Compounds · subcategory

Semaglutide

GLP-1 receptor agonist. Dosing, published trial data, tolerability, and formulation questions.

35 topics1,718 posts12 solved Moderators: t.vasquez, j.mwangi About this category

semaglutide STEP programme SELECT trial randomised trial effect size type 2 diabetes

35 topics

Topic	Participants	Replies	Views	Activity
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since STEP programme type 2 diabetes randomised trial effect size Posting this under the heading it deserves: Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Everything below is what sits behind that. Putting the numbers in the first…	+125	132	39k	16mo
Semaglutide half-life: where the 165 to 184 hour figure comes from semaglutide effect size randomised trial type 2 diabetes Wiki Semaglutide half-life: where the 165 to 184 hour figure comes from — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a question about a…	+128	145	3k	4mo
What SELECT changed about how semaglutide is discussed, and what it did not STEP programme type 2 diabetes randomised trial Solved Asking directly, because I could not find a straight answer: What SELECT changed about how semaglutide is discussed, and what it did not I was wrong about SELECT in a thread last spring and I would like to…	+120	132	2k	14mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. Semaglutide and gastric emptying,…	+115	122	2.6k	1d
What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset STEP programme randomised trial SELECT trial type 2 diabetes Solved Asking directly, because I could not find a straight answer: What the published dose-response for semaglutide actually looks like above 2.4 mg — a second dataset Two things I would like separated before…	+112	130	2.2k	16mo
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from SELECT trial type 2 diabetes semaglutide Semaglutide half-life: where the 165 to 184 hour figure comes from Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a question…	+112	119	3.3k	11mo
Molecular mass of semaglutide and why the figure differs between sources SELECT trial effect size semaglutide STEP programme Molecular mass of semaglutide and why the figure differs between sources — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a question about a…	+101	110	12k	16h
Molecular mass of semaglutide and why the figure differs between sources — does this still hold? effect size type 2 diabetes STEP programme SELECT trial Solved Closed Molecular mass of semaglutide and why the figure differs between sources — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in…	+94	102	14k	19mo
Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? randomised trial type 2 diabetes STEP programme effect size Solved Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Practical question…	+58	62	49k	20mo
Why semaglutide solutions can look faintly opalescent and when that matters semaglutide SELECT trial randomised trial effect size Solved The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. A follow-up question about…	+73	79	2k	4mo
Semaglutide versus liraglutide head to head: reading STEP 8 carefully STEP programme SELECT trial randomised trial type 2 diabetes Under review On the subject in the title: Semaglutide versus liraglutide head to head: reading STEP 8 carefully Working notes rather than a conclusion. I would like to disagree carefully with the settled view on…	+72	81	1.5k	9mo
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide effect size type 2 diabetes randomised trial Solved Posting this under the heading it deserves: Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Everything below is what sits behind that. I have spent a fortnight trying…	+72	77	7.2k	19mo
The C-cell question: rodent findings and their human context — what changed since effect size SELECT trial randomised trial type 2 diabetes Closed The C-cell question: rodent findings and their human context — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of c-cell question…	+61	65	1.3k	22mo
The C-cell question: rodent findings and their human context STEP programme type 2 diabetes effect size Closed Posting this under the heading it deserves: The C-cell question: rodent findings and their human context Everything below is what sits behind that. The question about c-cell question that I actually want…	+41	45	24k	12mo
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like effect size randomised trial SELECT trial On the subject in the title: Semaglutide in people without diabetes: what the evidence base looks like Working notes rather than a conclusion. Two things I would like separated before anyone answers on…	+41	46	1.2k	4mo
Why semaglutide's albumin binding is the whole reason weekly dosing works STEP programme SELECT trial randomised trial effect size Solved Closed Asking directly, because I could not find a straight answer: Why semaglutide's albumin binding is the whole reason weekly dosing works Putting the numbers in the first post, because a question about a…		2	63k	5mo
The most common factual error about semaglutide on the internet — what changed since effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a…	+42	46	1.7k	5mo
Coming back to: What the published dose-response for semaglutide actually looks like above 2.4 mg effect size type 2 diabetes semaglutide STEP programme Solved The question in the title: What the published dose-response for semaglutide actually looks like above 2.4 mg I will give what I have already checked below so nobody repeats it. I would like to know what…	+23	27	9.9k	1mo
The most common factual error about semaglutide on the internet STEP programme randomised trial type 2 diabetes effect size On the subject in the title: The most common factual error about semaglutide on the internet Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a compound…		2	49k	2y
Semaglutide formulation: what is in the licensed product besides the peptide SELECT trial type 2 diabetes semaglutide Semaglutide formulation: what is in the licensed product besides the peptide — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin semaglutide…	+29	35	4.4k	1h
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? type 2 diabetes randomised trial semaglutide SELECT trial Solved Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in the first…	+5	9	30k	8d
Coming back to: Why semaglutide solutions can look faintly opalescent and when that matters SELECT trial randomised trial STEP programme Asking directly, because I could not find a straight answer: Why semaglutide solutions can look faintly opalescent and when that matters Reading back through what has been written here about semaglutide…	+16	20	17k	13mo
Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works SELECT trial STEP programme effect size randomised trial Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first…		2	39k	6mo
Semaglutide and alcohol: what is actually documented STEP programme randomised trial type 2 diabetes SELECT trial Posting this under the heading it deserves: Semaglutide and alcohol: what is actually documented Everything below is what sits behind that. I would like to know what people here actually do about semaglutide…	+14	18	10k	2d
Tracking semaglutide's approved indications across jurisdictions, dated semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a…	+15	19	2.8k	1d
Semaglutide in people without diabetes: what the evidence base looks like semaglutide effect size STEP programme randomised trial Semaglutide in people without diabetes: what the evidence base looks like Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of semaglutide…	+2	6	18k	17mo
Second pass at: Semaglutide and alcohol: what is actually documented semaglutide type 2 diabetes effect size randomised trial Closed Second pass at: Semaglutide and alcohol: what is actually documented Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+15	19	4.4k	13mo
Is there a ceiling dose beyond which semaglutide stops adding benefit? effect size type 2 diabetes SELECT trial Is there a ceiling dose beyond which semaglutide stops adding benefit? I have a specific reason for asking rather than idle curiosity, and the context is below. Putting the numbers in the first post, because…		2	14k	2mo
Follow-up: Semaglutide versus liraglutide head to head: reading STEP 8 carefully effect size randomised trial SELECT trial STEP programme Semaglutide versus liraglutide head to head: reading STEP 8 carefully — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on…	+1	5	11k	20mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since semaglutide SELECT trial type 2 diabetes STEP programme Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard…	+6	10	6.1k	8mo

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