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414 topics · page 12 of 14

Topic	Participants	Replies	Views	Activity
Osteoarthritis and mechanical versus metabolic improvement — one year on Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea blood pressure Under review On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…	+52	56	8.1k	15d
[2026 update] Does a peptide degrade silently, with no visual change? Practice › Storage & stability temperature excursion storage freeze-thaw cold chain Does a peptide degrade silently, with no visual change? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a gap,…	+82	86	24k	15d
Racemisation and why it is invisible to a mass measurement — what changed since Analytics › Impurities & related substances forced degradation water content counter-ion content Racemisation and why it is invisible to a mass measurement — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I…	+11	15	42k	16d
[2026 update] Area percent versus weight percent: the confusion that causes most arguments Analytics › HPLC & UHPLC gradient method UV & DAD detection peak integration data table On the subject in the title: Area percent versus weight percent: the confusion that causes most arguments Working notes rather than a conclusion. Posting the method first, because I know what the first three…	+65	70	1.1k	16d
Interim analyses and stopping rules Evidence › Trials intention to treat surrogate endpoints open label discontinuation & dropout Interim analyses and stopping rules Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not think…	+25	29	35k	16d
Secretagogues and glucose tolerance: the mechanistic concern Compounds › Secretagogues & GH axis CJC-1295 tesamorelin observational data needs a source On the subject in the title: Secretagogues and glucose tolerance: the mechanistic concern Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+64	70	52k	17d
About the Resistance training category Nutrition & Training › Resistance training lean mass loss fatigue DXA Pinned Wiki Programming while losing weight quickly, realistic expectations, and recovery. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…		4	40k	17d
How much context is too much context in a first post? Start Here › How to Ask guidelines beginner friendly onboarding site feedback Solved How much context is too much context in a first post? I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+70	74	935	18d
Electrolyte supplements: which ones do anything Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Solved On the subject in the title: Electrolyte supplements: which ones do anything Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this that almost nobody writes about. I…	+47	51	31k	18d
Second pass at: Metformin co-administration and additive GI effects Practice › Interactions hypoglycaemia delayed gastric emptying metformin needs a source On the subject in the title: Second pass at: Metformin co-administration and additive GI effects Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+131	142	56k	19d
Second pass at: The storage lookup and where its data comes from Data & Tools › Calculators concentration maths syringe units site feedback worked example On the subject in the title: Second pass at: The storage lookup and where its data comes from Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…	+38	42	13k	19d
About the Oral incretins category Compounds › Oral incretins oral semaglutide orforglipron PIONEER programme Pinned Wiki Oral semaglutide, orforglipron and the absorption problem. PIONEER and OASIS data. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	6.2k	20d
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
Prescription requirements and telehealth models — a second dataset Sourcing › Regulatory compounding EMA MHRA personal import On the subject in the title: Prescription requirements and telehealth models — a second dataset Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+87	94	1.1k	21d
Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data tesamorelin needs a source GHRP class Wiki Asking directly, because I could not find a straight answer: Why this subcategory is stricter about sourcing than most Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+48	52	617	21d
Constipation management, with a dietitian's contribution Practice › Side effects constipation nausea delayed gastric emptying vomiting Solved Posting this under the heading it deserves: Constipation management, with a dietitian's contribution Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+79	88	27k	21d
Second pass at: Cagrilintide molecular characteristics and analytical considerations Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrisema On the subject in the title: Second pass at: Cagrilintide molecular characteristics and analytical considerations Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019).…		4	5k	21d
Naming conventions for research peptides and the confusion they cause Compounds › Other compounds custom synthesis mislabelling research use only needs a source Posting this under the heading it deserves: Naming conventions for research peptides and the confusion they cause Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+21	25	4.9k	22d
Carryover and the ghost peak from last week's standard — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC UV & DAD detection Solved Carryover and the ghost peak from last week's standard — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the…	+98	114	37k	22d
What to include when your question involves a laboratory result — a second dataset Start Here › How to Ask onboarding guidelines worked example site feedback Solved What to include when your question involves a laboratory result — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context…		2	7k	23d
Coming back to: A newcomer's list of things that confused me, and the fixes Start Here › Welcome guidelines onboarding trust levels beginner friendly Posting this under the heading it deserves: A newcomer's list of things that confused me, and the fixes Everything below is what sits behind that. Question in the title. Context below, and I have tried to…	+4	8	57k	23d
Bioimpedance and hydration: why the number moves Outcomes › Body composition lean mass loss data table DXA bioimpedance Bioimpedance and hydration: why the number moves — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a method is not a…	+62	70	13k	23d
Sample size intuition for a personal experiment — does this still hold? Research Methods › Statistics effect size heterogeneity number needed to treat Solved Sample size intuition for a personal experiment — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021) with…	+33	38	26k	23d
Why fasting instructions for oral semaglutide are not optional advice Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Solved Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016)…	+70	74	1.1k	23d
Follow-up: Interpreting a composition change that is within the error bars Outcomes › Body composition DXA lean mass loss bioimpedance data table Solved Interpreting a composition change that is within the error bars Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a number…		2	95	24d
Deamidation and the close-eluting pair it produces — the long version Analytics › Impurities & related substances counter-ion content endotoxin testing data table Posting this under the heading it deserves: Deamidation and the close-eluting pair it produces — the long version Everything below is what sits behind that. I would like to understand what this number means…		3	347	24d
Why oral semaglutide needs an absorption enhancer at all — one year on Compounds › Oral incretins randomised trial SOUL trial oral semaglutide PIONEER programme Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited…	+11	15	17k	24d
Personal or family history of medullary thyroid carcinoma — what changed since Safety › Contraindications pancreatitis thyroid C-cell question delayed gastric emptying Posting this under the heading it deserves: Personal or family history of medullary thyroid carcinoma — what changed since Everything below is what sits behind that. Asking about a population rather than…	+91	96	1.3k	25d
Purity assay versus content assay: two different numbers Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Purity assay versus content assay: two different numbers Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+6	10	24k	25d
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Compounds › Oral incretins randomised trial oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022)…	+27	31	17k	25d