109	115	63k	15mo
Validating a method you did not develop — does this still hold? Analytics › Method validation stability-indicating method LOD & LOQ precision & repeatability recovery Solved Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Validating a method, and specifically the version of…	+128	148	47k	16mo
What a stability-indicating method is and how you demonstrate one — one year on Analytics › Method validation precision & repeatability system suitability stability-indicating method recovery Solved What a stability-indicating method is and how you demonstrate one — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about stability-indicating…	+100	112	15k	19mo
Coming back to: When to suspect the method rather than the sample Analytics › Method validation precision & repeatability LOD & LOQ linearity recovery Solved Wiki When to suspect the method rather than the sample I have a specific reason for asking rather than idle curiosity, and the context is below. Two reports on the same lot, and I would like help deciding whether…	+116	135	42k	19mo
Relative retention time as a better inter-laboratory comparator — does this still hold? Analytics › Method validation LOD & LOQ precision & repeatability stability-indicating method recovery Solved Wiki Relative retention time as a better inter-laboratory comparator — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard…	+11	15	21k	21mo

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