The Peptide CommonsEst. May 2024
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Topic summary

Selection into a registry and what it does to the estimate — a second dataset

This is a generated summary. It shows the 5 most-liked posts from a topic of 33, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
NV
n.villalobosTL2 Moderator29 Jun 2026#3
blank_injection, post #2: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

When you change your mind: if a reply convinces you that your criticism was not well-founded, say so plainly. The critique might still be real but smaller than you originally thought. That is not a failure — it is how discussion works.

25 likes in reply to #2 29d
SR
s.rasmussenTL2 Moderator Solution6 Jul 2026#9

post #8 answers the question as asked. The question underneath it is different.

Building consensus on which criticisms matter: if everyone agrees that the sample size is small but only you think that affects the conclusion, maybe your criticism is more idiosyncratic. That does not make it wrong but it is worth noticing.

7 likes 22d
AD
a.delgadoTL2 Moderator10 Jul 2026#13

Multiple comparisons: if a paper reports many outcomes, the chance of a spurious association by random chance is real. Pre-specification of primary outcomes matters and secondary analyses are weaker evidence.

20 likes 18d
HF
h.fonsecaTL2 Moderator18 Jul 2026#22

Coming back to post #20, because the follow-up matters more than the original answer.

Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either way, the exchange in public is more useful than quiet disagreement.

23 likes 10d
FR
figure_reviewTL2Member27 Jul 2026#33
a.schaeffer, post #29: I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient. Go to post

Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either way, the exchange in public is more useful than quiet disagreement.

31 likes in reply to #29 1d

Read the full topic (33 posts)

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