Ranked by engagement

Top topics — this year

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,076 topics · page 1 of 14

Topic	Participants	Replies	Views	Activity
Are there stupid questions here? A staff answer, at length Start Here › Welcome beginner friendly guidelines onboarding trust levels Solved Are there stupid questions here? A staff answer, at length I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+122	153	50k	11mo
A 10 mg vial reconstituted three different ways, compared — the long version Practice › Reconstitution reconstitution syringe units worked example concentration maths A 10 mg vial reconstituted three different ways, compared — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…	+146	158	47k	9mo
When a preprint is the best available evidence and we say so Evidence › Preprints risk of bias effect size preprint Solved When a preprint is the best available evidence and we say so — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…	+148	160	31k	11mo
Domestic fridge temperature mapping: a cheap experiment — what changed since Devices › Cold chain cold chain storage freeze-thaw temperature excursion Domestic fridge temperature mapping: a cheap experiment — what changed since — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a…	+145	155	46k	12mo
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Compounds › Tirzepatide tirzepatide SURPASS programme randomised trial effect size Solved Closed Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 2 ( Lancet ,…	+150	163	22k	11mo
Second pass at: Metformin co-administration and additive GI effects Practice › Interactions hypoglycaemia delayed gastric emptying metformin needs a source On the subject in the title: Second pass at: Metformin co-administration and additive GI effects Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+131	142	56k	19d
"Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Solved "Greater than or equal to 99%" as a specification rather than a result Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would…	+132	146	47k	5mo
The anatomy of a question that gets answered within an hour — the long version Start Here › How to Ask onboarding beginner friendly guidelines The anatomy of a question that gets answered within an hour — the long version Writing it up because I had to work it out twice and would rather nobody else did. Question in the title. Context below, and I…	+129	142	49k	8mo
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Access › Pricing compounding formulary cost per milligram Solved Price changes over 2025 and 2026, tabulated and dated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated,…	+147	156	18k	3mo
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club estimand risk of bias number needed to treat Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SUSTAIN 6 ( N Engl…	+108	122	52k	7d
Sleep tracking data and its considerable limitations Wellbeing › Sleep heart rate fatigue obstructive sleep apnoea Solved Sleep tracking data and its considerable limitations — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+109	126	61k	9mo
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+135	147	32k	2d
Titles that describe the question, not the situation Start Here › How to Ask onboarding site feedback guidelines worked example Closed Titles that describe the question, not the situation — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things people…	+139	153	22k	8mo
Coming back to: What published stability data actually covers, and what it does not Practice › Storage & stability cold chain freeze-thaw storage beyond-use date Solved Closed The question in the title: What published stability data actually covers, and what it does not I will give what I have already checked below so nobody repeats it. Practical question with the units stated,…	+136	148	20k	10mo
[2026 update] Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Medutest VendorInvestigate blind sampling third-party testing Solved On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+121	128	51k	17h
Second pass at: Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data ipamorelin tesamorelin needs a source Second pass at: Why this subcategory is stricter about sourcing than most — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-4 ( JAMA ,…	+120	129	61k	11mo
An appeal that succeeded, with the letter structure — the long version Access › Insurance & coverage appeals formulary insurance An appeal that succeeded, with the letter structure — the long version — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that…	+113	136	32k	1mo
Second pass at: A history of disordered eating: proceeding carefully Wellbeing › Mental health disordered eating mood beginner friendly Closed On the subject in the title: Second pass at: A history of disordered eating: proceeding carefully Working notes rather than a conclusion. General question, not a request for advice about my own care — I know…	+125	132	51k	10mo
Revisiting: Language barriers in accessing a prescription abroad Access › International EMA telehealth personal import MHRA Posting this under the heading it deserves: Revisiting: Language barriers in accessing a prescription abroad Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+131	148	28k	5mo
Aggregated purity results across four services, with caveats — a second dataset Data & Tools › Datasets data table confounding site feedback observational data Closed Aggregated purity results across four services, with caveats — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like…	+127	151	42k	10mo
The headache that turns out to be dehydration Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure The headache that turns out to be dehydration Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody…	+143	158	7.8k	6mo
Warfarin and altered intake: the monitoring argument — the long version Practice › Interactions metformin needs a source delayed gastric emptying hypoglycaemia Solved Posting this under the heading it deserves: Warfarin and altered intake: the monitoring argument — the long version Everything below is what sits behind that. Reporting something rather than asking about it,…	+123	134	40k	4mo
Asking about a compound your prescriber has not heard of Clinical › Prescriber conversations telehealth prior authorisation beginner friendly Asking about a compound your prescriber has not heard of Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+137	148	15k	11mo
Temperature loggers worth the money — the long version Devices › Cold chain storage freeze-thaw temperature excursion Closed On the subject in the title: Temperature loggers worth the money — the long version Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…	+110	127	48k	6mo
Follow-up: The decimal-point error, and the habit that catches it Practice › Reconstitution concentration maths bacteriostatic water dead volume reconstitution Closed On the subject in the title: The decimal-point error, and the habit that catches it Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking…	+118	131	50k	7mo
What happens after your first post: likes, trust levels, and why none of it matters much — what changed since Start Here › Welcome onboarding beginner friendly trust levels guidelines Solved The question in the title: What happens after your first post: likes, trust levels, and why none of it matters much — what changed since I will give what I have already checked below so nobody repeats it. I…	+105	118	57k	9mo
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Compounds › Tirzepatide SURMOUNT programme randomised trial tirzepatide SURPASS programme Solved Closed Posting this under the heading it deserves: SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med…	+122	136	48k	9mo
Measurement error in a self-reported exposure Evidence › Study critique confounding risk of bias effect size disputed Solved Closed Posting this under the heading it deserves: Measurement error in a self-reported exposure Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it before…	+117	129	45k	5mo
Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter third-party testing Interpreting a result that disagrees with the supplier's certificate Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+129	153	7.3k	5mo
What consumer-accessible tests can and cannot determine — a second dataset Analytics › Home & field testing ELISA LOD & LOQ third-party testing documentation quality Solved What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know…	+117	131	45k	10h

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