Latest topics page 10

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 10 of 52

Topic	Participants	Replies	Views	Activity
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Risk-of-bias tools on behalf of…	+26	30	5.8k	23h
[2026 update] Comparing prices across jurisdictions without misleading yourself Access › Pricing formulary compounding data table On the subject in the title: Comparing prices across jurisdictions without misleading yourself Working notes rather than a conclusion. Comparing prices across jurisdictions keeps being re-asked here and I…		2	809	23h
Why a pen's dose steps are fixed and what that costs you Devices › Pens & autoinjectors dead volume storage subcutaneous injection missed dose Solved The question in the title: Why a pen's dose steps are fixed and what that costs you I will give what I have already checked below so nobody repeats it. A question about a device rather than about a compound,…		4	2.5k	23h
What "marked as solution" means and who gets to mark it Start Here › Welcome beginner friendly trust levels guidelines onboarding Solved Asking directly, because I could not find a straight answer: What "marked as solution" means and who gets to mark it Question in the title. Context below, and I have tried to include the things people here…		2	290	1d
Tracking semaglutide's approved indications across jurisdictions, dated Compounds › Semaglutide semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a…	+15	19	2.8k	1d
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. Proposing that historical amylin analogues deserves a maintained…	+29	36	31k	1d
What steady state means for the decision to escalate Practice › Dosing & titration semaglutide titration tirzepatide missed dose Solved What steady state means for the decision to escalate — that is the question, and I have not found it answered plainly anywhere I have looked. A question about steady state that I think has a definite answer,…	+31	35	2k	1d
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Asking about pooling trials with different estimands on behalf of the question I keep seeing asked…	+120	132	2.3k	1d
A structured critique template this community uses Evidence › Study critique observational data effect size risk of bias A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Structured critique template — I have the observation and I do not trust my…		2	18k	1d
Selection into a registry and what it does to the estimate — a second dataset Evidence › Study critique confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Posting a small dataset on Selection. It is…	+28	32	1.3k	1d
Peer-to-peer review: what actually happens on the call Access › Insurance & coverage prior authorisation appeals formulary On the subject in the title: Peer-to-peer review: what actually happens on the call Working notes rather than a conclusion. The question about peer-to-peer review that I actually want answered is the second…		2	1.2k	1d
Micro-titration: a disputed topic, argued properly — one year on Practice › Dosing & titration dose reduction missed dose semaglutide Posting this under the heading it deserves: Micro-titration: a disputed topic, argued properly — one year on Everything below is what sits behind that. Reading back through what has been written here about…	+63	68	35k	1d
Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration aseptic technique subcutaneous injection missed dose needle gauge & length Wiki Posting this under the heading it deserves: Completing a dose with a second syringe, and the dead-volume arithmetic Everything below is what sits behind that. I have read the maintained page on this and I…	+65	76	7.4k	1d
Travelling with an injectable: documentation and practicalities Access › International NHS personal import EMA MHRA Posting this under the heading it deserves: Travelling with an injectable: documentation and practicalities Everything below is what sits behind that. Documenting a stated criterion rather than an outcome,…	+37	42	2.1k	1d
Reading U-100 graduations, with a conversion table Devices › Syringes & needles dead volume worked example subcutaneous injection needle gauge & length Posting this under the heading it deserves: Reading U-100 graduations, with a conversion table Everything below is what sits behind that. A question about reading U-100 graduations that I think has a definite…	+35	41	2k	1d
Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis observational data tesamorelin GHRP class CJC-1295 Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. What changes if the standard account of tesamorelin is…	+23	27	3.4k	1d
Coming back to: Why I now write the concentration on the vial in marker Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example The question in the title: Why I now write the concentration on the vial in marker I will give what I have already checked below so nobody repeats it. Writing this out with the numbers in it, because…	+8	12	4.3k	1d
Revisiting: Taste changes and food aversion, reported and discussed Practice › Side effects nausea vomiting constipation Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+20	25	4.3k	1d
Subgroup analyses: pre-specified versus discovered Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Subgroup analyses: pre-specified versus discovered — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on subgroup analyses, and I…		2	27k	1d
[2026 update] Journal club: what we got wrong in an earlier session Evidence › Journal club journal club effect size estimand number needed to treat Solved Journal club: what we got wrong in an earlier session — setting out what I have, and where I think it stops being reliable. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+5	9	4.2k	1d
Type 2 diabetes and the largest part of the evidence base — does this still hold? Clinical › Comorbidities type 2 diabetes chronic kidney disease PCOS blood pressure Solved Type 2 diabetes and the largest part of the evidence base — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Trying to work out what would count…	+17	22	4.5k	1d
What changed in 2026, by region — does this still hold? Access › International personal import MHRA EMA telehealth Solved What changed in 2026, by region — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated, because everything in…	+20	25	50k	1d
Follow-up: Signs of dehydration worth acting on Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia Posting this under the heading it deserves: Signs of dehydration worth acting on Everything below is what sits behind that. A follow-up question about Signs of dehydration worth acting that I did not know to…	+35	39	9.8k	1d
Asking a follow-up: new topic or new reply? Start Here › How to Ask worked example onboarding beginner friendly Solved Asking a follow-up: new topic or new reply? — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about asking a follow-up in one place, because it…	+68	73	40k	1d
BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? Compounds › Repair & healing peptides observational data needs a source BPC-157 TB-500 Solved The question in the title: BPC-157: what the rodent literature actually shows, and what it does not — does this still hold? I will give what I have already checked below so nobody repeats it. I would like to…	+6	10	3.1k	1d
Coming back to: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration dose reduction semaglutide titration tirzepatide Solved Posting this under the heading it deserves: Where the four-week escalation interval comes from, and what it is not Everything below is what sits behind that. Four-week escalation interval — I have the…	+44	48	11k	1d
How much of the diluent volume the powder itself displaces Practice › Reconstitution concentration maths bacteriostatic water dead volume worked example Asking directly, because I could not find a straight answer: How much of the diluent volume the powder itself displaces Writing this out with the numbers in it, because "roughly" is how these go wrong. Vial:…		2	1.8k	1d
Coming back to: Storing in the door of the fridge is worse than you think Practice › Storage & stability temperature excursion cold chain cloudy or discoloured solution Wiki On the subject in the title: Storing in the door of the fridge is worse than you think Working notes rather than a conclusion. Asking about the failure mode rather than the procedure, because the procedure is…	+2	6	2.1k	1d
Hair shedding at month three: mechanism and time course — the long version Practice › Side effects nausea delayed gastric emptying vomiting Hair shedding at month three: mechanism and time course — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+50	54	50k	1d
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+63	74	11k	1d