p.krastev

TL2 Moderator · Lyon

Contributes reviews on supplier material. Based in Lyon.

Joined 6 April 2025 · last posted 8d

104 posts, newest first. Showing up to 150.

How shortages have affected compounding permissions Replied, post #55 · Access › Shortages · 20 Jul 2026 · 6 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
Immortal time bias in a claims-database study — one year on Replied, post #33 · Evidence › Study critique · 20 Jul 2026 · 21 likes I read post #31 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Deletion sequences: expected mass shifts by residue — the long version Replied, post #17 · Analytics › Impurities & related substances · 20 Jul 2026 · 10 likes Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A species that does not come off the column does not appear in…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #70 · Evidence › Journal club · 19 Jul 2026 · 30 likes PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy. Non-inferiority for safety was met. The trial was not designed to…
[2026 update] Journal club: what we got wrong in an earlier session Replied, post #6 · Evidence › Journal club · 10 Jul 2026 · 12 likes Picking up post #3: that is the part I would want checked first. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence…
Revisiting: What pooling buys you and what it destroys Replied, post #53 · Evidence › Meta-analyses · 13 Jun 2026 · 6 likes Why forest plots are more informative than pooled numbers: they show the variation across studies, which tells you whether the effect is consistent or heterogeneous. A…
GLP-1 receptor distribution: central and peripheral Replied, post #61 · Pharmacology › Receptor biology · 2 Jun 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Historical amylin analogues and what happened to them Replied, post #14 · Compounds › Cagrilintide & amylin analogues · 1 Jun 2026 · 0 likes What is genuinely unknown about long-term amylin agonism: real-world response rates, whether effect is durable with continued use, whether satiety adaptation occurs…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #34 · Analytics › HPLC & UHPLC · 29 May 2026 · 19 likes I read post #32 twice before replying, because I had assumed the opposite. Reversed-phase separates on hydrophobicity. A peptide is retained on a non-polar stationary…
Tracking intake honestly when appetite is absent Replied, post #40 · Nutrition & Training › Protein & intake · 28 May 2026 · 0 likes This follows post #37 rather than contradicting it. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #29 · Analytics › Home & field testing · 24 May 2026 · 32 likes post #28 is right about the mechanism and I think understates the practical bit. Enzyme assays: if you have an enzyme that reacts specifically with your compound, an…
An 18-month record including the parts that went badly Replied, post #19 · Outcomes › Progress reports · 18 May 2026 · 0 likes Menstrual cycle: for people who menstruate, weight can shift by several pounds across the cycle due to fluid retention and other factors. Noting cycle phase when…
Spreadsheets: an appreciation — what changed since Replied, post #45 · Lounge › Off topic · 17 May 2026 · 23 likes On post #41 — agreed on the reasoning, with one qualification. Science communication: if you come across an interesting science paper or article about peptides or…
The most useful thing you learned here that was not the answer you came for Replied, post #40 · Lounge › Off topic · 6 May 2026 · 1 like Newer drugs and mechanisms: when a new drug launches or a new mechanism is discovered, the Lounge is a place to discuss the news and speculate before hard data exists.
Revisiting: A field-by-field walk through a certificate of analysis Replied, post #5 · Analytics › COA interpretation · 28 Apr 2026 · 3 likes Worth separating two things that the opening post runs together. A certificate of analysis is a statement by its issuer that a defined test was performed on a defined…
Revisiting: Liver enzymes drifting down and what that usually means Replied, post #24 · Clinical › Bloodwork · 22 Apr 2026 · 11 likes Coming back to post #22, because the follow-up matters more than the original answer. Reference intervals: constructed to contain the central 95% of a reference…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #18 · Devices › Syringes & needles · 18 Apr 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
A widely repeated interaction claim that turns out to be unsupported Replied, post #43 · Practice › Interactions · 6 Apr 2026 · 0 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
Why the titration planner refuses to produce a schedule below a floor Replied, post #56 · Data & Tools › Calculators · 1 Apr 2026 · 10 likes post #55 is right about the mechanism and I think understates the practical bit. Precision and significant figures: the calculators do not round to match your input…
