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On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 4 of 14

Topic	Participants	Replies	Views	Activity
A promotion I argued against, and why I lost — a second dataset Documentation › Doc review citation check promoted to docs wiki post A promotion I argued against, and why I lost — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation…	+3	7	32k	12h
The anatomy of a question that gets answered within an hour Start Here › How to Ask worked example site feedback onboarding beginner friendly Wiki The anatomy of a question that gets answered within an hour — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things…	+113	127	2.7k	13h
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
[2026 update] Antibiotics and a course of something with delayed emptying Practice › Interactions metformin needs a source delayed gastric emptying insulin On the subject in the title: Antibiotics and a course of something with delayed emptying Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful…	+88	97	19k	13h
Shoulders, tangent skims, and defensible integration Analytics › HPLC & UHPLC peak integration UV & DAD detection HPLC gradient method Posting this under the heading it deserves: Shoulders, tangent skims, and defensible integration Everything below is what sits behind that. Posting the method first, because I know what the first three…	+16	20	11k	13h
Composite endpoints and the component doing the work Evidence › Trials randomised trial surrogate endpoints open label discontinuation & dropout Solved Under review Composite endpoints and the component doing the work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I do…	+3	7	33k	13h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med ,…	+18	22	656	13h
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Clinical › Bloodwork liver enzymes lipase & amylase lipid panel thyroid function Posting this under the heading it deserves: HbA1c lag and what it can and cannot tell you at eight weeks — one year on Everything below is what sits behind that. General question, not a request for advice…	+18	22	655	13h
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+121	126	35k	13h
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+38	43	29k	13h
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
Why side effects reset at each escalation and that is not a failure Practice › Side effects constipation nausea fatigue delayed gastric emptying Solved Why side effects reset at each escalation and that is not a failure — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still…	+3	7	11k	14h
Aggregate verification data across the directory, with caveats Sourcing › Independent verification Medutest blind sampling PeptideMeter Under review On the subject in the title: Aggregate verification data across the directory, with caveats Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+64	74	4.6k	14h
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Asking about a population rather than about a person. The published trials…	+20	24	855	14h
Follow-up: Sleep quality changes during weight loss Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I would…	+74	80	4.4k	14h
Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import cost per milligram MHRA Pinned On the subject in the title: Private prescribing in the UK: what is actually involved Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+66	76	46k	14h
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h
Why pulsatile secretion matters for interpreting secretagogue claims Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited…	+5	9	1.6k	15h
Restarting after a long gap: what the labelling implies Practice › Dosing & titration dose reduction semaglutide titration missed dose Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+41	46	11k	15h
Journal club: semaglutide in MASH, and surrogate endpoints Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-2 (…	+24	28	17k	15h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURPASS-2 ( N Engl J Med ,…	+70	76	4.8k	15h
A structured critique template this community uses — a second dataset Evidence › Study critique observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+47	51	16k	15h
Chain of custody for a sample you posted yourself — one year on Sourcing › Independent verification VendorInvestigate Janoshik Analytical blind sampling third-party testing Posting this under the heading it deserves: Chain of custody for a sample you posted yourself — one year on Everything below is what sits behind that. Structured report rather than an opinion, following the…	+28	32	50k	15h
Follow-up: External review after an internal denial Access › Insurance & coverage prior authorisation formulary insurance Solved Posting this under the heading it deserves: External review after an internal denial Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is what…	+6	10	12k	15h
Fixed versus detachable needles: the trade-offs — does this still hold? Devices › Syringes & needles syringe units needle gauge & length dead volume subcutaneous injection Solved Fixed versus detachable needles: the trade-offs — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about technique rather than about…	+8	12	39k	15h
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
Molecular mass of semaglutide and why the figure differs between sources Compounds › Semaglutide SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 4 ( JAMA , 2021)…	+101	110	12k	16h
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+10	14	8.4k	16h
Coming back to: Reconciling a supplier certificate with an independent result Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers Posting this under the heading it deserves: Reconciling a supplier certificate with an independent result Everything below is what sits behind that. Structured report rather than an opinion, following the…	+26	30	45k	16h
Fibre intake when total intake falls, and the constipation link — one year on Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Fibre intake when total intake falls, and the constipation link — one year on Everything below is what sits behind that. Longitudinal report with the method stated,…	+9	13	16k	16h