Newest first

New topics page 4

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 4 of 40

Topic	Participants	Replies	Views	Activity
Racemisation and why it is invisible to a mass measurement Analytics › Impurities & related substances counter-ion content endotoxin testing HPLC Closed Posting this under the heading it deserves: Racemisation and why it is invisible to a mass measurement Everything below is what sits behind that. A question about racemisation that I think has a definite…	+120	127	41k	1mo
Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis blood pressure Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Heart failure with preserved ejection keeps being re-asked here and I…	+19	23	311	12d
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Compounds › Retatrutide retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. I would like to disagree…	+43	47	19k	2d
Sulphur-smelling eructation: mechanism and what helps Practice › Side effects vomiting delayed gastric emptying nausea Sulphur-smelling eructation: mechanism and what helps — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on sulphur-smelling…		2	58	1d
Why a pen's dose steps are fixed and what that costs you Devices › Pens & autoinjectors dead volume storage subcutaneous injection missed dose Solved The question in the title: Why a pen's dose steps are fixed and what that costs you I will give what I have already checked below so nobody repeats it. A question about a device rather than about a compound,…		4	2.5k	23h
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
What a simple presence test is genuinely useful for Analytics › Home & field testing documentation quality ELISA third-party testing LOD & LOQ Solved What a simple presence test is genuinely useful for — that is the question, and I have not found it answered plainly anywhere I have looked. Trying to work out what would count as evidence on simple presence…		2	58	1d
Micronutrient adequacy at low total intake Nutrition & Training › Protein & intake constipation fatigue lean mass loss Under review Micronutrient adequacy at low total intake — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on micronutrient adequacy, before collecting…	+93	99	5.8k	1mo
Language barriers in accessing a prescription abroad Access › International personal import telehealth EMA Solved Language barriers in accessing a prescription abroad Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about language barriers in accessing in a thread last spring…		2	22k	1h
Tracking a shortage from primary sources rather than rumour — the long version Access › Shortages compounding formulary FDA Solved On the subject in the title: Tracking a shortage from primary sources rather than rumour — the long version Working notes rather than a conclusion. Tracking a shortage keeps being re-asked here and I think…		2	60	1d
[2026 update] Travelling with an injectable: documentation and practicalities Access › International telehealth EMA MHRA NHS Travelling with an injectable: documentation and practicalities Writing it up because I had to work it out twice and would rather nobody else did. Dated regional question, February 2026, because everything in…	+107	111	12k	1d
Sulfonylureas: the interaction most worth taking seriously — what changed since Practice › Interactions metformin delayed gastric emptying hypoglycaemia insulin On the subject in the title: Sulfonylureas: the interaction most worth taking seriously — what changed since Working notes rather than a conclusion. What changes if the standard account of Sulfonylureas is…	+3	7	35k	1d
Asking a follow-up: new topic or new reply? Start Here › How to Ask worked example onboarding beginner friendly Solved Asking a follow-up: new topic or new reply? — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about asking a follow-up in one place, because it…	+68	73	40k	1d
[2026 update] Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Medutest VendorInvestigate blind sampling third-party testing Solved On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+121	128	51k	17h
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. Submitting a sample keeps being re-asked here and I think that is because the answer is…	+99	114	29k	21h
A certificate whose chromatogram axes do not match its stated method — one year on Sourcing › Red flags mislabelling moderation documentation quality Solved A certificate whose chromatogram axes do not match its stated method — one year on Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on certificate…	+103	111	8.1k	2mo
Coming back to: Payment method and the leverage it gives you, ranked Sourcing › Payments payments documentation quality research use only Payment method and the leverage it gives you, ranked — setting out what I have, and where I think it stops being reliable. A payments question, with the mechanics separated from the money. What I would like…	+21	26	43k	2d
Compounds this community declines to help with, and why — does this still hold? Compounds › Other compounds custom synthesis research use only mislabelling Compounds this community declines to help with, and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in the first post,…	+3	7	26k	7h
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation maintainership wiki post Asking directly, because I could not find a straight answer: Pages past their review date, listed — does this still hold? I have spent a fortnight trying to pin Pages past down and I want to set out where I…	+49	56	39k	11d
[2026 update] Second opinions: how to seek one without burning the first Clinical › Prescriber conversations prior authorisation beginner friendly type 2 diabetes Solved On the subject in the title: Second opinions: how to seek one without burning the first Working notes rather than a conclusion. Two things I would like separated before anyone answers on Second opinions,…		2	5.9k	1d
Insurance and replacement policies, compared Sourcing › Logistics temperature excursion cold chain customs shipping Solved On the subject in the title: Insurance and replacement policies, compared Working notes rather than a conclusion. I have spent a fortnight trying to pin insurance and replacement policies down and I want to…	+115	122	17k	17h
Carryover and the ghost peak from last week's standard — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC UV & DAD detection Solved Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Carryover…	+98	114	37k	22d
SURPASS-2 and the comparator dose question that will not go away — what changed since Compounds › Tirzepatide SURMOUNT programme tirzepatide effect size Posting this under the heading it deserves: SURPASS-2 and the comparator dose question that will not go away — what changed since Everything below is what sits behind that. What changes if the standard…	+2	6	5.5k	7h
Injecting into an area that has become firm: why not to Practice › Administration subcutaneous injection injection site rotation injection site reaction aseptic technique Solved Injecting into an area that has become firm: why not to Writing it up because I had to work it out twice and would rather nobody else did. Asking about the failure mode rather than the procedure, because the…	+82	92	26k	1mo
A reconstituted vial's beyond-use date and the reasoning behind common figures Practice › Storage & stability temperature excursion storage freeze-thaw Posting this under the heading it deserves: A reconstituted vial's beyond-use date and the reasoning behind common figures Everything below is what sits behind that. I have read the maintained page on this…	+125	129	45k	2mo
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Asking about pooling trials with different estimands on behalf of the question I keep seeing asked…	+120	132	2.3k	1d
A structured critique template this community uses — a second dataset Evidence › Study critique observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Posting a small dataset on structured critique template. It is mine,…	+47	51	16k	15h
Follow-up: The most useful thing you learned here that was not the answer you came for Lounge › Off topic beginner friendly long read On the subject in the title: The most useful thing you learned here that was not the answer you came for Working notes rather than a conclusion. A digression I have been saving for the right category. It is…	+30	34	9.7k	11h
Revisiting: Taste changes and food aversion, reported and discussed Practice › Side effects nausea vomiting constipation Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+20	25	4.3k	1d
[2026 update] Temperature indicator cards: worth asking for? Sourcing › Logistics shipping packaging customs temperature excursion Temperature indicator cards: worth asking for? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about Temperature indicator cards on behalf of the question I…	+21	26	4.5k	1d