Tags · Status
worked example
Contains arithmetic shown step by step.
Related in this group: solved · open question · needs a source · long read · beginner friendly · data table · disputed
139 topics · page 3 of 5
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An ABAB design with a data table and honest limitations — a second dataset
On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…
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+106 | 118 | 25k | 4mo |
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Measurement error in home scales, with a worked standard deviation
Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…
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+26 | 31 | 4.3k | 4mo |
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Rewriting my first post: a before-and-after, with commentary
Rewriting my first post: a before-and-after, with commentary Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather than get a conclusion. My…
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3 | 2.7k | 4mo | |
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About the Dosing & titration category
Schedules, escalation intervals, dose reductions, and the arithmetic that connects a vial to a syringe mark. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…
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4 | 350 | 4mo | |
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Splitting a weekly dose in two: the pharmacokinetic argument against
Splitting a weekly dose in two: the pharmacokinetic argument against — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I…
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+24 | 28 | 51k | 5mo |
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How the published trials escalated, tabulated side by side
The question in the title: How the published trials escalated, tabulated side by side I will give what I have already checked below so nobody repeats it. A question about technique rather than about dose. I…
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+4 | 8 | 4.2k | 5mo |
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Absence of evidence and evidence of absence
Absence of evidence and evidence of absence Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read it before…
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+16 | 20 | 3.9k | 5mo |
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The lowest dose that does anything: is that a real question?
Asking directly, because I could not find a straight answer: The lowest dose that does anything: is that a real question? I have read the maintained page on this and I still have a gap, so I am asking rather…
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+100 | 111 | 9.1k | 5mo |
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Dead volume across syringe and needle combinations
On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong…
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+72 | 80 | 28k | 5mo |
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An ABAB design with a data table and honest limitations
An ABAB design with a data table and honest limitations Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…
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2 | 45k | 5mo | |
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Why "dose equivalence" between different incretin analogues is a weak concept
Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…
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+124 | 133 | 11k | 5mo |
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About the Calculators category
Reconstitution, dose equivalence, titration planning, mass-error checking and storage lookup. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…
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+2 | 7 | 733 | 5mo |
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Designing a personal experiment that could change your mind
Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before…
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+2 | 6 | 695 | 6mo |
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What to include when your question involves a chromatogram
What to include when your question involves a chromatogram I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…
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+49 | 54 | 58k | 6mo |
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Why "add 2 mL" is not an instruction
The question in the title: Why "add 2 mL" is not an instruction I will give what I have already checked below so nobody repeats it. A question about technique rather than about dose. I have been doing the…
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+23 | 27 | 3.5k | 6mo |
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What to include when your question involves arithmetic
What to include when your question involves arithmetic — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…
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2 | 3.1k | 7mo | |
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Coming back to: Over-dilution: when your dose falls below one readable graduation
Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…
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+90 | 97 | 1.1k | 7mo |
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The decimal-point error, and the habit that catches it
The decimal-point error, and the habit that catches it Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…
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+110 | 121 | 10k | 7mo |
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Coming back to: Feature request: should a dose-equivalence tool exist at all?
Feature request: should a dose-equivalence tool exist at all? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…
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+37 | 41 | 725 | 7mo |
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Second pass at: Asking a follow-up: new topic or new reply?
The question in the title: Second pass at: Asking a follow-up: new topic or new reply? I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…
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4 | 81 | 8mo | |
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Gauge and length selection for subcutaneous injection
Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…
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+50 | 55 | 1.3k | 8mo |
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Second pass at: The mass-error checker and its intended scope
Posting this under the heading it deserves: Second pass at: The mass-error checker and its intended scope Everything below is what sits behind that. Working through the identity arithmetic and I would like it…
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+70 | 74 | 1.7k | 8mo |
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[2026 update] How much of the diluent volume the powder itself displaces
The question in the title: How much of the diluent volume the powder itself displaces I will give what I have already checked below so nobody repeats it. Practical question with the units stated, because I…
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+89 | 100 | 3.2k | 8mo |
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What a confidence interval means, from scratch — the long version
The question in the title: What a confidence interval means, from scratch — the long version I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet , 2023) cited…
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+16 | 20 | 2.3k | 8mo |
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A calculator that gives a right answer to the wrong question — does this still hold?
A calculator that gives a right answer to the wrong question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what…
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+23 | 27 | 62k | 8mo |
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Titles that describe the question, not the situation
Titles that describe the question, not the situation — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things people…
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+139 | 153 | 22k | 8mo |
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[2026 update] What steady state means for the decision to escalate
The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still have a…
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+127 | 137 | 32k | 8mo |
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Follow-up: The lowest dose that does anything: is that a real question?
The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…
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+70 | 75 | 12k | 8mo |
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Why "any advice?" is the least effective ending for a post — the long version
Asking directly, because I could not find a straight answer: Why "any advice?" is the least effective ending for a post — the long version Question in the title. Context below, and I have tried to include the…
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+79 | 83 | 1.6k | 9mo |
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A 10 mg vial reconstituted three different ways, compared — the long version
A 10 mg vial reconstituted three different ways, compared — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…
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+146 | 158 | 47k | 9mo |