Compounds · Cagrilintide & amylin analogues · continued

Why cagrilintide alone is discussed so much less than in combination — does this still hold? posts 31–32

Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

r.bruunTL2 Moderator25 Jul 2026#31

a.vermeulen, post #27: post #26 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up. Go to post

On post #27 — agreed on the reasoning, with one qualification.

Reading the phase 2 paper: it establishes tolerability and efficacy in a selected population on a defined dose escalation. It does not establish the lowest effective dose or the durability over years.

7 likes in reply to #27 3d

TL4_HalvorsenTL427 Jul 2026#32

Collapsed as off-topic by two members at trust level 3 or above

The CagriSema phase 2 paper: a fixed combination of the two components in one weekly injection. The trade-off of a fixed combination is that you cannot titrate the components independently and you cannot attribute effect to one component from a combination trial.

This topic was referenced in

Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind itCompounds › Cagrilintide & amylin analogues · 6 replies
Follow-up: Is "synergy" the right word for the combination data?Compounds › Cagrilintide & amylin analogues · 2 replies

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