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On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 3 of 14

Topic	Participants	Replies	Views	Activity
Follow-up: Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+62	67	12k	9h
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Analytics › Home & field testing third-party testing LOD & LOQ documentation quality ELISA Solved On the subject in the title: Lateral-flow and colorimetric approaches: the specificity problem Working notes rather than a conclusion. Lateral-flow and colorimetric approaches — I have the observation and I…	+77	89	16k	9h
Journal club: STEP 1 and the treatment-policy estimand Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: STEP 1 and the treatment-policy estimand Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…		3	11k	9h
Adolescents: a distinct evidence base Clinical › Special populations older adults pregnancy & planning adolescents chronic kidney disease Adolescents: a distinct evidence base Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of adolescents is wrong? I ask because I have been…		3	11k	9h
A 40-week log with the measurement method stated — what changed since Outcomes › Progress reports effect size data table DXA long read Solved A 40-week log with the measurement method stated — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on 40-week log. It is mine, it…	+9	13	2.1k	9h
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Two things I would like separated before anyone answers on Trust level 3…	+77	90	57k	9h
Deletion sequences: expected mass shifts by residue — the long version Analytics › Impurities & related substances water content endotoxin testing data table forced degradation On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Deletion sequences keeps being re-asked here and I think that is…	+21	25	6.9k	10h
Endotoxin and why it is a separate question from purity — what changed since Analytics › Impurities & related substances HPLC endotoxin testing data table forced degradation On the subject in the title: Endotoxin and why it is a separate question from purity — what changed since Working notes rather than a conclusion. What changes if the standard account of Endotoxin is wrong? I…	+78	91	1k	10h
What consumer-accessible tests can and cannot determine — a second dataset Analytics › Home & field testing ELISA LOD & LOQ third-party testing documentation quality Solved What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting a small dataset on…	+117	131	45k	10h
What a statistical analysis plan adds that the paper does not Evidence › Trials open label discontinuation & dropout randomised trial surrogate endpoints Solved What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. Statistical analysis plan, and specifically the version…		2	6.6k	10h
Second pass at: Reading a trial's population section before its results Evidence › Trials open label intention to treat estimand surrogate endpoints Solved Second pass at: Reading a trial's population section before its results Writing it up because I had to work it out twice and would rather nobody else did. Reading STEP 1 ( N Engl J Med , 2021) for the…		4	9.5k	10h
Follow-up: Prior authorisation: what the criteria usually require Access › Insurance & coverage insurance appeals formulary prior authorisation Solved Prior authorisation: what the criteria usually require — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about Prior authorisation.…	+95	100	9.1k	10h
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Posting a series rather than a conclusion, with the method first.…	+109	125	42k	10h
Second pass at: Sleep apnoea improving and the equipment implications Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea On the subject in the title: Second pass at: Sleep apnoea improving and the equipment implications Working notes rather than a conclusion. Asking about sleep specifically, and trying to keep it separate from…	+89	96	1.1k	10h
German, French and Dutch differences, compared Regional › European Union cost per milligram formulary EMA German, French and Dutch differences, compared — setting out what I have, and where I think it stops being reliable. Asking about german directly, because I have read four threads on it and each answered a…		2	12k	10h
Revisiting: Mobile reading experience on long topics Meta › Site feedback moderation guidelines site feedback Solved Posting this under the heading it deserves: Revisiting: Mobile reading experience on long topics Everything below is what sits behind that. Bringing the figures rather than the impression, since a process…	+11	15	34k	10h
Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Solved Why 99.2% and 97.8% on the same lot can both be correct I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+16	20	3.1k	11h
Cost versus information: making the trade-off explicitly Analytics › Home & field testing LOD & LOQ third-party testing ELISA documentation quality Cost versus information: making the trade-off explicitly Writing it up because I had to work it out twice and would rather nobody else did. Asking about cost versus information directly, because I have read…	+2	6	12k	11h
A comparison of home results against a laboratory result on the same vial — does this still hold? Analytics › Home & field testing ELISA third-party testing LOD & LOQ documentation quality Solved A comparison of home results against a laboratory result on the same vial — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparison of home…	+2	6	15k	11h
Primary endpoint hierarchies and why order matters — one year on Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial Solved On the subject in the title: Primary endpoint hierarchies and why order matters — one year on Working notes rather than a conclusion. A follow-up question about Primary endpoint hierarchies that I did not…	+56	61	37k	11h
Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork liver enzymes thyroid function lipid panel lipase & amylase Solved Posting this under the heading it deserves: Lipid changes during rapid weight loss: the expected trajectory Everything below is what sits behind that. Lipid changes during rapid weight: what I expected, what…	+11	15	34k	11h
Comparing my trajectory with the trial curves, carefully — a second dataset Outcomes › Progress reports effect size data table long read Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that…	+77	81	16k	11h
Follow-up: The most useful thing you learned here that was not the answer you came for Lounge › Off topic beginner friendly long read On the subject in the title: The most useful thing you learned here that was not the answer you came for Working notes rather than a conclusion. A digression I have been saving for the right category. It is…	+30	34	9.7k	11h
About the Comorbidities category Clinical › Comorbidities type 2 diabetes chronic kidney disease MASH / hepatic steatosis Pinned Wiki Type 2 diabetes, hepatic steatosis, sleep apnoea, cardiovascular and renal disease. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	16k	12h
Common supplements people ask about, assessed one at a time Practice › Interactions insulin needs a source hypoglycaemia metformin Common supplements people ask about, assessed one at a time — setting out what I have, and where I think it stops being reliable. A follow-up question about common supplements that I did not know to ask the…	+101	107	28k	12h
Reflectance and photometric devices: precision in practice — a second dataset Analytics › Home & field testing ELISA LOD & LOQ documentation quality Reflectance and photometric devices: precision in practice — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Reflectance and photometric…	+75	82	17k	12h
Osteoarthritis and mechanical versus metabolic improvement Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease type 2 diabetes obstructive sleep apnoea Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did. Asking about osteoarthritis and mechanical versus metabolic…	+2	6	30k	12h
Why the cheapest option is often not the cheapest Access › Pricing compounding formulary cost per milligram data table Solved Wiki Why the cheapest option is often not the cheapest I have a specific reason for asking rather than idle curiosity, and the context is below. Cheapest option: setting out the arithmetic in full, because I have…	+19	23	1.2k	12h
An 18-month record including the parts that went badly Outcomes › Progress reports data table long read effect size DXA An 18-month record including the parts that went badly — setting out what I have, and where I think it stops being reliable. Asking about 18-month record on behalf of the question I keep seeing asked badly,…	+77	81	17k	12h
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. A narrow question about headache, deliberately narrow, because the broad…	+68	73	1.3k	12h