Ranked by engagement

Top topics — this year page 6

Ranked by replies, likes and views over this year, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,076 topics · page 6 of 14

Topic	Participants	Replies	Views	Activity
Journal club: indirect comparison between two programmes, defended and attacked Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016)…	+122	131	5.2k	just now
List price versus negotiated price versus what you pay Access › Pricing formulary data table compounding Under review On the subject in the title: List price versus negotiated price versus what you pay Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires.…	+99	115	11k	3mo
What this community means by "a source", in practical terms Start Here › Welcome beginner friendly trust levels guidelines Solved Asking directly, because I could not find a straight answer: What this community means by "a source", in practical terms Question in the title. Context below, and I have tried to include the things people…	+107	122	1.9k	10mo
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Clinical › Special populations chronic kidney disease disordered eating older adults Solved Second pass at: Pregnancy and pregnancy planning: contraindication and washout Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a…	+111	127	1.6k	6mo
Molecular mass of semaglutide and why the figure differs between sources Compounds › Semaglutide SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 4 ( JAMA , 2021)…	+101	110	12k	16h
The lowest dose that does anything: is that a real question? Practice › Dosing & titration dose reduction worked example missed dose titration Asking directly, because I could not find a straight answer: The lowest dose that does anything: is that a real question? I have read the maintained page on this and I still have a gap, so I am asking rather…	+100	111	9.1k	5mo
CJC-1295 with and without DAC: what the modification does Compounds › Secretagogues & GH axis needs a source tesamorelin CJC-1295 GHRP class On the subject in the title: CJC-1295 with and without DAC: what the modification does Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with SURMOUNT-OSA ( N Engl J Med ,…	+117	123	5.6k	22h
A request that was declined, and the reasoning — a second dataset Documentation › Wiki requests maintainership promoted to docs wiki post Closed A request that was declined, and the reasoning — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the…	+89	98	31k	11mo
Preprint servers and what screening they do Evidence › Preprints preprint effect size needs a source Preprint servers and what screening they do — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+95	106	5.6k	4mo
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Compounds › Tirzepatide tirzepatide SURPASS programme effect size randomised trial Closed Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med ,…	+89	101	32k	8mo
Second pass at: The topic list is dense — is that deliberate? Meta › Site feedback site feedback moderation guidelines Solved Second pass at: The topic list is dense — is that deliberate? I have a specific reason for asking rather than idle curiosity, and the context is below. Nominating something for promotion into the…	+102	108	8.4k	4mo
What a certificate commits its issuer to — one year on Analytics › COA interpretation reference standards certificate of analysis documentation quality batch & lot numbers Wiki What a certificate commits its issuer to — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. A documentation question rather than an analytical one. I have a…	+107	117	6.5k	1d
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Devices › Syringes & needles syringe units subcutaneous injection needle gauge & length dead volume Wiki 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how quickly…	+104	114	6k	6d
Injecting into an area that has become firm: why not to Practice › Administration subcutaneous injection injection site rotation injection site reaction aseptic technique Solved Injecting into an area that has become firm: why not to Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+82	92	26k	1mo
Reading SURMOUNT-1 without the press release Compounds › Tirzepatide SURMOUNT programme effect size randomised trial SURPASS programme Posting this under the heading it deserves: Reading SURMOUNT-1 without the press release Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a claim I do not…	+103	121	7k	7mo
Distinguishing expected GI effects from something that needs urgent attention Practice › Side effects nausea hair shedding vomiting delayed gastric emptying Closed Distinguishing expected GI effects from something that needs urgent attention Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about…	+88	101	32k	6mo
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Lounge › Introductions beginner friendly onboarding Posting this under the heading it deserves: Introducing myself: pharmacist, sceptic, reluctant participant — one year on Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule…	+101	107	14k	4mo
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Practice › Administration injection site reaction needle gauge & length aseptic technique injection site rotation Rotating between abdomen, thigh and upper arm: absorption differences — one year on — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still…	+82	102	24k	just now
When to stop reading forums, including this one Wellbeing › Mental health mood disordered eating beginner friendly When to stop reading forums, including this one I have a specific reason for asking rather than idle curiosity, and the context is below. General question, not a request for advice about my own care — I know…	+78	86	47k	6mo
Foaming during reconstitution and whether it matters — the long version Practice › Reconstitution reconstitution bacteriostatic water worked example concentration maths Foaming during reconstitution and whether it matters — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…	+100	117	6k	3mo
A preprint whose numbers changed substantially at publication Evidence › Preprints preprint needs a source effect size Wiki Closed A preprint whose numbers changed substantially at publication — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read it before posting;…	+90	95	21k	9mo
Coming back to: Resolution and tailing factor: real acceptance criteria Analytics › HPLC & UHPLC peak integration data table UV & DAD detection Posting this under the heading it deserves: Resolution and tailing factor: real acceptance criteria Everything below is what sits behind that. Posting the method first, because I know what the first three…	+93	112	5.7k	9mo
Dizziness on standing and the electrolyte explanation — does this still hold? Practice › Side effects vomiting hair shedding nausea constipation Solved The question in the title: Dizziness on standing and the electrolyte explanation — does this still hold? I will give what I have already checked below so nobody repeats it. I have read the maintained page on…	+89	94	18k	1mo
Second pass at: Which categories are strict and which are relaxed, honestly Start Here › Welcome guidelines beginner friendly trust levels onboarding Wiki On the subject in the title: Second pass at: Which categories are strict and which are relaxed, honestly Working notes rather than a conclusion. Question in the title. Context below, and I have tried to…	+93	99	36k	3d
Here for the analytics and not much else Lounge › Introductions onboarding beginner friendly Here for the analytics and not much else — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something…	+93	102	10k	16h
Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import cost per milligram MHRA Pinned On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+66	76	46k	14h
Why oral semaglutide needs an absorption enhancer at all Compounds › Oral incretins randomised trial orforglipron oral semaglutide SOUL trial Solved Why oral semaglutide needs an absorption enhancer at all I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of…	+59	65	61k	7mo
Why fasting instructions for oral semaglutide are not optional advice — does this still hold? Compounds › Oral incretins orforglipron SOUL trial PIONEER programme randomised trial Solved Asking directly, because I could not find a straight answer: Why fasting instructions for oral semaglutide are not optional advice — does this still hold? Session topic: PIONEER 6 ( N Engl J Med , 2019).…	+98	106	3.1k	10mo
Revisiting: What pooling buys you and what it destroys Evidence › Meta-analyses heterogeneity effect size publication bias Solved On the subject in the title: Revisiting: What pooling buys you and what it destroys Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+97	107	4k	19h
How the vendor documentation pages are maintained, and by whom — what changed since Sourcing › Vendor reports third-party testing disputed batch & lot numbers Solved Asking directly, because I could not find a straight answer: How the vendor documentation pages are maintained, and by whom — what changed since A logistics question, since the answers here are usually better…	+98	104	3k	8mo