This follows post #2 rather than contradicting it.
Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.
Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.
On post #13 — agreed on the reasoning, with one qualification.
Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use significant figures appropriate to your input precision.
I disagree with the reply above, and I think the disagreement is substantive rather than terminological.
The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.
post #31 is right about the mechanism and I think understates the practical bit.
Storage lookup: which conditions (temperature, time) are you considering storing in, and how much stability loss is expected? The calculator gives a rough estimate based on typical stability data. Not a substitute for your compound's specific stability data.
Read the full topic (37 posts)
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Second pass at: The storage lookup and where its data comes from
On the subject in the title: Second pass at: The storage lookup and where its data comes from Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…
|
+38 | 42 | 13k | 19d |
|
Revisiting: Bug report: the reconstitution calculator and a rounding edge case
Revisiting: Bug report: the reconstitution calculator and a rounding edge case — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…
|
+109 | 122 | 5.8k | 17mo |
|
Coming back to: Feature request: should a dose-equivalence tool exist at all?
Feature request: should a dose-equivalence tool exist at all? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…
|
+37 | 41 | 725 | 7mo |
|
The storage lookup and where its data comes from
The storage lookup and where its data comes from — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in front of…
|
+4 | 8 | 4.1k | 11mo |
|
Second pass at: The mass-error checker and its intended scope
Posting this under the heading it deserves: Second pass at: The mass-error checker and its intended scope Everything below is what sits behind that. Working through the identity arithmetic and I would like it…
|
+70 | 74 | 1.7k | 8mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Request: a diff view for wiki revisions — the long version
Posting this under the heading it deserves: Request: a diff view for wiki revisions — the long version Everything below is what sits behind that. Process question about how this site works. I have read the…
|
+96 | 104 | 61k | 6mo |
|
Measurement error in home scales, with a worked standard deviation
Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…
|
+26 | 31 | 4.3k | 4mo |
|
Revisiting: The arithmetic of an intermediate dose between two label steps
Revisiting: The arithmetic of an intermediate dose between two label steps Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…
|
+41 | 45 | 808 | 2mo |
|
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version
On the subject in the title: A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…
|
+160 | 165 | 1.9k | 12mo |
|
Gauge and length selection for subcutaneous injection
Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…
|
+50 | 55 | 1.3k | 8mo |