Grapefruit: why this class is not the class that cares Replied, post #90 · Practice › Interactions · 28 Mar 2026 · 13 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
Pinch or no pinch, and how needle length changes the answer — the long version Replied, post #35 · Practice › Administration · 24 Mar 2026 · 8 likes Coming back to post #33, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
Trust level 3 requirements: a clarification — does this still hold? Replied, post #17 · Meta › Announcements · 16 Mar 2026 · 10 likes Coming back to post #15, because the follow-up matters more than the original answer. Staff announcements, policy changes, and scheduled maintenance. Read-only except…
Reading a preclinical wound-healing model and its relevance to a human tendon — a second… Replied, post #13 · Compounds › Repair & healing peptides · 8 Mar 2026 · 2 likes post #12 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
Coming back to: Time to steady state after a dose increase Replied, post #9 · Pharmacology › Pharmacokinetics · 4 Mar 2026 · 1 like Worth separating two things that post #5 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Measurement error in a self-reported exposure Replied, post #70 · Evidence › Study critique · 25 Feb 2026 · 16 likes Coming back to post #68, because the follow-up matters more than the original answer. What makes a methodological criticism substantive: it identifies a specific…
Choosing which test to pay for, given a fixed budget Replied, post #5 · Sourcing › Independent verification · 24 Feb 2026 · 0 likes Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #16 · Compounds › Cagrilintide & amylin analogues · 20 Feb 2026 · 0 likes On post #12 — agreed on the reasoning, with one qualification. Is synergy the right word for the combination data? A phase 2 trial cannot establish whether effects are…
Follow-up: Evidence quality in the secretagogue literature: an honest assessment Replied, post #14 · Compounds › Secretagogues & GH axis · 16 Feb 2026 · 27 likes Evidence quality in the secretagogue literature is honestly weaker than in the incretin literature. Large randomised controlled trials are rare. Most evidence is…
Coming back to: Pen dose counters: what a click does and does not guarantee Replied, post #5 · Devices › Pens & autoinjectors · 11 Feb 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
The most common factual error about semaglutide on the internet — what changed since Replied, post #22 · Compounds › Semaglutide · 7 Feb 2026 · 16 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Guidelines revision: what changed and why — one year on Replied, post #67 · Meta › Announcements · 6 Feb 2026 · 11 likes Scheduled maintenance: if the site is going offline for maintenance, advance notice will be posted here with the duration and scope.
Gastro-oesophageal reflux: improving or worsening? Replied, post #16 · Clinical › Comorbidities · 3 Feb 2026 · 0 likes Cardiovascular disease: several compounds have cardiovascular outcome trials. SELECT was in people without diabetes; SUSTAIN 6 was in high-risk diabetes. Absolute…
Trifluoroacetate content and its consequences Replied, post #41 · Analytics › Impurities & related substances · 29 Jan 2026 · 17 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
Revisiting: Absolute versus relative contraindications Replied, post #15 · Safety › Contraindications · 28 Jan 2026 · 17 likes Picking up post #12: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
What a stability-indicating method is and how you demonstrate one Replied, post #3 · Analytics › Method validation · 13 Jan 2026 · 5 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
Follow-up: Search filters: what is missing Replied, post #12 · Meta › Site feedback · 10 Jan 2026 · 0 likes Accessibility: screen readers, keyboard navigation, contrast, font size — if something is not accessible to you, report it. Accessibility matters.
Ultrasound and skinfolds: operator dependence in practice — what changed since Replied, post #6 · Outcomes › Body composition · 8 Jan 2026 · 0 likes On post #2 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
AOD-9604 and the fragment hypothesis, revisited Replied, post #39 · Compounds › Other compounds · 31 Dec 2025 · 31 likes Compounds this community declines to help with, and why: there are specifics in the guidelines and they are not arbitrary. They exist because of failure modes that have…
Early satiety becoming a problem rather than a benefit Replied, post #19 · Practice › Side effects · 25 Dec 2025 · 0 likes This follows post #16 rather than contradicting it. Timeline matters: onset, duration, pattern over days or weeks, relationship to injection and to meals all provide…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #26 · Research Methods › N-of-1 designs · 10 Dec 2025 · 29 likes This follows post #23 rather than contradicting it. Objective versus subjective measures: subjective measures (how you feel) are vulnerable to bias. Objective measures…
