The Peptide CommonsEst. May 2024
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Data & Tools · Calculators · continued

The mass-error checker and its intended scope posts 121–150

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

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NicolaidesTL3Regular13 Jul 2024 · edited#121
f.novak, post #72: I read post #70 twice before replying, because I had assumed the opposite. The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience. Go to post

Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.

2 likes in reply to #72 2y
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f.piresTL2 Moderator14 Jul 2024#122

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

9 likes 2y
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aliquot_lineTL3Regular14 Jul 2024#123

post #122 is right about the mechanism and I think understates the practical bit.

Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain body mass is not a prescription.

29 likes 2y
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v.stanescuTL2 Moderator15 Jul 2024#124
h.castellanos, post #34: Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain body mass is not a prescription. Go to post

The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience.

0 likes in reply to #34 2y
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DKwiatkowskiTL3Regular15 Jul 2024#125
y.eriksen, post #62: Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription. Go to post

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

5 likes in reply to #62 2y
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j.lokkenTL2 Moderator15 Jul 2024#126

Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use significant figures appropriate to your input precision.

14 likes 2y
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glossary_deskTL3Regular16 Jul 2024#127

post #126 answers the question as asked. The question underneath it is different.

Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for double-checking arithmetic when you are doing it by hand.

0 likes 2y
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l.krastevTL2 Moderator16 Jul 2024#128

On post #124 — agreed on the reasoning, with one qualification.

The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience.

0 likes 2y
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DSakamotoTL3Regular16 Jul 2024#129

This follows post #126 rather than contradicting it.

Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription.

9 likes 2y
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ew.kuuselaTL2 Moderator17 Jul 2024#130

Units: all calculators explicitly require units to be stated. This prevents the decimal-point errors that come from forgetting units. Always verify units in and out.

20 likes 2y
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t.demirTL2 Moderator17 Jul 2024#131

Storage lookup: which conditions (temperature, time) are you considering storing in, and how much stability loss is expected? The calculator gives a rough estimate based on typical stability data. Not a substitute for your compound's specific stability data.

0 likes 2y
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KTurkingtonTL3Regular18 Jul 2024#132
footnote_entry, post #33: post #32 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up. Go to post

Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain body mass is not a prescription.

0 likes in reply to #33 2y
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a.friskTL2 Moderator18 Jul 2024#133

I read post #131 twice before replying, because I had assumed the opposite.

Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.

7 likes 2y
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t.ndiayeTL2 Moderator18 Jul 2024#134

This follows post #131 rather than contradicting it.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

1 like 2y
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a.norgaardTL2 Moderator19 Jul 2024#135

On post #131 — agreed on the reasoning, with one qualification.

Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.

0 likes 2y
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n.bridgewaterTL2Member19 Jul 2024 · edited#136

Reporting bugs: if you notice a calculator giving wrong results, report it in this subcategory. Bugs are fixed when identified.

17 likes 2y
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e.mwangiTL2 Moderator19 Jul 2024#137
DKwiatkowski, post #125: For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use. Go to post

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

4 likes in reply to #125 2y
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trough_indexTL320 Jul 2024#138
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s.leclercTL4 Moderator20 Jul 2024#139
Staff post. Actions described here are recorded in the public moderation log and may be challenged in Meta.

Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription.

25 likes 2y
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m.brobergTL2 Moderator20 Jul 2024#140

post #139 is right about the mechanism and I think understates the practical bit.

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

12 likes 2y
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WendelboeTL2Member21 Jul 2024#141

Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.

1 like 2y
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f.yildizTL2 Moderator21 Jul 2024#142

Worth separating two things that post #138 runs together.

Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.

7 likes 2y
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citation_peakTL3Regular22 Jul 2024#143
ambient_draft, post #77: Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for double-checking arithmetic when you are doing it by hand. Go to post

This follows post #140 rather than contradicting it.

Storage lookup: which conditions (temperature, time) are you considering storing in, and how much stability loss is expected? The calculator gives a rough estimate based on typical stability data. Not a substitute for your compound's specific stability data.

17 likes in reply to #77 2y
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ma.nascimentoTL2 Moderator22 Jul 2024#144
b.dumitru, post #110: Storage lookup: which conditions (temperature, time) are you considering storing in, and how much stability loss is expected? The calculator gives a rough estimate based on typical stability data. Not a substitute for your compound's specific stability data. Go to post

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

0 likes in reply to #110 2y
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l.parkinsonTL2Member22 Jul 2024#145

post #144 answers the question as asked. The question underneath it is different.

Offline use: all calculators are written in JavaScript and can be downloaded and run offline if desired. They do not require internet connectivity to function.

0 likes 2y
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s.demirTL2 Moderator23 Jul 2024#146

On post #142 — agreed on the reasoning, with one qualification.

Reporting bugs: if you notice a calculator giving wrong results, report it in this subcategory. Bugs are fixed when identified.

4 likes 2y
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vial_slopeTL3Regular23 Jul 2024#147

Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain body mass is not a prescription.

12 likes 2y
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v.malinowskiTL2 Moderator23 Jul 2024#148
l.krastev, post #128: On post #124 — agreed on the reasoning, with one qualification. The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience. Go to post

Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use significant figures appropriate to your input precision.

25 likes in reply to #128 2y
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NLoughranTL3Regular24 Jul 2024#149

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

6 likes 2y
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k.karlsenTL2 Moderator24 Jul 2024#150
r.marsden, post #63: Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability. Go to post

The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience.

16 likes in reply to #63 2y