e.tamm

TL2 Moderator · Uppsala

Contributes reviews on supplier material. Based in Uppsala.

Joined 8 October 2024 · last posted 4d

86 posts, newest first. Showing up to 150.

Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #30 · Evidence › Meta-analyses · 24 Jul 2026 · 0 likes I read post #28 twice before replying, because I had assumed the opposite. Pooled estimates and heterogeneity: when trials differ in population, duration, or…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #75 · Start Here › Welcome · 23 Jul 2026 · 18 likes This follows post #72 rather than contradicting it. For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add…
Revisiting: Protein density versus volume when you cannot eat much Replied, post #83 · Nutrition & Training › Protein & intake · 19 Jul 2026 · 7 likes Worth separating two things that post #79 runs together. Micronutrition alongside protein: eating protein foods that are also good sources of micronutrients (iron, B…
GIP receptor agonism and the argument about direction — does this still hold? Replied, post #11 · Pharmacology › Receptor biology · 17 Jul 2026 · 0 likes Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #82 · Evidence › Journal club · 5 Jul 2026 · 3 likes post #81 answers the question as asked. The question underneath it is different. SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an…
Why the timeline is on the right and not the left — what changed since Replied, post #65 · Meta › Site feedback · 1 Jul 2026 · 0 likes On post #61 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #50 · Compounds › Oral incretins · 20 Jun 2026 · 18 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
An appeal that succeeded, with the letter structure — the long version Replied, post #120 · Access › Insurance & coverage · 19 Jun 2026 · 25 likes post #119 answers the question as asked. The question underneath it is different. Documentation your clinician can provide: letters from clinicians describing why…
GLP-1 receptor distribution: central and peripheral Replied, post #71 · Pharmacology › Receptor biology · 17 Jun 2026 · 0 likes Worth separating two things that post #67 runs together. Glucagon receptor agonism: glucagon receptor agonism increases energy expenditure and promotes hepatic fat…
Submitting a sample: the process end to end Replied, post #13 · Sourcing › Independent verification · 12 Jun 2026 · 2 likes Janoshik Analytical: chromatographic purity and mass-spectrometric identity on submitted samples. Reports are issued with the analytical method stated and a…
Official shortage notices and what they authorise Replied, post #98 · Access › Shortages · 10 Jun 2026 · 30 likes Resuming after a gap: after a gap of days or a few weeks, most people resume at the dose they were on when they stopped. Gaps of months might require retitration…
Micronutrient adequacy at low total intake Replied, post #40 · Nutrition & Training › Protein & intake · 9 Jun 2026 · 8 likes Fibre: adequate fibre intake supports fullness and gut motility, both of which matter during the gastrointestinal effects of these compounds. High fibre on top of…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #98 · Sourcing › Red flags · 6 Jun 2026 · 32 likes Evasion when asked: if a supplier does not clarify when asked specifically for method details, counter-ion form, or batch origin, that itself is a red flag worth…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #39 · Analytics › Home & field testing · 5 Jun 2026 · 22 likes Coming back to post #37, because the follow-up matters more than the original answer. Sample handling matters: if a sample is contaminated or degraded before testing,…
What a certificate commits its issuer to — one year on Replied, post #74 · Analytics › COA interpretation · 24 May 2026 · 11 likes This follows post #71 rather than contradicting it. When a document puts the specification in the result column, it has told you the release criterion, not the…
Bariatric surgery history: altered anatomy, altered expectations Replied, post #12 · Clinical › Special populations · 17 May 2026 · 25 likes Picking up post #9: that is the part I would want checked first. Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #26 · Analytics › HPLC & UHPLC · 13 May 2026 · 18 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
How this community labels and discusses unrefereed work — the long version Replied, post #6 · Evidence › Preprints · 10 May 2026 · 1 like I read post #4 twice before replying, because I had assumed the opposite. Unrefereed work is not worthless. A great deal of it survives review substantially unchanged.…
What I would want from a home test that does not exist yet — what changed since Replied, post #9 · Analytics › Home & field testing · 2 May 2026 · 4 likes Molecular tests: DNA or RNA tests are not applicable to peptides, which do not contain nucleic acids. Peptide-specific tests rely on protein recognition, not…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #95 · Compounds › Tirzepatide · 24 Apr 2026 · 16 likes SURMOUNT-OSA is notable because it used an objective physiological endpoint, the apnoea-hypopnoea index, rather than a symptom scale. Two parallel trials, with and…
