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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 2 of 40

Topic	Participants	Replies	Views	Activity
Prior authorisation: what the criteria usually require — a second dataset Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Prior authorisation: what the criteria usually require — a second dataset Everything below is what sits behind that. Posting a small dataset on Prior authorisation.…	+67	74	19k	21h
[2026 update] Documenting an adverse event properly Safety › Adverse events pancreatitis vomiting gallbladder Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about Documenting an adverse event on behalf of the question I keep seeing asked…	+18	22	4.3k	1d
Cleaning a self-reported dataset and what you throw away — what changed since Data & Tools › Datasets observational data site feedback data table confounding Solved Posting this under the heading it deserves: Cleaning a self-reported dataset and what you throw away — what changed since Everything below is what sits behind that. What changes if the standard account of…		2	2k	1h
How much context is too much context in a first post? Start Here › How to Ask guidelines beginner friendly onboarding site feedback Solved How much context is too much context in a first post? I have a specific reason for asking rather than idle curiosity, and the context is below. Counting it rather than describing it, because the count is the…	+69	74	935	18d
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. A comparison question rather than a question about one…	+83	91	46k	1d
Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis ipamorelin observational data GHRP class tesamorelin Solved Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin evidence quality…		2	25k	9d
What to bring: records that a clinician can actually use — a second dataset Clinical › Prescriber conversations telehealth beginner friendly prior authorisation What to bring: records that a clinician can actually use — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how to describe something…	+80	86	5.6k	3h
Deletion sequences: expected mass shifts by residue — the long version Analytics › Impurities & related substances water content endotoxin testing data table forced degradation On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Deletion sequences keeps being re-asked here and I think that is…	+21	25	6.9k	10h
Common supplements people ask about, assessed one at a time Practice › Interactions insulin needs a source hypoglycaemia metformin Common supplements people ask about, assessed one at a time — setting out what I have, and where I think it stops being reliable. A follow-up question about common supplements that I did not know to ask the…	+101	107	28k	12h
Coming back to: Batch date after test date, and other internal inconsistencies Analytics › COA interpretation reference standards amino acid analysis documentation quality certificate of analysis On the subject in the title: Batch date after test date, and other internal inconsistencies Working notes rather than a conclusion. Batch date — I have the observation and I do not trust my interpretation of…	+21	27	420	3h
[2026 update] Antibiotics and a course of something with delayed emptying Practice › Interactions metformin needs a source delayed gastric emptying insulin On the subject in the title: Antibiotics and a course of something with delayed emptying Working notes rather than a conclusion. Something changed and I would like to know whether it should have. Same…	+88	97	19k	13h
Reading order for a first week here, and what to skip until later — what changed since Start Here › Welcome onboarding guidelines beginner friendly trust levels Reading order for a first week here, and what to skip until later — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account…	+88	93	28k	4h
BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? Compounds › Repair & healing peptides observational data needs a source BPC-157 TB-500 Solved The question in the title: BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? I will give what I have already checked below so nobody repeats it. I would like to…	+6	10	3.1k	1d
Coming back to: Telehealth prescribing models in the US Regional › North America telehealth FDA compounding insurance Posting this under the heading it deserves: Telehealth prescribing models in the US Everything below is what sits behind that. Telehealth prescribing models — I have the observation and I do not trust my…	+26	30	17k	17h
Immortal time bias in a claims-database study — one year on Evidence › Study critique effect size risk of bias confounding Solved Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. I would like to disagree carefully with the settled view on…	+41	46	3.7k	22h
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC HPLC system suitability gradient method Detection wavelength and why 214 nm and 280 nm disagree — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on Detection wavelength,…	+69	76	920	6h
Journal club: SUSTAIN 6 and its retinopathy signal Evidence › Journal club estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…	+110	122	46k	1d
How shortages have affected compounding permissions Access › Shortages shortage compounding FDA formulary How shortages have affected compounding permissions I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what people here actually do about shortages,…	+61	71	3.6k	2d
Selection into a registry and what it does to the estimate — a second dataset Evidence › Study critique confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Posting a small dataset on Selection. It is…	+28	32	1.3k	1d
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint Solved Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about…	+50	55	7.8k	2d
Journal club: STEP 1 and the treatment-policy estimand Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: STEP 1 and the treatment-policy estimand Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…		3	11k	9h
Coming back to: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration dose reduction semaglutide titration tirzepatide Solved Posting this under the heading it deserves: Where the four-week escalation interval comes from, and what it is not Everything below is what sits behind that. Four-week escalation interval — I have the…	+44	48	11k	1d
Restarting after a long gap: what the labelling implies Practice › Dosing & titration dose reduction semaglutide titration missed dose Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+41	46	11k	15h
What a reversed-phase purity number actually is Analytics › HPLC & UHPLC HPLC system suitability data table peak integration Solved The question in the title: What a reversed-phase purity number actually is I will give what I have already checked below so nobody repeats it. I would like to understand what this number means before I repeat…	+87	101	27k	4h
Second pass at: Orforglipron as a non-peptide: what changes when the molecule is small Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Second pass at: Orforglipron as a non-peptide: what changes when the molecule is small Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on…		2	17k	6h
Why I now write the concentration on the vial in marker Practice › Reconstitution syringe units bacteriostatic water concentration maths Asking directly, because I could not find a straight answer: Why I now write the concentration on the vial in marker Writing this out with the numbers in it, because "roughly" is how these go wrong. Vial: 15…	+1	5	30k	11d
What a regulator's shortage notice actually authorises Sourcing › Regulatory personal import research use only EMA FDA Solved What a regulator's shortage notice actually authorises — that is the question, and I have not found it answered plainly anywhere I have looked. Asking what a regulator's document actually says, since the…	+8	12	15k	17h
Sleep quality changes during weight loss Wellbeing › Sleep heart rate obstructive sleep apnoea fatigue On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. Asking about sleep quality changes during weight on behalf of the question I keep seeing asked…	+27	31	555	5h
Athletes in weight-category sports: a different risk calculus Clinical › Special populations older adults adolescents disordered eating chronic kidney disease Solved Athletes in weight-category sports: a different risk calculus — setting out what I have, and where I think it stops being reliable. Something about athletes in weight-category sports does not reconcile and I…	+38	42	6.6k	1d
Revisiting: Protein density versus volume when you cannot eat much Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Revisiting: Protein density versus volume when you cannot eat much Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin Protein density…	+97	108	3.6k	2d