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Evidence · Preprints

The "under review" status pill and when a moderator applies it

N
NLoughranTL3Regular25 Feb 2026#1

Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that.

Session topic: SURMOUNT-4 (JAMA, 2024). Please read it before posting; the discussion is much better when everyone has.

The question I would like us to start with is what the trial set out to estimate, rather than what it found. Once that is on the table we can talk about whether the design could have answered it, and only then about the numbers.

Specific things I would like covered: the population and how far it generalises, how discontinuation was handled, whether the comparator was a fair one, and what the absolute rather than relative effect looks like.

I will summarise at the end and the summary will feed the relevant digest page.

0 likes 5mo
LA
l.aguirreTL2 Moderator27 Feb 2026 · edited#2

On the opening post — agreed on the reasoning, with one qualification.

Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real.

2 likes 5mo
MD
m.duarteTL2 Moderator28 Feb 2026#3

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

13 likes 5mo
OV
o.vogelTL2 Moderator1 Mar 2026#4

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

27 likes 5mo
RV
r.villalobosTL2 Moderator2 Mar 2026#5
l.aguirre, post #2: On the opening post — agreed on the reasoning, with one qualification. Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real. Go to post

Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for understanding emerging evidence, not for drawing definitive conclusions.

0 likes in reply to #2 5mo
RD
r.danquahTL2 Moderator3 Mar 2026#6

Worth separating two things that post #2 runs together.

Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists.

0 likes 5mo
KF
k.fonsecaTL2 Moderator4 Mar 2026#7

This follows post #4 rather than contradicting it.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

8 likes 5mo
KV
k.vanheckeTL2 Moderator5 Mar 2026#8

Unrefereed work is not worthless. A great deal of it survives review substantially unchanged. It is also the case that the version appearing in a journal frequently has different numbers, and the changes are not random — they tend to be in the direction of a smaller effect and a more careful claim.

20 likes 5mo
W
WoodhouseTL2Member6 Mar 2026 · edited#9

Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere. Citing the preprint with its DOI is appropriate while noting it is unpublished.

28 likes 5mo
ZV
z.vogelTL2 Moderator7 Mar 2026#10
r.danquah, post #6: Worth separating two things that post #2 runs together. Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists. Go to post

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

0 likes in reply to #6 5mo
NK
n.krastevTL2 Moderator7 Mar 2026#11

Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but publication history is a difference worth noting.

12 likes 5mo
DO
d.oyelaranTL3Pharmacist8 Mar 2026#12

Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to differ if the paper is later published differently.

4 likes 5mo
CT
c.tullochTL2 Moderator9 Mar 2026#13

On post #9 — agreed on the reasoning, with one qualification.

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

0 likes 5mo
K
KLindqvistTL4 Moderator10 Mar 2026 · edited#14
o.vogel, post #4: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post
Staff post. Actions described here are recorded in the public moderation log and may be challenged in Meta.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes in reply to #4 5mo
JI
j.iyerTL2 Moderator11 Mar 2026#15
d.oyelaran, post #12: Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to differ if the paper is later published differently. Go to post

Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real.

7 likes in reply to #12 5mo
BV
bias_varianceTL4Biostatistician11 Mar 2026#16

Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published, your reasoning based on the preprint needs to be revised.

1 like 5mo
IA
id.almeidaTL2 Moderator12 Mar 2026#17

Worth separating two things that post #13 runs together.

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

0 likes 5mo
BD
baseline_driftTL2Analytical chemist13 Mar 2026#18
o.vogel, post #4: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

post #17 is right about the mechanism and I think understates the practical bit.

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

25 likes in reply to #4 5mo
PA
p.amankwahTL2 Moderator13 Mar 2026#19

Coming back to post #17, because the follow-up matters more than the original answer.

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

24 likes 4mo
IC
i.coelhoTL2 Moderator14 Mar 2026#20

Picking up post #17: that is the part I would want checked first.

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

11 likes 4mo
CL
coldchain_liuTL3Regular15 Mar 2026#21

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes 4mo
AI
a.ilungaTL2 Moderator16 Mar 2026#22
r.danquah, post #6: Worth separating two things that post #2 runs together. Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists. Go to post

Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists.

0 likes in reply to #6 4mo
AF
a.finnegan_rdTL2Dietitian16 Mar 2026#23
c.tulloch, post #13: On post #9 — agreed on the reasoning, with one qualification. How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint. Go to post

post #22 answers the question as asked. The question underneath it is different.

Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to differ if the paper is later published differently.

9 likes in reply to #13 4mo
MN
m.nascimentoTL2 Moderator17 Mar 2026#24

On post #20 — agreed on the reasoning, with one qualification.

Unrefereed work is not worthless. A great deal of it survives review substantially unchanged. It is also the case that the version appearing in a journal frequently has different numbers, and the changes are not random — they tend to be in the direction of a smaller effect and a more careful claim.

21 likes 4mo
VS
v.szaboTL3Analytical chemist18 Mar 2026#25

Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but publication history is a difference worth noting.

30 likes 4mo
VK
v.kirchnerTL2 Moderator18 Mar 2026 · edited#26
o.vogel, post #4: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for understanding emerging evidence, not for drawing definitive conclusions.

0 likes in reply to #4 4mo
SK
s.karlsen_rphTL3Pharmacist19 Mar 2026#27

Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere. Citing the preprint with its DOI is appropriate while noting it is unpublished.

5 likes 4mo
HV
h.vargaTL2 Moderator20 Mar 2026#28

Worth separating two things that post #24 runs together.

Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real.

15 likes 4mo
K
KLindqvistTL4 Moderator20 Mar 2026#29
a.finnegan_rd, post #23: post #22 answers the question as asked. The question underneath it is different. Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to differ if the paper is later published differently. Go to post

Picking up post #26: that is the part I would want checked first.

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

22 likes in reply to #23 4mo
KL
k.laurentTL2 Moderator21 Mar 2026#30
l.aguirre, post #2: On the opening post — agreed on the reasoning, with one qualification. Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having survived peer review. The trade-off is real. Go to post

Coming back to post #28, because the follow-up matters more than the original answer.

Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere. Citing the preprint with its DOI is appropriate while noting it is unpublished.

0 likes in reply to #2 4mo