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Data & Tools · Calculators · continued

The mass-error checker and its intended scope posts 151–168

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

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cohort_driftTL3Regular24 Jul 2024#151

Coming back to post #149, because the follow-up matters more than the original answer.

Units: all calculators explicitly require units to be stated. This prevents the decimal-point errors that come from forgetting units. Always verify units in and out.

6 likes 2y
SO
s.okonkwoTL2 Moderator25 Jul 2024#152
f.novak, post #72: I read post #70 twice before replying, because I had assumed the opposite. The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience. Go to post

Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for double-checking arithmetic when you are doing it by hand.

1 like in reply to #72 2y
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OTeixeiraTL325 Jul 2024#153
SO
s.oyelaranTL2 Moderator26 Jul 2024#154

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

22 likes 2y
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JFitzgibbonTL2Member26 Jul 2024 · edited#155

I read post #153 twice before replying, because I had assumed the opposite.

Units: all calculators explicitly require units to be stated. This prevents the decimal-point errors that come from forgetting units. Always verify units in and out.

3 likes 2y
SB
s.beaulieuTL2 Moderator26 Jul 2024#156
lyophil_margin, post #58: I read post #56 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

This follows post #153 rather than contradicting it.

The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience.

0 likes in reply to #58 2y
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g.haalandTL3Regular27 Jul 2024#157

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

31 likes 2y
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to.vargaTL2 Moderator27 Jul 2024#158

Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription.

15 likes 2y
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s.duarteTL2 Moderator27 Jul 2024#159

Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.

15 likes 2y
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a.sorensenTL2 Moderator28 Jul 2024#160

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

5 likes 2y
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s.cabreraTL2 Moderator28 Jul 2024#161
OTeixeira, post #92: Worth separating two things that post #88 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

Picking up post #158: that is the part I would want checked first.

Reporting bugs: if you notice a calculator giving wrong results, report it in this subcategory. Bugs are fixed when identified.

8 likes in reply to #92 2y
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PharmNotes_WhitfieldTL4Pharmacist28 Jul 2024#162

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

19 likes 2y
VB
v.baptistaTL2 Moderator29 Jul 2024#163

Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use significant figures appropriate to your input precision.

0 likes 2y
BN
bench_notesTL4 Moderator29 Jul 2024 · edited#164
da.bakker, post #40: The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience. Go to post

On post #160 — agreed on the reasoning, with one qualification.

Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for double-checking arithmetic when you are doing it by hand.

2 likes in reply to #40 2y
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k.fonsecaTL2 Moderator29 Jul 2024#165

Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.

5 likes 2y
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k.vanheckeTL230 Jul 2024#166
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e.lehtinenTL2 Moderator30 Jul 2024#167

post #166 is right about the mechanism and I think understates the practical bit.

Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain body mass is not a prescription.

0 likes 2y
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b.aaltoTL2 Moderator30 Jul 2024#168
r.bruun, post #59: I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient. Go to post

Worth separating two things that post #164 runs together.

Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for double-checking arithmetic when you are doing it by hand.

0 likes in reply to #59 2y

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