h.jansen

TL2 Moderator · Ibadan

Contributes reviews on supplier material. Based in Ibadan.

Joined 11 December 2024 · last posted 9d

80 posts, newest first. Showing up to 150.

Why the Start Here categories exist, and what they are not for Replied, post #11 · Start Here › Welcome · 18 Jul 2026 · 3 likes I read post #9 twice before replying, because I had assumed the opposite. Trust levels accumulate over time and they give you access to small things like the ability to…
Substitution between formats during a shortage — what changed since Replied, post #15 · Access › Shortages · 15 Jul 2026 · 0 likes Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #44 · Practice › Dosing & titration · 7 Jul 2026 · 19 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Journal club: what we got wrong in an earlier session Replied, post #58 · Evidence › Journal club · 6 Jul 2026 · 25 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #12 · Start Here › Welcome · 5 Jul 2026 · 23 likes The moderation log is public. Every staff action is logged with the rule cited and the reasoning stated. If you get moderated, the explanation is there and it is worth…
Lipid changes during rapid weight loss: the expected trajectory Replied, post #7 · Clinical › Bloodwork · 24 Jun 2026 · 6 likes This follows post #4 rather than contradicting it. Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty…
Alcohol: what is documented and what is folklore Replied, post #69 · Practice › Interactions · 21 Jun 2026 · 3 likes Insulin interaction: semaglutide and tirzepatide are not contraindicated with insulin but the combination carries hypoglycemia risk if insulin doses are not adjusted.…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #61 · Wellbeing › Sleep · 17 Jun 2026 · 9 likes post #60 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
Reading a home test result without over-claiming Replied, post #69 · Analytics › Home & field testing · 6 Jun 2026 · 0 likes Molecular tests: DNA or RNA tests are not applicable to peptides, which do not contain nucleic acids. Peptide-specific tests rely on protein recognition, not…
The most useful thing you learned here that was not the answer you came for Replied, post #48 · Lounge › Off topic · 6 Jun 2026 · 4 likes Adjacent and interesting: you might post something about nutrition, bioavailability from a food perspective, or the sociology of weight. Adjacent to this community's…
Revisiting: The best-written scientific paper you have read Replied, post #9 · Lounge › Off topic · 31 May 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #44 · Practice › Administration · 22 May 2026 · 3 likes Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It is not always necessary and shallower angles can work, but 90 degrees into a small…
Measurement error in home scales, with a worked standard deviation — the long version Replied, post #103 · Research Methods › Statistics · 13 May 2026 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
[2026 update] Waist circumference technique and its repeatability Replied, post #6 · Outcomes › Progress reports · 28 Apr 2026 · 29 likes Non-scale victories: muscle gain or maintenance, clothing fit, energy level, and capability (like climbing stairs without breathlessness) are measurements that…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #111 · Analytics › Mass spectrometry · 24 Apr 2026 · 6 likes post #110 is right about the mechanism and I think understates the practical bit. Charge states observed: for semaglutide (4113.6 Da) the doubly charged ion appears at…
Converting between mg/mL and units per dose, both directions — the long version Replied, post #97 · Practice › Reconstitution · 24 Apr 2026 · 3 likes Over-dilution: if your target dose is 0.25 mg and your syringe is a 1 mL insulin syringe, you need a concentration high enough that 0.25 mg fits on the scale. A 0.25…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Replied, post #40 · Sourcing › Independent verification · 19 Apr 2026 · 2 likes Coming back to post #38, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
Forced degradation studies: designing one that is informative Replied, post #36 · Analytics › Method validation · 13 Apr 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Prediction intervals and why they are more honest than confidence intervals Replied, post #9 · Evidence › Meta-analyses · 4 Apr 2026 · 0 likes Number needed to treat from a meta-analysis: can be computed from the pooled estimate if the baseline risk is specified. More interpretable than pooled relative effects.
