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Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 1 of 40

Topic	Participants	Replies	Views	Activity
Correlation in a self-tracked dataset: what it can support Research Methods › Statistics effect size heterogeneity worked example number needed to treat Closed Correlation in a self-tracked dataset: what it can support — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not think it…	+152	166	48k	23mo
Are there stupid questions here? A staff answer, at length Start Here › Welcome beginner friendly guidelines onboarding trust levels Solved Are there stupid questions here? A staff answer, at length I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+122	153	50k	11mo
The mass-error checker and its intended scope Data & Tools › Calculators worked example concentration maths syringe units site feedback The mass-error checker and its intended scope Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+149	167	42k	2y
Journal club: SURMOUNT-1, read without the press release Evidence › Journal club journal club estimand randomised trial number needed to treat Journal club: SURMOUNT-1, read without the press release Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…	+139	157	66k	12mo
A 10 mg vial reconstituted three different ways, compared — the long version Practice › Reconstitution reconstitution syringe units worked example concentration maths A 10 mg vial reconstituted three different ways, compared — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…	+146	158	47k	9mo
Second pass at: A field-by-field walk through a certificate of analysis Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers amino acid analysis Solved Second pass at: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical…	+149	164	36k	19mo
Validating a method you did not develop — does this still hold? Analytics › Method validation stability-indicating method LOD & LOQ precision & repeatability recovery Solved Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means…	+128	148	47k	16mo
Cold packs, phase-change material, and what survives ten days Sourcing › Logistics shipping temperature excursion cold chain customs Cold packs, phase-change material, and what survives ten days — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+132	138	65k	2y
When a preprint is the best available evidence and we say so Evidence › Preprints risk of bias effect size preprint Solved When a preprint is the best available evidence and we say so — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…	+148	160	31k	11mo
Pharmaceutical compounding rules, summarised from primary sources Sourcing › Regulatory MHRA EMA research use only Closed Pharmaceutical compounding rules, summarised from primary sources — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+135	163	46k	17mo
Domestic fridge temperature mapping: a cheap experiment — what changed since Devices › Cold chain cold chain storage freeze-thaw temperature excursion Domestic fridge temperature mapping: a cheap experiment — what changed since — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a…	+145	155	46k	12mo
Oral semaglutide bioavailability and its variability between people — a second dataset Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Closed Oral semaglutide bioavailability and its variability between people — a second dataset — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support…	+141	154	47k	19mo
One lot is one lot: when a report becomes a pattern — the long version Sourcing › Vendor reports third-party testing Janoshik Analytical certificate of analysis batch & lot numbers Closed One lot is one lot: when a report becomes a pattern — the long version — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+137	152	46k	16mo
Research-use-only labelling: what it means and what it does not — the long version Sourcing › Regulatory EMA research use only compounding Posting this under the heading it deserves: Research-use-only labelling: what it means and what it does not — the long version Everything below is what sits behind that. I would like to talk about…	+150	158	55k	14mo
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Compounds › Tirzepatide tirzepatide SURPASS programme randomised trial effect size Solved Closed Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 2 ( Lancet ,…	+150	163	22k	11mo
Retatrutide dose escalation in the published trials Compounds › Retatrutide preprint retatrutide effect size Posting this under the heading it deserves: Retatrutide dose escalation in the published trials Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it…	+149	159	30k	15mo
Second pass at: Metformin co-administration and additive GI effects Practice › Interactions hypoglycaemia delayed gastric emptying metformin needs a source On the subject in the title: Second pass at: Metformin co-administration and additive GI effects Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+131	142	56k	19d
Follow-up: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration tirzepatide dose reduction worked example missed dose Wiki Where the four-week escalation interval comes from, and what it is not Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still…	+131	147	47k	18mo
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations prior authorisation type 2 diabetes telehealth Posting this under the heading it deserves: Preparing for an appointment: one page, three questions Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+139	151	47k	18mo
"Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Solved "Greater than or equal to 99%" as a specification rather than a result Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would…	+132	146	47k	5mo
Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues effect size randomised trial cagrilintide cagrisema Solved Amylin analogue mechanism: satiety signalling separate from GLP-1 — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SCALE ( N Engl J Med , 2015) and…	+128	142	38k	13mo
The anatomy of a question that gets answered within an hour — the long version Start Here › How to Ask onboarding beginner friendly guidelines The anatomy of a question that gets answered within an hour — the long version Writing it up because I had to work it out twice and would rather nobody else did. Question in the title. Context below, and I…	+129	142	49k	8mo
EMA product information as a primary source — does this still hold? Regional › European Union EMA cost per milligram formulary personal import Solved Closed The question in the title: EMA product information as a primary source — does this still hold? I will give what I have already checked below so nobody repeats it. Documenting an access outcome, dated, because…	+127	150	41k	20mo
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Access › Pricing compounding formulary cost per milligram Solved Price changes over 2025 and 2026, tabulated and dated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated,…	+147	156	18k	3mo
When "no data" is the complete and final answer Compounds › Other compounds custom synthesis mislabelling needs a source research use only Solved Asking directly, because I could not find a straight answer: When "no data" is the complete and final answer I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…	+154	165	6.3k	15mo
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club estimand risk of bias number needed to treat Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SUSTAIN 6 ( N Engl…	+108	122	52k	7d
Requesting a page: what makes a good request — what changed since Documentation › Wiki requests promoted to docs review date wiki post Closed Posting this under the heading it deserves: Requesting a page: what makes a good request — what changed since Everything below is what sits behind that. Nominating something for promotion into the…	+126	141	50k	21mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+151	163	9.7k	21mo
Sleep tracking data and its considerable limitations Wellbeing › Sleep heart rate fatigue obstructive sleep apnoea Solved Sleep tracking data and its considerable limitations — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+109	126	61k	9mo
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+135	147	32k	2d

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