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1,535 topics · page 39 of 40

Topic	Participants	Replies	Views	Activity
Coverage for the indication versus for the drug — a second dataset Access › Insurance & coverage prior authorisation appeals formulary insurance Solved Closed On the subject in the title: Coverage for the indication versus for the drug — a second dataset Working notes rather than a conclusion. Posting a small dataset on Coverage. It is mine, it is uncontrolled, and…	+46	50	41k	16mo
Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind it Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial Wiki On the subject in the title: Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind it Working notes rather than a conclusion. A comparison question rather than a question about one…	+2	6	2.4k	7mo
Revisiting: Why I ask for the gradient before I discuss the number Analytics › HPLC & UHPLC UV & DAD detection data table peak integration system suitability Posting this under the heading it deserves: Revisiting: Why I ask for the gradient before I discuss the number Everything below is what sits behind that. I would like to understand what this number means…	+15	19	43k	10mo
Progressive overload when the scale is falling Nutrition & Training › Resistance training fatigue DXA lean mass loss Posting this under the heading it deserves: Progressive overload when the scale is falling Everything below is what sits behind that. Trying to establish the boundary conditions on progressive overload. The…	+4	8	14k	8mo
[2026 update] Cardiovascular risk: reading the outcome trials as a set Clinical › Comorbidities PCOS type 2 diabetes chronic kidney disease blood pressure Posting this under the heading it deserves: Cardiovascular risk: reading the outcome trials as a set Everything below is what sits behind that. I have spent a fortnight trying to pin Cardiovascular risk down…	+99	103	32k	11mo
Enforcement priorities versus written rules Sourcing › Regulatory FDA personal import MHRA Enforcement priorities versus written rules — setting out what I have, and where I think it stops being reliable. Asking what a regulator's document actually says, since the summaries of it disagree. I have…		2	62k	15mo
Coming back to: What published stability data actually covers, and what it does not Practice › Storage & stability cold chain freeze-thaw storage beyond-use date Solved Closed The question in the title: What published stability data actually covers, and what it does not I will give what I have already checked below so nobody repeats it. Reading back through what has been written…	+136	148	20k	10mo
Revisiting: German, French and Dutch differences, compared Regional › European Union personal import formulary EMA cost per milligram Posting this under the heading it deserves: Revisiting: German, French and Dutch differences, compared Everything below is what sits behind that. I have spent a fortnight trying to pin German down and I want…	+90	99	32k	9mo
Domestic fridge temperature mapping: a cheap experiment Devices › Cold chain cold chain temperature excursion storage freeze-thaw Domestic fridge temperature mapping: a cheap experiment Writing it up because I had to work it out twice and would rather nobody else did. Collecting what is known about domestic fridge temperature mapping in…		2	182	14mo
Charge states for a 4 kDa peptide, worked through Analytics › Mass spectrometry high-resolution MS counter-ion content charge states LC-MS Solved On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+124	146	15k	16mo
Residual solvents and scavengers: what is looked for Analytics › Impurities & related substances counter-ion content HPLC data table forced degradation Solved On the subject in the title: Residual solvents and scavengers: what is looked for Working notes rather than a conclusion. I would like to know what people here actually do about residual solvents and…	+19	23	39k	14mo
Pharmaceutical compounding rules, summarised from primary sources Sourcing › Regulatory MHRA EMA research use only Closed Pharmaceutical compounding rules, summarised from primary sources — setting out what I have, and where I think it stops being reliable. Asking what a regulator's document actually says, since the summaries of…	+135	163	46k	17mo
An emergency department visit, described afterwards Safety › Adverse events gallbladder hypoglycaemia pancreatitis An emergency department visit, described afterwards Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on emergency…	+56	62	1.4k	11mo
Revisiting: Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides observational data needs a source TB-500 BPC-157 Solved On the subject in the title: Revisiting: Oral versus injected administration claims for BPC-157 Working notes rather than a conclusion. A follow-up question about Oral versus injected administration claims…	+23	27	7.7k	15mo
Storing a pen in use versus a pen unopened Devices › Pens & autoinjectors storage missed dose dead volume Storing a pen in use versus a pen unopened Writing it up because I had to work it out twice and would rather nobody else did. Proposing that storing a pen deserves a maintained page rather than a recurring…	+14	18	13k	14mo
About the Cold chain category Devices › Cold chain cold chain temperature excursion storage Pinned Wiki Domestic refrigeration, travel, temperature logging, and assessing an excursion after the fact. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	2k	17mo
When a tidy document is a signal and when it is decoration Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers amino acid analysis When a tidy document is a signal and when it is decoration I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of tidy document is…	+6	10	20k	10mo
Why appetite effects are mostly central Pharmacology › Receptor biology amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Appetite effects: what I expected, what I found, and the gap between them. I…		2	56k	16mo
Why oral semaglutide needs an absorption enhancer at all — what changed since Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Solved Asking directly, because I could not find a straight answer: Why oral semaglutide needs an absorption enhancer at all — what changed since What changes if the standard account of oral semaglutide is wrong? I…		2	61k	14mo
Why fasting instructions for oral semaglutide are not optional advice — does this still hold? Compounds › Oral incretins orforglipron SOUL trial PIONEER programme randomised trial Solved Asking directly, because I could not find a straight answer: Why fasting instructions for oral semaglutide are not optional advice — does this still hold? A methods question rather than a substantive one,…	+98	106	3.1k	10mo
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. Trying to work out what would count as evidence on biased…	+130	135	23k	16mo
Reading a supplier's product description as a marketing document Compounds › Other compounds custom synthesis needs a source mislabelling On the subject in the title: Reading a supplier's product description as a marketing document Working notes rather than a conclusion. Documentation question rather than a pharmacological one, but about this…	+86	97	62k	8mo
Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions metformin needs a source hypoglycaemia Solved Wiki On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter Working notes rather than a conclusion. A follow-up question about delayed gastric emptying and oral…	+110	116	43k	14mo
About the Red flags category Sourcing › Red flags mislabelling underdosing documentation quality Pinned Wiki Closed Patterns that reliably precede a problem. Documented, dated, and free of accusation without evidence. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	57k	17mo
Follow-up: Open-label extensions: what survives and what does not Evidence › Trials open label intention to treat surrogate endpoints estimand Solved Open-label extensions: what survives and what does not — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin Open-label extensions down and I want to set…	+22	26	397	16mo
Electrolyte supplements: which ones do anything — a second dataset Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure Electrolyte supplements: which ones do anything — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Electrolyte supplements. It is…		2	59k	15mo
Deamidation and the close-eluting pair it produces Analytics › Impurities & related substances forced degradation HPLC water content data table Deamidation and the close-eluting pair it produces Writing it up because I had to work it out twice and would rather nobody else did. Something about deamidation does not reconcile and I would like a second…	+33	37	46k	15mo
About the Meta-analyses category Evidence › Meta-analyses meta-analysis heterogeneity publication bias Pinned Wiki Pooled estimates, heterogeneity, publication bias, and when pooling was a mistake. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	15k	13mo
Lateral-flow and colorimetric approaches: the specificity problem Analytics › Home & field testing LOD & LOQ documentation quality ELISA Lateral-flow and colorimetric approaches: the specificity problem — setting out what I have, and where I think it stops being reliable. Lateral-flow and colorimetric approaches, and specifically the version…		2	4k	9mo
Request declined, with reasoning Meta › Feature requests site feedback translation wiki post Wiki Request declined, with reasoning — setting out what I have, and where I think it stops being reliable. I would like to know what people here actually do about request declined, as distinct from what is…	+2	6	173	13mo