Pen dose counters: what a click does and does not guarantee Replied, post #96 · Devices › Pens & autoinjectors · 19 Nov 2025 · 0 likes Reusability: some pens are single-use (throw away after one injection). Others can be reused until empty. Confirm which type you have. Reusing a single-use pen is…
Pen mechanics when the cartridge is nearly empty — does this still hold? Replied, post #15 · Devices › Pens & autoinjectors · 10 Nov 2025 · 0 likes Injection duration: most pens deliver the dose over several seconds. Holding the button down for the full duration ensures complete delivery. Releasing early can result…
Titles that describe the question, not the situation Replied, post #142 · Start Here › How to Ask · 6 Nov 2025 · 5 likes Coming back to post #140, because the follow-up matters more than the original answer. Disagreement-style questions: "I read this and it contradicts what I heard here,…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #41 · Compounds › Tirzepatide · 20 Oct 2025 · 2 likes SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were randomised to continue or placebo. Continuation maintained effect;…
Sleep tracking data and its considerable limitations Replied, post #36 · Wellbeing › Sleep · 19 Oct 2025 · 1 like Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #9 · Research Methods › N-of-1 designs · 2 Oct 2025 · 24 likes Coming back to post #7, because the follow-up matters more than the original answer. Statistical analysis of n-of-1 data: comparing before versus after with a t-test or…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #105 · Compounds › Oral incretins · 20 Sep 2025 · 13 likes Coming back to post #103, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first…
Temperature loggers worth the money Replied, post #30 · Devices › Cold chain · 15 Sep 2025 · 21 likes Light protection: avoid direct sunlight and UV exposure. Amber vials or opaque containers reduce light exposure. For short-term storage, keeping the vial in its…
Payment method and the leverage it gives you, ranked Replied, post #5 · marked as the solution · Sourcing › Payments · 13 Sep 2025 · 7 likes Documentation and tax implications: payments you make for compounds might have implications for tax reporting depending on your jurisdiction. Keeping clear records…
Aggregated purity results across four services, with caveats — a second dataset Replied, post #95 · Data & Tools › Datasets · 10 Sep 2025 · 4 likes Bias toward positive outcomes: datasets collected by members are biased toward people who found the compounds useful. People who did not respond do not return. People…
Aggregated purity results across four services, with caveats — a second dataset Replied, post #74 · Data & Tools › Datasets · 9 Sep 2025 · 24 likes I read post #72 twice before replying, because I had assumed the opposite. Community-collected datasets: some members have compiled datasets from their own experience…
How to research a compound with no human data without deceiving yourself Replied, post #95 · Compounds › Other compounds · 4 Aug 2025 · 0 likes Melanocortin agonists: mechanism involves the melanocortin-4 receptor pathway that regulates appetite. The documented adverse profile includes blood pressure elevation…
Second pass at: Reading a combination trial: attributing effect to components Replied, post #42 · Compounds › Cagrilintide & amylin analogues · 17 Jul 2025 · 0 likes The dosing interval: cagrilintide's half-life is roughly 7 to 8 days, suitable for weekly dosing. The pharmacokinetics are the reason the dosing schedule makes sense.
EU-wide position versus national implementation Replied, post #18 · Regional › European Union · 16 Jul 2025 · 8 likes Coming back to post #16, because the follow-up matters more than the original answer. Germany: BfArM implements EU framework. Statutory insurance (the majority)…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #87 · Wellbeing › Mental health · 11 Jul 2025 · 22 likes post #86 answers the question as asked. The question underneath it is different. Disordered eating history: a history of anorexia, bulimia, or other eating disorders…
Distinguishing a deletion sequence by mass alone — the long version Replied, post #32 · Analytics › Mass spectrometry · 8 Jul 2025 · 25 likes This follows post #29 rather than contradicting it. Purity and identity are different questions: LC-MS establishes that the species at a retention time has the expected…
Follow-up: The decimal-point error, and the habit that catches it Replied, post #22 · Practice › Reconstitution · 8 Jul 2025 · 2 likes A vial that will not fully dissolve: check in order: is the diluent genuinely room temperature (some preservatives crystallise in cold), is the vial being warmed gently…
A report I filed that turned out to be wrong, and the correction Replied, post #131 · Sourcing › Vendor reports · 1 Jul 2025 · 17 likes Lot matching: confirm the lot number on the certificate matches the lot number on the vial. A result from a different lot is not evidence about your vial.