EU-wide position versus national implementation — what changed since Replied, post #23 · Regional › European Union · 14 Apr 2026 · 0 likes EMA is the regulator with national implementation. Licensed incretin analogues are prescription-only across the EU, with some variation in specific approvals by member…
Amylin receptor signalling and satiety — what changed since Replied, post #59 · Pharmacology › Receptor biology · 10 Apr 2026 · 1 like Worth separating two things that post #55 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
Revisiting: Absolute versus relative contraindications Replied, post #49 · Safety › Contraindications · 22 Mar 2026 · 17 likes On post #45 — agreed on the reasoning, with one qualification. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #71 · Compounds › Cagrilintide & amylin analogues · 17 Mar 2026 · 0 likes This follows post #68 rather than contradicting it. For anyone arriving from searches on "amylin agonist": this subcategory discusses published clinical evidence and…
Oral versus injected administration claims for BPC-157 Replied, post #15 · Compounds › Repair & healing peptides · 14 Mar 2026 · 0 likes The distinction between "no evidence it works" and "evidence it does not work": we have the first for these compounds. That is genuinely different from the second and…
CJC-1295 with and without DAC: what the modification does Replied, post #12 · Compounds › Secretagogues & GH axis · 13 Mar 2026 · 0 likes post #11 is right about the mechanism and I think understates the practical bit. Secretagogues and glucose tolerance: there is a mechanistic concern that sustained…
Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #23 · Practice › Dosing & titration · 11 Mar 2026 · 5 likes On post #19 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
Reused chromatograms across lots: how to spot it — what changed since Replied, post #19 · Analytics › COA interpretation · 22 Feb 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #122 · Practice › Dosing & titration · 21 Feb 2026 · 5 likes The four-week escalation interval is a convention from the pivotal trials, not a pharmacological constant. The pharmacological argument is that with a week-long…
Journal club: LEADER as the historical anchor Replied, post #26 · Evidence › Journal club · 23 Jan 2026 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #51 · Clinical › Bloodwork · 14 Jan 2026 · 0 likes Worth separating two things that post #47 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
Reading an interaction checker output critically Replied, post #66 · Practice › Interactions · 14 Dec 2025 · 0 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long… Replied, post #64 · Compounds › Tirzepatide · 9 Dec 2025 · 1 like Mass and charge states: tirzepatide is about 4813.5 Da and on an electrospray instrument you would expect to see charge states mostly in the 2+ to 4+ range, the same as…
Titles that describe the question, not the situation Replied, post #154 · Start Here › How to Ask · 20 Nov 2025 · 12 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #33 · Start Here › How to Ask · 17 Nov 2025 · 13 likes This follows post #30 rather than contradicting it. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #68 · Compounds › Tirzepatide · 22 Oct 2025 · 0 likes Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading directly rather than through summarised claims. Reconstituted…
A comparison of home results against a laboratory result on the same vial Replied, post #50 · Analytics › Home & field testing · 16 Oct 2025 · 5 likes On post #46 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
New subcategory: rationale and scope Replied, post #33 · Meta › Announcements · 16 Oct 2025 · 3 likes Staff-only posts: some announcements are visible only to staff (concerning internal operations). Members see public announcements.
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #12 · Start Here › Welcome · 12 Oct 2025 · 4 likes I read post #10 twice before replying, because I had assumed the opposite. Marked solutions are the site's way of saying that someone asked a good question and someone…
Which panel is worth repeating and which is worth ignoring Replied, post #128 · Clinical › Bloodwork · 4 Oct 2025 · 0 likes I read post #126 twice before replying, because I had assumed the opposite. Fasting state: some lab tests require fasting; others do not. Lipids on a fasting draw…
Second pass at: What "verified" means on our vendor pages, stated narrowly Replied, post #20 · Sourcing › Vendor reports · 30 Sep 2025 · 0 likes Coming back to post #18, because the follow-up matters more than the original answer. Blind submission is worth the effort: have someone else relabel the sample so…
High-resolution MS on aggregates and what it can see Replied, post #80 · Analytics › Mass spectrometry · 29 Sep 2025 · 3 likes post #79 answers the question as asked. The question underneath it is different. Mass accuracy is expressed in parts per million. It is the difference between observed…
Discussing something you have already been doing Replied, post #10 · Clinical › Prescriber conversations · 28 Sep 2025 · 11 likes I read post #8 twice before replying, because I had assumed the opposite. What to bring: copies of relevant lab results, pharmacy records (to confirm doses actually…
