Skip to content

Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public

Pharmacology · subcategory

Formulation chemistry

Buffers, pH, isotonicity, preservatives, lyophilisation and excipient function.

16 topics297 posts2 solved Moderators: hana.sato, bench_notes About this category

bacteriostatic water sterile water cloudy or discoloured solution storage counter-ion content

16 topics

Topic	Participants	Replies	Views	Activity
About the Formulation chemistry category bacteriostatic water sterile water cloudy or discoloured solution Pinned Wiki Buffers, pH, isotonicity, preservatives, lyophilisation and excipient function. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…		4	4.5k	18mo
Coming back to: Solubility limits and what a cloudy solution is telling you sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. Reading back through what has been written here about Solubility limits, three…	+38	43	29k	13h
Solubility limits and what a cloudy solution is telling you cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. The question about solubility limits that I actually want answered is the…	+11	15	34k	20h
Preservatives: function, testing, and limits — one year on sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…	+28	32	437	8d
Follow-up: Lyophilisation and why the cake looks the way it does bacteriostatic water cloudy or discoloured solution sterile water Solved Lyophilisation and why the cake looks the way it does Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about Lyophilisation in a thread last spring and I would…	+10	14	11k	3mo
[2026 update] Buffers, pH and why a formulation is a formulation counter-ion content storage bacteriostatic water cloudy or discoloured solution Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. A formulation question rather than a pharmacological one, though the…		2	773	3mo
Adsorption to container surfaces and to plastics cloudy or discoloured solution counter-ion content sterile water bacteriostatic water On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. I was wrong about adsorption in a thread last spring and I would like to correct it…	+13	17	4.3k	5mo
Lyophilisation and why the cake looks the way it does sterile water bacteriostatic water storage cloudy or discoloured solution Posting this under the heading it deserves: Lyophilisation and why the cake looks the way it does Everything below is what sits behind that. I was wrong about lyophilisation in a thread last spring and I…	+33	37	60k	6mo
Second pass at: Isotonicity and what happens when you get it wrong counter-ion content storage bacteriostatic water sterile water Closed Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Something about Isotonicity does not reconcile and I would like a…	+1	5	2.6k	11mo
Excipient function in a licensed injectable bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about excipient function in a thread last spring and I would like to…	+3	7	36k	14mo
Excipient function in a licensed injectable — the long version sterile water storage bacteriostatic water Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. A narrow question about Excipient function, deliberately…		2	100	15mo
Preservatives: function, testing, and limits counter-ion content storage bacteriostatic water sterile water Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. An honest uncertainty about preservatives rather than a disguised assertion. I do not know…	+23	27	3.7k	16mo
Coming back to: Adsorption to container surfaces and to plastics bacteriostatic water counter-ion content storage sterile water Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Adsorption — I have the observation and I do not trust my interpretation of it, so I am…		2	459	17mo
Isotonicity and what happens when you get it wrong sterile water counter-ion content storage On the subject in the title: Isotonicity and what happens when you get it wrong Working notes rather than a conclusion. I was wrong about isotonicity in a thread last spring and I would like to correct it…	+27	31	11k	18mo
Buffers, pH and why a formulation is a formulation counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. A formulation question rather than a pharmacological one, though the two…	+11	15	51k	21mo
Second pass at: Buffers, pH and why a formulation is a formulation counter-ion content cloudy or discoloured solution sterile water Wiki Second pass at: Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Buffers. It is mine, it is…	+24	28	1.5k	21mo

Sponsored Sigma-Aldrich — certified reference materialsReference standards, analytical reagents and certified materials for method calibration. If you are validating a method, this is where the standard comes from.Reference standards →