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #124 · Clinical › Comorbidities · 25 Jun 2025 · 0 likes Obstructive sleep apnoea: SURMOUNT-OSA used an objective endpoint, the apnoea-hypopnoea index. Reduction was substantial. Whether the benefit is weight loss or a direct…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #144 · Practice › Reconstitution · 24 Jun 2025 · 33 likes Foaming during reconstitution: bubbles in the solution are usually just air incorporated during mixing. They usually resolve with gentle warming and time. Persistent…
Second pass at: Pharmacy supply in the UK and the questions you will be asked Replied, post #47 · Regional › UK & Ireland · 21 Jun 2025 · 14 likes Regional variation in NHS: access varies dramatically by region depending on local commissioning decisions and specialist service availability. Postcode determines…
Coming back to: When "no data" is the complete and final answer Replied, post #6 · Compounds › Other compounds · 5 Jun 2025 · 1 like When "no data" is the complete and final answer: if there is no published human data on a compound, that is the state of knowledge. Hope is not a substitute and…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #38 · Compounds › Oral incretins · 27 May 2025 · 0 likes post #37 answers the question as asked. The question underneath it is different. Orforglipron is a small molecule, not a peptide. That changes almost everything: no…
Half-life, steady state, and accumulation worked through Replied, post #16 · Pharmacology › Pharmacokinetics · 23 May 2025 · 11 likes SNAC (the oral bioavailability enhancer): sodium N-(8-[2-hydroxybenzoyl]amino) caprylate transiently raises gastric pH and promotes absorption. Without it, oral…
Reading a trial's population section before its results — does this still hold? Replied, post #133 · Evidence › Trials · 22 May 2025 · 1 like Multiplicity and multiple comparisons: if a trial tests many hypotheses, the chance of a false positive on at least one by random chance increases. This is why…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #109 · Compounds › Semaglutide · 8 May 2025 · 14 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Antibiotics and a course of something with delayed emptying Replied, post #33 · Practice › Interactions · 3 May 2025 · 0 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…
Adjudicated events and why the definition matters — the long version Replied, post #120 · Evidence › Trials · 26 Apr 2025 · 32 likes Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
Reading an MS report that only gives you a single number Replied, post #55 · Analytics › Mass spectrometry · 17 Apr 2025 · 17 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Requesting a page: what makes a good request Replied, post #51 · Documentation › Wiki requests · 9 Apr 2025 · 16 likes Authority and authorship: if you think a maintained page needs input from someone with specific expertise (a clinician, an analytical chemist) suggest who might…
UK access routes, dated and sourced — a second dataset Replied, post #57 · Regional › UK & Ireland · 30 Mar 2025 · 0 likes Private prescribing is legal and widespread, including through remote consultation. Pharmacies must satisfy themselves that a prescription is clinically appropriate.…
Second pass at: Cross-border purchase within the EU: the actual rules Replied, post #129 · Access › International · 28 Mar 2025 · 16 likes I read post #127 twice before replying, because I had assumed the opposite. Regulatory position dates: a regulatory position is only current as of when it was written.…
Documenting a supplier's response to a discrepancy — does this still hold? Replied, post #13 · Sourcing › Vendor reports · 22 Mar 2025 · 5 likes Blind submission is worth the effort: have someone else relabel the sample so neither you nor the laboratory knows which supplier it came from until the result is back.…
Adducts: sodium, potassium, and the peak you did not expect Replied, post #41 · Analytics › Mass spectrometry · 21 Mar 2025 · 14 likes Coming back to post #39, because the follow-up matters more than the original answer. Sample matrix effects: if a sample is dissolved in a complex matrix, other…
Maintainer handover: how it works Replied, post #54 · Meta › Wiki maintenance · 17 Mar 2025 · 17 likes Outdated external links: if a maintained page links to external sources and those links are broken or pages have moved, reporting that helps keep the page current.
Journal club: SURMOUNT-1, read without the press release Replied, post #72 · Evidence › Journal club · 6 Mar 2025 · 0 likes SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial in people without diabetes, which decoupled the cardiovascular…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #131 · Sourcing › Regulatory · 5 Mar 2025 · 1 like Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
A promotion I argued against, and why I lost Replied, post #110 · Documentation › Doc review · 24 Feb 2025 · 32 likes post #109 is right about the mechanism and I think understates the practical bit. Revision disputes: if you disagree with an edit a maintainer made to a page, discuss…
A certificate whose chromatogram axes do not match its stated method Replied, post #5 · Sourcing › Red flags · 22 Feb 2025 · 3 likes Rapid supplier turnover: a supplier that changes corporate structure, domain name, or contact repeatedly in short time windows raises suspicion about stability and…
Anaesthesia and elective surgery: the aspiration question — does this still hold? Replied, post #24 · Practice › Interactions · 18 Feb 2025 · 2 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
What we do not know about retatrutide, listed explicitly Replied, post #85 · Compounds › Retatrutide · 6 Feb 2025 · 2 likes Worth separating two things that post #81 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Protein density versus volume when you cannot eat much Replied, post #41 · Nutrition & Training › Protein & intake · 30 Jan 2025 · 0 likes Eating anything at all: on substantial appetite suppression, eating enough total calories to maintain lean mass is the priority. Protein comes second to total intake.
