Latest topics page 11
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 11 of 52
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Gradient steepness and apparent purity: a worked comparison — the long version
Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Gradient steepness and apparent…
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2 | 32k | 1d | |
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[2026 update] Temperature indicator cards: worth asking for?
Temperature indicator cards: worth asking for? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about Temperature indicator cards on behalf of the question I…
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+21 | 26 | 4.5k | 1d |
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Cleaning a self-reported dataset and what you throw away
Cleaning a self-reported dataset and what you throw away — setting out what I have, and where I think it stops being reliable. Collecting what is known about cleaning a self-reported dataset in one place,…
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2 | 28k | 1d | |
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Washout with a one-week half-life: the arithmetic — does this still hold?
Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Washout: setting out the arithmetic in full,…
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+41 | 45 | 12k | 1d |
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[2026 update] Documenting an adverse event properly
Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about Documenting an adverse event on behalf of the question I keep seeing asked…
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+18 | 22 | 4.3k | 1d |
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Why the Start Here categories exist, and what they are not for
Why the Start Here categories exist, and what they are not for — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about Start in one place,…
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+40 | 44 | 32k | 1d |
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile
Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. Semaglutide and gastric emptying,…
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+115 | 122 | 2.6k | 1d |
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Sulphur-smelling eructation: mechanism and what helps
Sulphur-smelling eructation: mechanism and what helps — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on sulphur-smelling…
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2 | 58 | 1d | |
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset
Posting this under the heading it deserves: Muscle cramps: the ordinary causes before the exotic ones — a second dataset Everything below is what sits behind that. Something about Muscle cramps does not…
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+65 | 77 | 39k | 1d |
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Publication bias detection and its low power
On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. Working notes on publication bias detection rather than a conclusion. I would rather post the…
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2 | 3.2k | 1d | |
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Conditions that change the calculus rather than forbidding it
Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of conditions is wrong? I…
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+28 | 32 | 6.1k | 1d |
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Type 1 diabetes: off-label use and the evidence gap
On the subject in the title: Type 1 diabetes: off-label use and the evidence gap Working notes rather than a conclusion. Type 1 diabetes, and specifically the version of it that the documentation does not…
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2 | 2.3k | 1d | |
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Splitting an overlong document into two
Posting this under the heading it deserves: Splitting an overlong document into two Everything below is what sits behind that. Trying to work out what would count as evidence on splitting an overlong…
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+30 | 34 | 6.2k | 1d |
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What is genuinely unknown about long-term amylin agonism
What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. A comparison question rather than a question about one…
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+83 | 91 | 46k | 1d |
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Why the absence of controlled human data on BPC-157 matters more than people admit
Why the absence of controlled human data on BPC-157 matters more than people admit — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people…
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+60 | 66 | 16k | 1d |
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Pinch or no pinch, and how needle length changes the answer — what changed since
Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. What changes if the standard account of…
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+58 | 62 | 16k | 1d |
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System suitability injections: if they failed, the run did not happen — the long version
System suitability injections: if they failed, the run did not happen — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about System suitability…
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+2 | 6 | 6.2k | 1d |
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Revisiting: How this community labels and discusses unrefereed work
Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. Reading an unrefereed manuscript properly, and asking…
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+31 | 35 | 7k | 1d |
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Peak-to-trough ratio at steady state for a weekly agent — the long version
Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Peak-to-trough ratio,…
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+57 | 61 | 708 | 1d |
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What published stability data actually covers, and what it does not
Asking directly, because I could not find a straight answer: What published stability data actually covers, and what it does not A question about published stability data actually covers that I think has a…
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+8 | 12 | 435 | 1d |
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Journal club: SUSTAIN 6 and its retinopathy signal
On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…
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+110 | 122 | 46k | 1d |
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Revisiting: The report format the maintainers ask for, and why each field is there
Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…
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+100 | 108 | 57k | 1d |
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Distinguishing a red flag from an inconvenience — a second dataset
On the subject in the title: Distinguishing a red flag from an inconvenience — a second dataset Working notes rather than a conclusion. Posting a small dataset on Distinguishing a red flag. It is mine, it is…
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+8 | 12 | 9.6k | 1d |
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Athletes in weight-category sports: a different risk calculus
Athletes in weight-category sports: a different risk calculus — setting out what I have, and where I think it stops being reliable. Something about athletes in weight-category sports does not reconcile and I…
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+38 | 42 | 6.6k | 1d |
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The five documentation pages worth reading before you post anything — a second dataset
On the subject in the title: The five documentation pages worth reading before you post anything — a second dataset Working notes rather than a conclusion. Posting a small dataset on five documentation pages.…
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2 | 24k | 1d | |
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Research-use-only status: what it means legally and practically
Research-use-only status: what it means legally and practically Writing it up because I had to work it out twice and would rather nobody else did. Asking about research-use-only status directly, because I…
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+72 | 81 | 44k | 1d |
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Does a peptide degrade silently, with no visual change?
Does a peptide degrade silently, with no visual change? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of peptide is wrong? I…
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+73 | 79 | 1.3k | 1d |
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PCOS and metabolic overlap: what is and is not studied
On the subject in the title: PCOS and metabolic overlap: what is and is not studied Working notes rather than a conclusion. PCOS and metabolic overlap, from the point of view of someone who has read the…
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3 | 6.6k | 1d | |
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An appeal that succeeded, with the letter structure
On the subject in the title: An appeal that succeeded, with the letter structure Working notes rather than a conclusion. Appeal, and specifically the version of it that the documentation does not cover. The…
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+12 | 16 | 15k | 1d |
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The most useful thing you learned here that was not the answer you came for
The most useful thing you learned here that was not the answer you came for Writing it up because I had to work it out twice and would rather nobody else did. A digression I have been saving for the right…
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+54 | 61 | 57k | 1d |