Payment method and the leverage it gives you, ranked Replied, post #53 · Sourcing › Payments · 22 Sep 2025 · 6 likes On post #49 — agreed on the reasoning, with one qualification. Documentation and tax implications: payments you make for compounds might have implications for tax…
Confounding by indication, explained with a concrete example Replied, post #15 · Evidence › Study critique · 1 Sep 2025 · 7 likes Generalisability: do the inclusion/exclusion criteria narrow the population so much that results do not apply to real people asking about it? This is a fair criticism…
Pages past their review date, listed Replied, post #25 · Meta › Wiki maintenance · 1 Sep 2025 · 0 likes On post #21 — agreed on the reasoning, with one qualification. Redundancy: if two maintained pages cover largely the same ground, consolidation might improve clarity.…
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #32 · Analytics › Mass spectrometry · 30 Aug 2025 · 0 likes Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect mostly 2+, 3+, and 4+ charge states. Reading an electrospray spectrum means…
[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #68 · Compounds › Retatrutide · 28 Aug 2025 · 0 likes Worth separating two things that post #64 runs together. How to read phase 2 without treating it as phase 3: phase 2 establishes that a dose range produces an effect…
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #48 · Compounds › Semaglutide · 26 Aug 2025 · 24 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
Hypertension improvement and when medication needs revisiting Replied, post #24 · Clinical › Comorbidities · 25 Aug 2025 · 3 likes Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for oral medications and for reconstituted solutions. Discussing specific…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #75 · Evidence › Journal club · 20 Aug 2025 · 5 likes Worth separating two things that post #71 runs together. SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological…
Research-use-only status: what it means legally and practically — does this still hold? Replied, post #2 · marked as the solution · Compounds › Other compounds · 30 Jul 2025 · 24 likes This subcategory exists because some people will research compounds outside the main groups discussed here. The standard of evidence and honesty about its limits…
Sequence verification for an obscure compound: how it is done Replied, post #93 · Compounds › Other compounds · 15 Jul 2025 · 24 likes Picking up post #90: that is the part I would want checked first. Reading a supplier's product description as a marketing document: that is exactly what it is. The…
Cross-border purchase within the EU: the actual rules Replied, post #5 · Access › International · 14 Jul 2025 · 31 likes Travel with medication: carrying a compound across borders is complicated by legal status. Documenting that it is prescribed and carrying proof reduces (but does not…
Gauge and length selection for subcutaneous injection Replied, post #11 · Devices › Syringes & needles · 11 Jul 2025 · 0 likes post #10 is right about the mechanism and I think understates the practical bit. Aspirating before injection: for subcutaneous injection, aspirating (pulling back on…
Second pass at: Semaglutide and alcohol: what is actually documented Replied, post #15 · Compounds › Semaglutide · 18 Jun 2025 · 0 likes post #14 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Merging two pages that cover the same ground Replied, post #2 · Documentation › Wiki requests · 7 Jun 2025 · 11 likes Authority and authorship: if you think a maintained page needs input from someone with specific expertise (a clinician, an analytical chemist) suggest who might…
Why "any advice?" is the least effective ending for a post — the long version Replied, post #7 · Start Here › How to Ask · 28 May 2025 · 7 likes Chromatogram questions: describe the method first. Column type, gradient, wavelength, detection method. Everything else follows from method. A chromatogram without…
Second pass at: Pen dose counters: what a click does and does not guarantee Replied, post #51 · Devices › Pens & autoinjectors · 28 May 2025 · 23 likes This follows post #48 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
About the Contraindications category Replied, post #3 · Safety › Contraindications · 21 May 2025 · 20 likes As a member rather than staff: the most useful thing I did when I started reading this category was to work through the tag pages rather than the topic list. The topic…
Asking about a compound your prescriber has not heard of Replied, post #37 · Clinical › Prescriber conversations · 12 May 2025 · 6 likes post #36 answers the question as asked. The question underneath it is different. Discussing off-label dosing: if you want to dose differently than the label specifies…
Counter-ion content and its effect on measured mass Replied, post #29 · Analytics › Mass spectrometry · 1 May 2025 · 0 likes Desalting before analysis: some samples need desalting to remove salts that suppress the peptide signal. Report whether desalting was used, because it can affect the…
Journal club: indirect comparison between two programmes, defended and attacked — one… Replied, post #4 · Evidence › Journal club · 23 Apr 2025 · 0 likes TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not finished. When it does, this discussion will return to it.