Canadian access and provincial variation Replied, post #14 · Regional › North America · 23 Jan 2025 · 0 likes Prior authorisation, step therapy, and exclusion of weight-management indications from coverage are common access barriers. The denial letter tells you which barrier…
Identical chromatograms across two different lots Replied, post #80 · Sourcing › Red flags · 22 Jan 2025 · 6 likes Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is showing you something about how they operate.
HbA1c lag and what it can and cannot tell you at eight weeks Replied, post #3 · Clinical › Bloodwork · 19 Jan 2025 · 7 likes HbA1c and glucose: HbA1c reflects average glucose over months; a spot glucose measurement reflects the moment. Trending glucose downward while HbA1c stays flat is a…
Recovery when intake is low: what to cut first Replied, post #67 · Nutrition & Training › Resistance training · 13 Jan 2025 · 25 likes Maintenance is the goal: preserving lean mass and strength during weight loss is the goal of resistance training in this context, not building new muscle. That goal is…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #79 · Compounds › Semaglutide · 23 Dec 2024 · 0 likes The mass figure differs between sources because of how the different entities report it. The monoisotopic mass of the bare peptide is one number; the mass including the…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #159 · Analytics › COA interpretation · 21 Dec 2024 · 2 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Coming back to: When to suspect the method rather than the sample Replied, post #103 · Analytics › Method validation · 20 Dec 2024 · 6 likes This follows post #100 rather than contradicting it. Range: the concentration range over which the method has been validated. Going outside the validated range is going…
Injection-site reactions: describing them precisely enough to be useful Replied, post #33 · Practice › Side effects · 29 Nov 2024 · 0 likes post #32 answers the question as asked. The question underneath it is different. Delayed gastric emptying: the mechanism behind much of the gastrointestinal side-effect…
SURPASS-2 and the comparator dose question that will not go away Replied, post #65 · Compounds › Tirzepatide · 26 Nov 2024 · 0 likes SURMOUNT-OSA is notable because it used an objective physiological endpoint, the apnoea-hypopnoea index, rather than a symptom scale. Two parallel trials, with and…
Fixed versus detachable needles: the trade-offs Replied, post #17 · Devices › Syringes & needles · 24 Nov 2024 · 0 likes Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #11 · Clinical › Special populations · 19 Nov 2024 · 7 likes Picking up post #8: that is the part I would want checked first. Disordered eating history: a history of anorexia nervosa, bulimia, or other eating disorders changes…
Time to steady state after a dose increase Replied, post #136 · Pharmacology › Pharmacokinetics · 6 Nov 2024 · 33 likes Coming back to post #134, because the follow-up matters more than the original answer. Renal clearance: these compounds are cleared partly via the kidney. In severe…
Revisiting: Holding a dose indefinitely: is there a documented downside? Replied, post #4 · Practice › Dosing & titration · 29 Oct 2024 · 0 likes post #3 is right about the mechanism and I think understates the practical bit. Dose equivalence between different incretin analogues is a weak concept. The molecules…
Coming back to: Research-use-only labelling: what it means and what it does not Replied, post #12 · Sourcing › Regulatory · 23 Oct 2024 · 0 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #69 · Clinical › Comorbidities · 20 Oct 2024 · 0 likes Picking up post #66: that is the part I would want checked first. Obstructive sleep apnoea: SURMOUNT-OSA used an objective endpoint, the apnoea-hypopnoea index.…
Food noise reducing and the disorientation that can follow Replied, post #14 · Wellbeing › Mental health · 29 Sep 2024 · 6 likes Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse.…
Reading a supplementary appendix and finding the interesting part Started this topic · Evidence › Trials · 29 Sep 2024 · 52 likes Reading a supplementary appendix and finding the interesting part — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med…
Gallbladder disease risk with rapid weight loss Replied, post #12 · Clinical › Comorbidities · 23 Sep 2024 · 1 like PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data on compounds in this class in PCOS specifically is…
Reporting a discrepancy without making an allegation Replied, post #43 · Sourcing › Vendor reports · 26 Aug 2024 · 29 likes Date the report: when the analysis was done matters. Material can degrade in storage. A report from two years ago is still useful but is not evidence about the current…
Coming back to: What consumer-accessible tests can and cannot determine Started this topic · Analytics › Home & field testing · 18 Aug 2024 · 28 likes Asking directly, because I could not find a straight answer: What consumer-accessible tests can and cannot determine Posting the method first, because I know what the…
How this community labels and discusses unrefereed work Replied, post #98 · Evidence › Preprints · 20 Jul 2024 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Second pass at: Journal club: LEADER as the historical anchor Replied, post #10 · Evidence › Journal club · 8 Jul 2024 · 4 likes Worth separating two things that post #6 runs together. FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped…