Latest topics page 51

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 51 of 52

Topic	Participants	Replies	Views	Activity
Cold packs, phase-change material, and what survives ten days — does this still hold? Sourcing › Logistics packaging temperature excursion customs shipping Asking directly, because I could not find a straight answer: Cold packs, phase-change material, and what survives ten days — does this still hold? A logistics question, since the answers here are usually…		2	22k	22mo
Hoarding and why it makes a shortage worse Access › Shortages formulary shortage compounding FDA Posting this under the heading it deserves: Hoarding and why it makes a shortage worse Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this category…		2	12k	22mo
Revisiting: US compounding rules and how they changed Regional › North America insurance telehealth compounding On the subject in the title: Revisiting: US compounding rules and how they changed Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+5	9	26k	23mo
How to ask for a dose change without antagonising anyone Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Solved The question in the title: How to ask for a dose change without antagonising anyone I will give what I have already checked below so nobody repeats it. Asking about a population rather than about a person.…	+19	23	2.9k	23mo
[2026 update] People with a low starting BMI: where the evidence stops Clinical › Special populations chronic kidney disease adolescents pregnancy & planning bariatric surgery history People with a low starting BMI: where the evidence stops Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+19	23	62k	23mo
A rising related-substance total over six months: degradation or method drift? Analytics › Impurities & related substances data table endotoxin testing HPLC Closed Asking directly, because I could not find a straight answer: A rising related-substance total over six months: degradation or method drift? Posting the method first, because I know what the first three…	+37	42	37k	23mo
Orforglipron as a non-peptide: what changes when the molecule is small Compounds › Oral incretins orforglipron SOUL trial PIONEER programme On the subject in the title: Orforglipron as a non-peptide: what changes when the molecule is small Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURMOUNT-4 ( JAMA ,…	+26	30	26k	23mo
Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Posting this under the heading it deserves: Reading a meta-analysis you disagree with, fairly Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+7	13	2.5k	23mo
Circumference measurements as a poor man's composition estimate Outcomes › Body composition bioimpedance data table DXA lean mass loss Solved Posting this under the heading it deserves: Circumference measurements as a poor man's composition estimate Everything below is what sits behind that. Longitudinal report with the method stated, because a…	+96	112	14k	23mo
Correlation in a self-tracked dataset: what it can support Research Methods › Statistics effect size heterogeneity worked example number needed to treat Closed Correlation in a self-tracked dataset: what it can support — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not think it…	+152	166	48k	23mo
Follow-up: A partial dose because the pen emptied mid-injection Practice › Administration injection site reaction subcutaneous injection injection site rotation aseptic technique Posting this under the heading it deserves: A partial dose because the pen emptied mid-injection Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I…	+10	14	10k	23mo
Chronic kidney disease and the FLOW result Clinical › Comorbidities PCOS blood pressure chronic kidney disease MASH / hepatic steatosis Solved Posting this under the heading it deserves: Chronic kidney disease and the FLOW result Everything below is what sits behind that. General question, not a request for advice about my own care — I know the…	+34	38	33k	23mo
High-resolution MS on aggregates and what it can see — one year on Analytics › Mass spectrometry LC-MS counter-ion content MALDI-TOF charge states Solved High-resolution MS on aggregates and what it can see — one year on Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like…	+54	58	1.2k	23mo
Coming back to: Purity assay versus content assay: two different numbers Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Under review Purity assay versus content assay: two different numbers — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…	+71	77	31k	23mo
The most common factual error about semaglutide on the internet Compounds › Semaglutide STEP programme randomised trial type 2 diabetes effect size On the subject in the title: The most common factual error about semaglutide on the internet Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the…		2	49k	2y
Coming back to: Pricing far outside the range, in either direction Sourcing › Red flags documentation quality underdosing mislabelling Pricing far outside the range, in either direction Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the format the…	+22	26	325	2y
Naming conventions for research peptides and the confusion they cause — one year on Compounds › Other compounds research use only mislabelling needs a source Naming conventions for research peptides and the confusion they cause — one year on — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in…	+1	5	181	2y
[2026 update] Request: show the solution author in the topic list Meta › Feature requests site feedback wiki post translation Request: show the solution author in the topic list Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The…		2	59	2y
Mean kinetic temperature explained without the mathematics Practice › Storage & stability temperature excursion freeze-thaw storage cloudy or discoloured solution Posting this under the heading it deserves: Mean kinetic temperature explained without the mathematics Everything below is what sits behind that. Practical question with the units stated, because I have seen…		2	1.5k	2y
The mass-error checker and its intended scope Data & Tools › Calculators worked example concentration maths syringe units site feedback The mass-error checker and its intended scope Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+149	167	42k	2y
Second pass at: Journal club: LEADER as the historical anchor Evidence › Journal club randomised trial journal club effect size estimand Posting this under the heading it deserves: Second pass at: Journal club: LEADER as the historical anchor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURPASS-2 ( N…	+75	81	2k	2y
Guidelines revision: what changed and why Meta › Announcements guidelines moderation trust levels Guidelines revision: what changed and why Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the guidelines and the…	+127	142	1.7k	2y
How this community labels and discusses unrefereed work Evidence › Preprints risk of bias effect size preprint needs a source How this community labels and discusses unrefereed work — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited in support of a…	+112	119	1.3k	2y
Follow-up: Conditions that change the calculus rather than forbidding it Safety › Contraindications pancreatitis disordered eating thyroid C-cell question pregnancy & planning Posting this under the heading it deserves: Conditions that change the calculus rather than forbidding it Everything below is what sits behind that. General question, not a request for advice about my own…	+30	34	62k	2y
Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration missed dose semaglutide tirzepatide titration Solved On the subject in the title: Where the four-week escalation interval comes from, and what it is not Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I…	+56	60	21k	2y
Refrigerated versus room temperature: the trade-off stated plainly Practice › Storage & stability cold chain cloudy or discoloured solution storage beyond-use date Refrigerated versus room temperature: the trade-off stated plainly Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have…		2	66k	2y
Second pass at: Retatrutide dose escalation in the published trials Compounds › Retatrutide retatrutide randomised trial preprint Under review Second pass at: Retatrutide dose escalation in the published trials — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim…	+115	125	30k	2y
Cold packs, phase-change material, and what survives ten days Sourcing › Logistics shipping temperature excursion cold chain customs Cold packs, phase-change material, and what survives ten days — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+132	138	65k	2y
Oral contraceptives and delayed emptying: what the data shows Practice › Interactions metformin delayed gastric emptying insulin Solved Posting this under the heading it deserves: Oral contraceptives and delayed emptying: what the data shows Everything below is what sits behind that. Reporting something rather than asking about it, in case…	+63	71	5.9k	2y
Journal club: FLOW and the renal composite, component by component Evidence › Journal club randomised trial estimand risk of bias On the subject in the title: Journal club: FLOW and the renal composite, component by component Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…	+84	91	18k	2y