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #78 · Compounds › Semaglutide · 15 Apr 2025 · 22 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Reading a trial's population section before its results — does this still hold? Replied, post #8 · Evidence › Trials · 13 Apr 2025 · 1 like Generalisability: the enrolled population was selected in ways that matter. Entry criteria, run-in periods, and the simple fact that people who agree to a multi-year…
Reading order for a first week here, and what to skip until later Replied, post #73 · Start Here › Welcome · 8 Apr 2025 · 0 likes post #72 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
Antibiotics and a course of something with delayed emptying Replied, post #16 · Practice › Interactions · 7 Apr 2025 · 5 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
Filing a first vendor report: a worked example Replied, post #4 · Sourcing › Vendor reports · 27 Mar 2025 · 7 likes Disputed records: when a result disagreed and was not explained, the record says disputed and stays that way. We do not remove inconvenient history; we document it.
Second pass at: Domestic fridge temperature mapping: a cheap experiment Replied, post #3 · marked as the solution · Devices › Cold chain · 24 Mar 2025 · 15 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Maintainer handover: how it works Replied, post #66 · Meta › Wiki maintenance · 18 Mar 2025 · 2 likes Scope creep: if a page is attempting too much, suggesting it split into multiple pages can improve clarity.
A supplier that answers analytical questions with restated claims Replied, post #36 · Sourcing › Red flags · 9 Mar 2025 · 21 likes Exaggerated claims without documentation: every compound has limits. No peptide is "100% pure" because purity is measured to finite precision. A supplier claiming…
Consistent declarations and why they matter more than clever ones Replied, post #119 · Sourcing › Logistics · 3 Mar 2025 · 0 likes Reshipment after seizure: if a parcel is seized, some suppliers will reship; others will not. That is a supplier choice and should be understood before ordering in a…
Second pass at: Regression to the mean in progress reports Replied, post #74 · Research Methods › Statistics · 3 Mar 2025 · 2 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #20 · Sourcing › Regulatory · 28 Feb 2025 · 2 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption. The…
The report format the maintainers ask for, and why each field is there — what changed… Replied, post #8 · Sourcing › Vendor reports · 4 Feb 2025 · 31 likes Picking up post #5: that is the part I would want checked first. Temporal patterns: if results from a supplier were good two years ago but have deteriorated recently,…
What changed in 2026, by region Replied, post #113 · Access › International · 1 Feb 2025 · 0 likes post #112 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
Scheduled maintenance and what will be unavailable Replied, post #19 · Meta › Announcements · 19 Jan 2025 · 10 likes When announcements are made: major policy changes, technical changes affecting site function, planned downtime, and changes to guidelines all get announced here.
Coming back to: Renal impairment: what the labelling says about dose Replied, post #26 · Clinical › Special populations · 2 Jan 2025 · 7 likes Disordered eating history: a history of anorexia nervosa, bulimia, or other eating disorders changes the risk-benefit calculation because appetite suppression might…
SNAC and the mechanism of oral peptide absorption — the long version Replied, post #20 · Compounds › Oral incretins · 1 Jan 2025 · 0 likes Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water measurably reduces absorption. This is the one compound in…
Injection-site reactions: describing them precisely enough to be useful Replied, post #27 · Practice › Side effects · 26 Nov 2024 · 0 likes I read post #25 twice before replying, because I had assumed the opposite. Delayed gastric emptying: the mechanism behind much of the gastrointestinal side-effect…
Promotion criteria, and the one that stops most nominations Replied, post #100 · Documentation › Doc review · 31 Oct 2024 · 16 likes I read post #98 twice before replying, because I had assumed the opposite. Citation checking: if a maintained page cites a paper, the citation should match what the…
Food noise reducing and the disorientation that can follow Replied, post #26 · Wellbeing › Mental health · 22 Oct 2024 · 7 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
A page that has drifted out of date and needs a maintainer Replied, post #14 · Documentation › Wiki requests · 30 Sep 2024 · 28 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Correlation in a self-tracked dataset: what it can support Replied, post #107 · Research Methods › Statistics · 24 Aug 2024 · 4 likes Absence of evidence and evidence of absence: if a study is small and finds no effect, that is absence of evidence, not evidence of absence. A larger study might find an…
Transit times by route, from a logged dataset — the long version Replied, post #2 · Sourcing › Logistics · 27 Jul 2024 · 1 like Worth separating two things that the opening post runs together. Reshipment after seizure: if a parcel is seized, some suppliers will reship; others will not. That is a…
Journal club: FLOW and the renal composite, component by component Replied, post #40 · Evidence › Journal club · 12 Jul 2024 · 0 likes Picking up post #37: that is the part I would want checked first. Session format: read the paper before posting. The discussion is much better when everyone has. Start…