Tags · Evidence

risk of bias

Structured appraisal of internal validity.

83 topics 21 solved Group: Evidence

83 topics · page 3 of 3

Topic	Participants	Replies	Views	Activity
A claim built entirely on a subgroup analysis Evidence › Study critique risk of bias observational data confounding disputed Solved A claim built entirely on a subgroup analysis Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do…	+71	80	1.1k	14mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with LEADER ( N Engl J Med ,…	+117	128	7.2k	14mo
Critiquing an observational claim about a class effect Evidence › Study critique disputed risk of bias effect size observational data Posting this under the heading it deserves: Critiquing an observational claim about a class effect Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…		2	6.9k	14mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not…		2	1.3k	14mo
Criticising the method without criticising the authors Evidence › Study critique disputed observational data confounding effect size Criticising the method without criticising the authors Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim…	+55	61	60k	15mo
Journal club: STEP 4 and what a withdrawal design can prove — one year on Evidence › Journal club number needed to treat estimand randomised trial effect size Closed Journal club: STEP 4 and what a withdrawal design can prove — one year on Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024).…	+56	62	34k	15mo
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club risk of bias number needed to treat randomised trial Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+118	132	12k	15mo
Follow-up: Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club randomised trial risk of bias effect size journal club Closed On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not…	+20	24	8.7k	16mo
Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? Evidence › Journal club journal club effect size number needed to treat randomised trial The question in the title: Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet ,…	+60	66	12k	16mo
About the Study critique category Evidence › Study critique risk of bias confounding observational data Pinned Wiki Structured criticism of a specific published study. Criticise the method, not the author. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…		4	114	16mo
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club randomised trial effect size journal club risk of bias Solved Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SCALE ( N Engl J…	+47	51	617	16mo
Coming back to: Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses meta-analysis publication bias heterogeneity risk of bias Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+30	34	9.3k	17mo
Random versus fixed effects: choosing rather than defaulting — a second dataset Evidence › Meta-analyses heterogeneity risk of bias publication bias On the subject in the title: Random versus fixed effects: choosing rather than defaulting — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it…	+95	106	20k	17mo
A claim built entirely on a subgroup analysis — what changed since Evidence › Study critique disputed effect size observational data risk of bias Closed On the subject in the title: A claim built entirely on a subgroup analysis — what changed since Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…		2	2k	18mo
A well-designed study with a badly written abstract — does this still hold? Evidence › Study critique disputed confounding risk of bias Solved Closed A well-designed study with a badly written abstract — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021)…		2	28k	20mo
Second pass at: When a network meta-analysis is defensible and when it is not Evidence › Meta-analyses heterogeneity meta-analysis effect size publication bias Solved Pinned Posting this under the heading it deserves: Second pass at: When a network meta-analysis is defensible and when it is not Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with LEADER…		2	2.8k	21mo
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand effect size risk of bias journal club Solved On the subject in the title: Journal club: SURPASS-2 and the semaglutide 1 mg comparator Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting;…	+71	76	52k	21mo
Tracking a preprint to publication: a worked example — the long version Evidence › Preprints risk of bias preprint effect size Posting this under the heading it deserves: Tracking a preprint to publication: a worked example — the long version Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 2 (…	+38	47	560	22mo
Coming back to: Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses publication bias heterogeneity effect size risk of bias Prediction intervals and why they are more honest than confidence intervals Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024)…		2	65	22mo
Why a preprint's supplementary material is often the best part Evidence › Preprints needs a source risk of bias preprint effect size Why a preprint's supplementary material is often the best part I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…	+38	42	863	22mo
Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Posting this under the heading it deserves: Reading a meta-analysis you disagree with, fairly Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+7	13	2.5k	23mo
How this community labels and discusses unrefereed work Evidence › Preprints risk of bias effect size preprint needs a source How this community labels and discusses unrefereed work — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited in support of a…	+112	119	1.3k	2y
Journal club: FLOW and the renal composite, component by component Evidence › Journal club randomised trial estimand risk of bias On the subject in the title: Journal club: FLOW and the renal composite, component by component Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…	+84	91	18k	2y