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Devices · Syringes & needles · continued

Follow-up: Dead volume across syringe and needle combinations posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

QZ
q.zhao_qaTL3Quality assurance6 Sep 2024#31

post #30 answers the question as asked. The question underneath it is different.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

18 likes 23mo
RL
r.lundgrenTL2 Moderator8 Sep 2024#32

On post #28 — agreed on the reasoning, with one qualification.

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

0 likes 23mo
DM
d.moreauTL2Regular11 Sep 2024 · edited#33

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

1 like 23mo
YI
y.ibarraTL213 Sep 2024#34
PE
ppm_errorTL3Analytical chemist15 Sep 2024#35
b.wikstrom, post #26: Picking up post #23: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use. Go to post

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

25 likes in reply to #26 22mo
AP
a.pereiraTL2 Moderator17 Sep 2024#36

Worth separating two things that post #32 runs together.

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

0 likes 22mo
FP
forest_plotTL3Evidence synthesis19 Sep 2024#37

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

4 likes 22mo
SA
s.antonsenTL2 Moderator21 Sep 2024#38

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

12 likes 22mo
HS
hana.satoTL4 Moderator23 Sep 2024#39
s.vukovic, post #3: Worth separating two things that the opening post runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

8 likes in reply to #3 22mo
CO
c.ostergaardTL2 Moderator25 Sep 2024#40

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

19 likes 22mo
OV
o.vogelTL2 Moderator28 Sep 2024#41
s.antonsen, post #38: Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive. Go to post

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

27 likes in reply to #38 22mo
MD
m.duarteTL2 Moderator30 Sep 2024#42
r.mensah, post #30: Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice. Go to post

post #41 answers the question as asked. The question underneath it is different.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

13 likes in reply to #30 22mo
DT
d.tammTL2 Moderator2 Oct 2024#43

Coming back to post #41, because the follow-up matters more than the original answer.

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

4 likes 22mo
AZ
a.zamoraTL2 Moderator4 Oct 2024#44

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

0 likes 22mo
AB
a.batistaTL2 Moderator6 Oct 2024#45

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

20 likes 22mo
AN
a.nwosuTL2 Moderator8 Oct 2024#46
p.diallo, post #28: Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses. Go to post

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

8 likes in reply to #28 22mo
BN
bench_notesTL4 Moderator10 Oct 2024 · edited#47

I read post #45 twice before replying, because I had assumed the opposite.

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

2 likes 22mo
KP
k.perrinTL2 Moderator12 Oct 2024#48

This follows post #45 rather than contradicting it.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes 22mo
MD
m.dumitruTL2 Moderator14 Oct 2024#49
a.pereira, post #36: Worth separating two things that post #32 runs together. Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

14 likes in reply to #36 21mo
DW
diluent_watchTL216 Oct 2024#50
TI
t.ibarraTL2 Moderator18 Oct 2024#51

Picking up post #48: that is the part I would want checked first.

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

0 likes 21mo
I
IsaksenTL3Regular20 Oct 2024#52

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

0 likes 21mo
NA
n.achebeTL2 Moderator22 Oct 2024#53

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

5 likes 21mo
TN
t.nardoneTL3Regular24 Oct 2024#54
glossary_desk, post #20: Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers. Go to post

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

14 likes in reply to #20 21mo
KK
k.kuuselaTL2 Moderator26 Oct 2024#55
s.antonsen, post #38: Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive. Go to post

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

29 likes in reply to #38 21mo
FE
footnote_entryTL3Regular28 Oct 2024#56

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

0 likes 21mo
RB
r.bakkenTL2 Moderator29 Oct 2024 · edited#57

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

2 likes 21mo
NR
n.rowntreeTL3Regular31 Oct 2024#58
bench_entry, post #27: Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Worth separating two things that post #54 runs together.

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

9 likes in reply to #27 21mo
RC
r.chukwuTL2 Moderator2 Nov 2024#59
bench_notes, post #47: I read post #45 twice before replying, because I had assumed the opposite. Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters. Go to post

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

21 likes in reply to #47 21mo
B
BramleyTL2Member4 Nov 2024#60

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

0 likes 21mo