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #83 · Lounge › Introductions · 16 Mar 2026 · 17 likes No spam: introductions are not a place to advertise commercial products or services. That is a rules violation.
Five questions in one post gets you one answer — how to split them Replied, post #28 · Start Here › How to Ask · 10 Mar 2026 · 33 likes Disagreeing with an answer you got: cite what you disagree with, say what contradicts it, and ask which one holds. Do not open with "I think you are wrong". Lead with…
Foaming during reconstitution and whether it matters — the long version Replied, post #57 · Practice › Reconstitution · 9 Mar 2026 · 0 likes post #56 answers the question as asked. The question underneath it is different. Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #8 · Compounds › Cagrilintide & amylin analogues · 15 Feb 2026 · 0 likes For anyone arriving from searches on "amylin agonist": this subcategory discusses published clinical evidence and what it does and does not establish. It does not…
Coverage in the US: a map of the usual obstacles Replied, post #51 · Regional › North America · 14 Feb 2026 · 15 likes Picking up post #48: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #74 · Documentation › Wiki requests · 6 Feb 2026 · 15 likes Worth separating two things that post #70 runs together. Suggesting content for a page: if you know a maintained page is missing something important, post a suggestion…
Cardiovascular risk: reading the outcome trials as a set Replied, post #4 · Clinical › Comorbidities · 3 Feb 2026 · 28 likes Picking up the opening post: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the…
Trifluoroacetate content and its consequences Replied, post #16 · Analytics › Impurities & related substances · 24 Jan 2026 · 0 likes I read post #14 twice before replying, because I had assumed the opposite. Acetate content: counter-ion content. Trifluoroacetate or acetate from the salt form of the…
Anaesthesia and elective surgery: the aspiration question Replied, post #3 · Practice › Interactions · 20 Jan 2026 · 0 likes Thyroid medications: semaglutide is associated with a slowing of gastric emptying, which might affect thyroid medication absorption if they are taken very close…
A plateau that disappeared when I changed how I measured Replied, post #9 · Outcomes › Progress reports · 18 Jan 2026 · 31 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #88 · Compounds › Semaglutide · 8 Jan 2026 · 0 likes On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #9 · Sourcing › Logistics · 18 Dec 2025 · 0 likes post #8 answers the question as asked. The question underneath it is different. Customs holds: if a parcel is held at customs and you can contact customs directly,…
Publishing an inconvenient result: a case study — the long version Replied, post #68 · Sourcing › Independent verification · 12 Dec 2025 · 0 likes Picking up post #65: that is the part I would want checked first. Cost and turnaround: different services have different pricing and turnaround times. Janoshik's…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #33 · Access › Pricing · 9 Dec 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Where the integrator drew the baseline, and how much it moved the number Replied, post #21 · Analytics › HPLC & UHPLC · 20 Nov 2025 · 1 like Coming back to post #19, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
Comparing two chromatograms from different laboratories, properly Replied, post #32 · Analytics › HPLC & UHPLC · 19 Nov 2025 · 26 likes post #31 answers the question as asked. The question underneath it is different. Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to…
Lurking for two months before posting: was that the right call? Replied, post #40 · Start Here › Welcome · 19 Nov 2025 · 0 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Pen dose counters: what a click does and does not guarantee Replied, post #13 · Devices › Pens & autoinjectors · 13 Nov 2025 · 9 likes Injection duration: most pens deliver the dose over several seconds. Holding the button down for the full duration ensures complete delivery. Releasing early can result…
[2026 update] What steady state means for the decision to escalate Replied, post #38 · Practice › Dosing & titration · 8 Nov 2025 · 27 likes Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long half-life, which gives a slowly changing plasma level from a…
Titles that describe the question, not the situation Replied, post #133 · Start Here › How to Ask · 27 Oct 2025 · 14 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Moderation log format change Replied, post #5 · Meta › Announcements · 27 Oct 2025 · 13 likes Implementation timeline: announcements include when a change takes effect. Marking the date helps you know whether the change is already in effect.
