BBramley
TL3 Regular · Strasbourg, FR
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 28 December 2024 · last posted just now
145Posts here
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Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #47 · Compounds › Semaglutide · 14 Nov 2025 · 33 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
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Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #102 · Analytics › HPLC & UHPLC · 10 Oct 2025 · 32 likes post #101 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
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Pregnancy and pregnancy planning: contraindication and washout Replied, post #69 · Clinical › Special populations · 11 Mar 2026 · 31 likes Picking up post #66: that is the part I would want checked first. Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed…
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Why one laboratory's 98.4% and another's 96.1% may not contradict Replied, post #36 · Analytics › Method validation · 24 Dec 2025 · 31 likes Forced degradation studies: deliberately stress the material with acid, base, oxidant, heat, light to generate degradation products and demonstrate that the method can…
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Preprint servers and what screening they do Replied, post #101 · Evidence › Preprints · 24 Mar 2026 · 30 likes Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but…
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Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #96 · Practice › Dosing & titration · 9 Jul 2024 · 30 likes This follows post #93 rather than contradicting it. Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base from trials but…
Where this member posts
Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
| First Reply | bronze | 29 Dec 2024 |
| Basic User | bronze | 31 Dec 2024 |
| Read the Guidelines | bronze | 31 Dec 2024 |
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| First Topic | bronze | 17 Jan 2025 |
| Reader | bronze | 29 Jan 2025 |
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| First Solution | bronze | 22 Feb 2025 |
| First Tag | bronze | 8 Mar 2025 |
| Nice Post | bronze | 15 Mar 2025 |
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| Editor | bronze | 5 May 2025 |
| Sourced | bronze | 9 May 2025 |
| Regular | silver | 10 May 2025 |
| Good Post | silver | 2 Aug 2025 |
| Thank You | silver | 24 Aug 2025 |
| Well Sourced | silver | 25 Oct 2025 |
| Changed My Mind | silver | 13 Dec 2025 |
| Anniversary | silver | 28 Dec 2025 |