Latest topics page 20

Posting this under the heading it deserves: Anaesthesia and elective surgery: the aspiration question Everything below is what sits behind that. A narrow question about anaesthesia and elective surgery,…

Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. A question about how this site should cite something that…

What "marked as solution" means and who gets to mark it — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather…

Reimbursement variation across member states Writing it up because I had to work it out twice and would rather nobody else did. Asking about reimbursement variation across member states directly, because I…

Revisiting: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view…

Second pass at: What "verified" means on our vendor pages, stated narrowly — setting out what I have, and where I think it stops being reliable. A question about how a record should be read rather than about…

Request: show the solution author in the topic list — what changed since — setting out what I have, and where I think it stops being reliable. Bringing the figures rather than the impression, since a process…

On the subject in the title: A widely repeated interaction claim that turns out to be unsupported Working notes rather than a conclusion. I was wrong about widely repeated interaction claim in a thread last…

Primary endpoint hierarchies and why order matters Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about primary endpoint hierarchies in a thread last spring and…

Stepping down deliberately, and how to do it without losing progress — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…

On the subject in the title: Charge states for a 4 kDa peptide, worked through Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…

Validating a calculator against hand arithmetic Writing it up because I had to work it out twice and would rather nobody else did. Validating a calculator against hand: setting out the arithmetic in full,…

On the subject in the title: Validating a method you did not develop Working notes rather than a conclusion. What changes if the standard account of validating a method is wrong? I ask because I have been…

Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. Trying to work out what would count as evidence on type 2…

Journal club: is percentage weight change the right endpoint? I have a specific reason for asking rather than idle curiosity, and the context is below. Bringing a claim rather than a paper, because the claim…

Foaming during reconstitution and whether it matters — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Foaming during reconstitution,…

Asking directly, because I could not find a straight answer: Why this community will not facilitate a group purchase Currency and fees, set out so that the comparison can be checked. Quoted amount, conversion…

Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Measurement error, three questions…

On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…

Posting this under the heading it deserves: Impurity thresholds: where the common numbers come from — what changed since Everything below is what sits behind that. What changes if the standard account of…

What a statistical analysis plan adds that the paper does not I have a specific reason for asking rather than idle curiosity, and the context is below. A follow-up question about statistical analysis plan…

Converting between mg/mL and units per dose, both directions — the long version Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…

Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on sample handling between…

Managing an unplanned gap in supply — setting out what I have, and where I think it stops being reliable. A narrow question about managing an unplanned gap, deliberately narrow, because the broad version has…

The question in the title: What a purity-only report leaves out I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following the format the…

Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. Pregnancy and pregnancy planning: setting out the…

Posting this under the heading it deserves: Severe abdominal pain: why this is not a forum question Everything below is what sits behind that. Severe abdominal pain, and specifically the version of it that…

How to tell whether your question is already answered on a maintained page — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…

Price changes over 2025 and 2026, tabulated and dated — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated,…

Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on SURMOUNT-4 and continuation…