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #107 · Compounds › Tirzepatide · 23 Oct 2025 · 0 likes Coming back to post #105, because the follow-up matters more than the original answer. The GIP component: GIP receptor agonism is thought to amplify the GLP-1 effect on…
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #145 · Practice › Reconstitution · 15 Oct 2025 · 4 likes Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
Interim analyses and stopping rules Replied, post #2 · Evidence › Trials · 11 Oct 2025 · 18 likes Confounding in observational data: a third variable can explain an apparent association. In a randomised trial, randomisation balances unknown confounders. In…
The nausea timeline across the first four weeks, with a tabulated log Replied, post #131 · Practice › Side effects · 8 Oct 2025 · 28 likes Delayed gastric emptying: the mechanism behind much of the gastrointestinal side-effect profile. At extreme magnitudes, severe gastroparesis is a rare but serious…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #41 · Compounds › Oral incretins · 22 Sep 2025 · 14 likes Trial adherence in an oral trial with strict administration requirements is genuinely worse than trial-published data often suggests. That is why the exposure…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #7 · Evidence › Study critique · 12 Sep 2025 · 2 likes Choosing the worst interpretation: "The confidence interval includes a harmful effect" is true if the CI goes from -1 to +5. But assuming the worst-case scenario is not…
Why the timeline is on the right and not the left Replied, post #64 · Meta › Site feedback · 5 Sep 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Replied, post #34 · Practice › Dosing & titration · 31 Aug 2025 · 0 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
Enforcement priorities versus written rules — does this still hold? Replied, post #18 · Sourcing › Regulatory · 19 Aug 2025 · 11 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
A request that was declined, and the reasoning — a second dataset Replied, post #27 · Documentation › Wiki requests · 8 Aug 2025 · 0 likes Coming back to post #25, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #151 · Compounds › Tirzepatide · 30 Jul 2025 · 0 likes On post #147 — agreed on the reasoning, with one qualification. Titration schedules for tirzepatide have more dose steps than semaglutide partly because the compound is…
Counter-ion content and its effect on measured mass Replied, post #86 · Analytics › Mass spectrometry · 8 Jul 2025 · 11 likes I read post #84 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #80 · Wellbeing › Mental health · 30 Jun 2025 · 2 likes Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #56 · Clinical › Comorbidities · 21 Jun 2025 · 0 likes PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data on compounds in this class in PCOS specifically is…
A report I filed that turned out to be wrong, and the correction Replied, post #83 · Sourcing › Vendor reports · 2 Jun 2025 · 0 likes What "verified" means on our pages: specific lots were independently measured on stated dates by named services and results were consistent with the supplier's…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Replied, post #73 · Practice › Reconstitution · 19 May 2025 · 0 likes The decimal-point error: computing 5 mg / 2 mL as 0.25 mg/mL instead of 2.5 mg/mL is the most common arithmetic error in this subcategory. The habit that catches it:…
Sequence verification for an obscure compound: how it is done Replied, post #37 · Compounds › Other compounds · 17 May 2025 · 2 likes AOD-9604 is a fragment of human growth hormone and has been discussed as a potential weight-loss agent based on theoretical mechanism. The fragment hypothesis — that…
Why plausible mechanism is not evidence of effect Replied, post #7 · Compounds › Repair & healing peptides · 27 Apr 2025 · 0 likes post #6 is right about the mechanism and I think understates the practical bit. Oral versus injected administration claims for BPC-157: the preclinical work studied…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #84 · Practice › Reconstitution · 20 Apr 2025 · 2 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Why a pen's dose steps are fixed and what that costs you — one year on Replied, post #9 · Devices › Pens & autoinjectors · 13 Apr 2025 · 2 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
What the published dose-response for semaglutide actually looks like above 2.4 mg — a… Replied, post #119 · Compounds › Semaglutide · 27 Mar 2025 · 17 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Coverage for the indication versus for the drug Replied, post #4 · Access › Insurance & coverage · 18 Mar 2025 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Triple agonism: additive, synergistic, or neither? Replied, post #27 · Compounds › Retatrutide · 16 Mar 2025 · 15 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Preparing for an appointment: one page, three questions Replied, post #11 · Clinical › Prescriber conversations · 16 Mar 2025 · 8 likes I read post #9 twice before replying, because I had assumed the opposite. Prescription logistics: confirm whether it will be filled locally, requires mail order, or…
A ten-fold dose error caught before injection Replied, post #7 · Devices › Syringes & needles · 8 Mar 2025 · 1 like On post #3 — agreed on the reasoning, with one qualification. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly…
Review: a draft on reconstitution arithmetic, with objections Replied, post #48 · Documentation › Doc review · 7 Mar 2025 · 3 likes Multilingual versions: if a maintained page should exist in another language, suggesting it here with your willingness to help translate can make it happen.
