Latest topics page 13

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 13 of 52

Topic	Participants	Replies	Views	Activity
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. Alcohol, and specifically the version of it that the documentation does…	+120	134	11k	2d
What a certificate commits its issuer to — the long version Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards certificate of analysis Asking directly, because I could not find a straight answer: What a certificate commits its issuer to — the long version A documentation question rather than an analytical one. I have a certificate in front…	+20	26	21k	2d
Impurity thresholds: where the common numbers come from Analytics › Impurities & related substances water content data table forced degradation counter-ion content Impurity thresholds: where the common numbers come from — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin impurity thresholds down and I want to set…	+11	15	825	2d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume Asking about the record rather than the transfer. Every order leaves a trail: an order…	+22	26	2.5k	2d
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes prior authorisation Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. A question about how to describe something to a clinician rather than about the…	+51	56	1.4k	2d
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback data table Solved Posting this under the heading it deserves: A community side-effect dataset, with its response rate and biases Everything below is what sits behind that. Community side-effect dataset — I have the observation…	+96	101	33k	2d
NHS criteria and how they are applied in practice Regional › UK & Ireland NHS cost per milligram personal import MHRA NHS criteria and how they are applied in practice — setting out what I have, and where I think it stops being reliable. I was wrong about NHS criteria in a thread last spring and I would like to correct it…	+37	42	31k	2d
Stepping down deliberately, and how to do it without losing progress — what changed since Practice › Dosing & titration tirzepatide semaglutide titration missed dose Under review Posting this under the heading it deserves: Stepping down deliberately, and how to do it without losing progress — what changed since Everything below is what sits behind that. Something changed and I would…	+94	99	29k	2d
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Collecting what is known about forced degradation studies…	+100	106	35k	2d
Designing a personal experiment that could change your mind — one year on Research Methods › N-of-1 designs effect size data table worked example Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…	+74	80	17k	2d
Why catalogue breadth is not evidence of anything Compounds › Other compounds research use only needs a source custom synthesis Under review Why catalogue breadth is not evidence of anything I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of catalogue breadth is wrong?…		2	38k	2d
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC UV & DAD detection system suitability peak integration gradient method Solved Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…	+1	5	719	2d
[2026 update] A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports batch & lot numbers third-party testing documentation quality certificate of analysis On the subject in the title: A report I filed that turned out to be wrong, and the correction Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+15	19	18k	2d
Batch numbers that do not match the vial label Sourcing › Red flags mislabelling disputed moderation underdosing Solved Batch numbers that do not match the vial label — setting out what I have, and where I think it stops being reliable. Structured question about turnaround and what it signals. I have started recording how long…	+43	48	8.9k	2d
Coming back to: Payment method and the leverage it gives you, ranked Sourcing › Payments payments documentation quality research use only Payment method and the leverage it gives you, ranked — setting out what I have, and where I think it stops being reliable. A payments question, with the mechanics separated from the money. What I would like…	+21	26	43k	2d
How shortages have affected compounding permissions Access › Shortages shortage compounding FDA formulary How shortages have affected compounding permissions I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what people here actually do about shortages,…	+61	71	3.6k	2d
Ultrasound and skinfolds: operator dependence in practice Outcomes › Body composition DXA data table lean mass loss Ultrasound and skinfolds: operator dependence in practice — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on ultrasound and skinfolds. The…	+72	76	2.7k	2d
Revisiting: Protein density versus volume when you cannot eat much Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Revisiting: Protein density versus volume when you cannot eat much Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin Protein density…	+97	108	3.6k	2d
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Programming during a large energy: what I expected, what I found, and the gap between them. I am…	+39	49	36k	2d
Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date promoted to docs wiki post On the subject in the title: Review: an evidence digest and the citation check that delayed it Working notes rather than a conclusion. I was wrong about evidence digest in a thread last spring and I would…	+13	17	15k	2d
Follow-up: UK access routes, dated and sourced Regional › UK & Ireland personal import cost per milligram MHRA Solved On the subject in the title: UK access routes, dated and sourced Working notes rather than a conclusion. Regional question, dated March 2026, because everything in this category expires. The position differs…	+10	14	27k	2d
Why the timeline is on the right and not the left — what changed since Meta › Site feedback site feedback moderation guidelines Solved Why the timeline is on the right and not the left — what changed since I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of…	+77	81	4k	2d
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Compounds › Retatrutide retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. I would like to disagree…	+43	47	19k	2d
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. I was wrong about pooled estimate in a thread last spring and I would like to…	+24	28	3.5k	2d
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how this site should cite something…	+109	116	36k	2d
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on PCOS and metabolic…	+55	59	26k	2d
[2026 update] Currency conversion and the cost you did not see Sourcing › Payments research use only payments documentation quality Solved Posting this under the heading it deserves: Currency conversion and the cost you did not see Everything below is what sits behind that. Currency and fees, set out so that the comparison can be checked. Quoted…	+21	26	52k	2d
When your prescriber and the evidence disagree Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. What changes if the standard account of prescriber is wrong? I ask…	+14	18	273	2d
Priming a pen and whether the primed volume is wasted Devices › Pens & autoinjectors storage missed dose dead volume Solved Wiki Priming a pen and whether the primed volume is wasted Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin priming a pen down and I want to…	+19	23	1.3k	2d