20 categories

Pharmacology

Receptor biology, pharmacokinetics and formulation chemistry — the mechanistic layer under everything else.

50 topics2,108 posts5 solved Moderators: dr_okonkwo, KLindqvist About this category

Receptor biology 18 Pharmacokinetics 16 Formulation chemistry 16

50 topics · page 2 of 2

Topic	Participants	Replies	Views	Activity
GIP receptor agonism and the argument about direction Pharmacology › Receptor biology tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. A question about GIP receptor agonism that I think has a definite answer, unlike…		2	867	10mo
Vagal afferents and the gut-brain pathway — one year on Pharmacology › Receptor biology amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about Vagal afferents rather than a disguised…		2	136	11mo
Second pass at: Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Closed Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Something about Isotonicity does not reconcile and I would like a…	+1	5	2.6k	11mo
Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics missed dose worked example semaglutide Wiki Posting this under the heading it deserves: Subcutaneous absorption kinetics and site differences Everything below is what sits behind that. Asking about subcutaneous absorption kinetics and site directly,…	+15	19	3.9k	12mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am…	+5	9	44k	13mo
[2026 update] Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide worked example Solved On the subject in the title: Clearance pathways and what renal impairment changes Working notes rather than a conclusion. What changes if the standard account of Clearance pathways is wrong? I ask because I…	+63	69	50k	13mo
Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I…	+115	130	44k	13mo
Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. A narrow question about albumin binding, deliberately narrow, because the broad…	+38	44	6.6k	14mo
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about excipient function in a thread last spring and I would like to…	+3	7	36k	14mo
Excipient function in a licensed injectable — the long version Pharmacology › Formulation chemistry sterile water storage bacteriostatic water Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. A narrow question about Excipient function, deliberately…		2	100	15mo
Why appetite effects are mostly central Pharmacology › Receptor biology amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Appetite effects: what I expected, what I found, and the gap between them. I…		2	56k	16mo
Preservatives: function, testing, and limits Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. An honest uncertainty about preservatives rather than a disguised assertion. I do not know…	+23	27	3.7k	16mo
Biased agonism: a real phenomenon, an over-used explanation Pharmacology › Receptor biology semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. Trying to work out what would count as evidence on biased…	+130	135	23k	16mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. A narrow question about Albumin binding,…	+7	11	31k	17mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Biased agonism is…	+49	56	47k	17mo
Coming back to: Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry bacteriostatic water counter-ion content storage sterile water Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Adsorption — I have the observation and I do not trust my interpretation of it, so I am…		2	459	17mo
Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry sterile water counter-ion content storage On the subject in the title: Isotonicity and what happens when you get it wrong Working notes rather than a conclusion. I was wrong about isotonicity in a thread last spring and I would like to correct it…	+27	31	11k	18mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the confusion here is…	+151	163	9.7k	21mo
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. A formulation question rather than a pharmacological one, though the two…	+11	15	51k	21mo
Second pass at: Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water Wiki Second pass at: Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Buffers. It is mine, it is…	+24	28	1.5k	21mo