Pharmaceutical compounding rules, summarised from primary sources Replied, post #97 · Sourcing › Regulatory · 3 Mar 2025 · 14 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Pharmaceutical compounding rules, summarised from primary sources Replied, post #72 · Sourcing › Regulatory · 2 Mar 2025 · 0 likes Worth separating two things that post #68 runs together. Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #11 · Evidence › Meta-analyses · 26 Jan 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Why mass spectrometry cannot tell you about an epimer Replied, post #27 · Analytics › Mass spectrometry · 14 Jan 2025 · 5 likes What mass accuracy establishes: the measured mass is consistent with a specific composition. What it does not establish: purity, sequence order, stereochemistry, or the…
What we do not know about retatrutide, listed explicitly Replied, post #52 · Compounds › Retatrutide · 11 Jan 2025 · 0 likes I read post #50 twice before replying, because I had assumed the opposite. TRIUMPH is phase 3 and it is ongoing. No phase 3 results exist. Nothing should be attributed…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #60 · Compounds › Semaglutide · 10 Dec 2024 · 13 likes This follows post #57 rather than contradicting it. For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add…
Second pass at: Choosing a concentration on purpose rather than by accident Replied, post #40 · Practice › Reconstitution · 8 Dec 2024 · 22 likes A vial that will not fully dissolve: check in order: is the diluent genuinely room temperature (some preservatives crystallise in cold), is the vial being warmed gently…
Tracking semaglutide's approved indications across jurisdictions, dated — does this… Replied, post #56 · Compounds › Semaglutide · 2 Dec 2024 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #84 · Analytics › Method validation · 30 Nov 2024 · 0 likes post #83 is right about the mechanism and I think understates the practical bit. Range: the concentration range over which the method has been validated. Going outside…
Requesting a page: what makes a good request — what changed since Replied, post #105 · Documentation › Wiki requests · 12 Oct 2024 · 0 likes On post #101 — agreed on the reasoning, with one qualification. Request a new maintained page: if a question recurs, has a good marked solution, and contains a worked…
Second pass at: Hoarding and why it makes a shortage worse Replied, post #87 · Access › Shortages · 12 Oct 2024 · 0 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
When to suspect the method rather than the sample Replied, post #20 · Analytics › Method validation · 6 Oct 2024 · 8 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
Two sessions a week versus four: what the evidence supports — a second dataset Replied, post #30 · Nutrition & Training › Resistance training · 11 Jul 2024 · 3 likes This follows post #27 rather than contradicting it. Recovery: heavier training on a energy deficit and on a compound that slows gastric emptying requires attention to…
Tracking a preprint to publication: a worked example — the long version Replied, post #2 · Evidence › Preprints · 20 May 2024 · 3 likes On the opening post — agreed on the reasoning, with one qualification. Check whether it was later published: searching for the preprint's first author and keywords in…