Latest topics page 19

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 19 of 52

Topic	Participants	Replies	Views	Activity
Secretagogues and glucose tolerance: the mechanistic concern — what changed since Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 observational data Wiki Closed Secretagogues and glucose tolerance: the mechanistic concern — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of…	+2	6	31k	2mo
Revisiting: The arithmetic of an intermediate dose between two label steps Practice › Dosing & titration titration worked example dose reduction tirzepatide Revisiting: The arithmetic of an intermediate dose between two label steps Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+41	45	808	2mo
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? Data & Tools › Datasets data table confounding observational data Solved Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. An honest uncertainty about…	+14	18	3.4k	2mo
Why retatrutide discussion here is more cautious than elsewhere Compounds › Retatrutide randomised trial effect size retatrutide preprint Solved Why retatrutide discussion here is more cautious than elsewhere I have a specific reason for asking rather than idle curiosity, and the context is below. A question about retatrutide discussion that I think…	+7	12	7.7k	2mo
Residual solvents and scavengers: what is looked for — what changed since Analytics › Impurities & related substances forced degradation water content data table HPLC Solved Residual solvents and scavengers: what is looked for — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Residual solvents and…	+37	41	7k	2mo
Currency conversion and the cost you did not see Sourcing › Payments payments research use only documentation quality Currency conversion and the cost you did not see — setting out what I have, and where I think it stops being reliable. Currency and fees, set out so that the comparison can be checked. Quoted amount,…		2	44k	2mo
Reused chromatograms across lots: how to spot it — what changed since Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards documentation quality Solved Reused chromatograms across lots: how to spot it — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Reused chromatograms across…	+34	39	20k	2mo
Introducing myself: pharmacist, sceptic, reluctant participant Lounge › Introductions onboarding beginner friendly Introducing myself: pharmacist, sceptic, reluctant participant Writing it up because I had to work it out twice and would rather nobody else did. Introducing myself before I ask anything, since the welcome…	+13	17	23k	2mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Sourcing › Independent verification Janoshik Analytical blind sampling PeptideMeter VendorInvestigate Solved How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting a small dataset on…	+42	46	46k	2mo
Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Practice › Interactions needs a source delayed gastric emptying hypoglycaemia insulin Solved Closed On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter — one year on Working notes rather than a conclusion. A follow-up question about Delayed gastric…		3	16k	2mo
Measurement error in home scales, with a worked standard deviation — the long version Research Methods › Statistics number needed to treat worked example heterogeneity effect size Solved On the subject in the title: Measurement error in home scales, with a worked standard deviation — the long version Working notes rather than a conclusion. A narrow question about Measurement error in home…	+96	105	2k	2mo
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Devices › Syringes & needles dead volume needle gauge & length subcutaneous injection Solved On the subject in the title: 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Working notes rather than a conclusion. A follow-up question about 0.3 ml versus 0.5 ml that I did not know to ask the…	+108	124	27k	2mo
How this community labels and discusses unrefereed work — the long version Evidence › Preprints needs a source effect size risk of bias Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version Reading an unrefereed manuscript properly, and asking whether I am doing…	+18	23	21k	2mo
How to ask about something you suspect is a bad idea Start Here › How to Ask onboarding site feedback guidelines beginner friendly Solved The question in the title: How to ask about something you suspect is a bad idea I will give what I have already checked below so nobody repeats it. Question in the title. Context below, and I have tried to…	+81	87	16k	2mo
Request declined, with reasoning — what changed since Meta › Feature requests wiki post site feedback translation Posting this under the heading it deserves: Request declined, with reasoning — what changed since Everything below is what sits behind that. What changes if the standard account of Request declined is wrong?…	+34	38	9.4k	2mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…	+73	78	3.5k	2mo
Coming back to: Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics missed dose semaglutide worked example Closed Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that. A narrow question about Washout, deliberately narrow, because the…	+128	139	3k	3mo
Common supplements people ask about, assessed one at a time — a second dataset Practice › Interactions delayed gastric emptying insulin needs a source Posting this under the heading it deserves: Common supplements people ask about, assessed one at a time — a second dataset Everything below is what sits behind that. A follow-up question about Common…	+97	104	15k	3mo
Revisiting: Primary endpoint hierarchies and why order matters Evidence › Trials estimand surrogate endpoints discontinuation & dropout intention to treat Posting this under the heading it deserves: Revisiting: Primary endpoint hierarchies and why order matters Everything below is what sits behind that. I was wrong about Primary endpoint hierarchies in a thread…	+21	25	46k	3mo
Second pass at: Why chargeback is not the safety net people assume Sourcing › Payments documentation quality research use only payments Solved Second pass at: Why chargeback is not the safety net people assume Writing it up because I had to work it out twice and would rather nobody else did. Asking about the record rather than the transfer. Every…		2	25k	3mo
Reconstitution volumes that produce round numbers, tabulated Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example Reconstitution volumes that produce round numbers, tabulated — setting out what I have, and where I think it stops being reliable. Writing this out with the numbers in it, because "roughly" is how these go…	+103	112	1.7k	3mo
Fatigue in the first month: how much is the drug and how much is intake Practice › Side effects vomiting fatigue constipation Solved On the subject in the title: Fatigue in the first month: how much is the drug and how much is intake Working notes rather than a conclusion. Something changed and I would like to know whether it should have.…		4	17k	3mo
Temperature indicator cards: worth asking for? Sourcing › Logistics customs packaging temperature excursion shipping Asking directly, because I could not find a straight answer: Temperature indicator cards: worth asking for? Two things I would like separated before anyone answers on temperature indicator cards, because they…	+2	6	116	3mo
Pre-registering a personal experiment, seriously — a second dataset Research Methods › N-of-1 designs data table worked example confounding Posting this under the heading it deserves: Pre-registering a personal experiment, seriously — a second dataset Everything below is what sits behind that. Posting a small dataset on Pre-registering a personal…	+60	66	35k	3mo
What the published dose-response for semaglutide actually looks like above 2.4 mg Compounds › Semaglutide STEP programme type 2 diabetes effect size SELECT trial Solved What the published dose-response for semaglutide actually looks like above 2.4 mg — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people here…		2	10k	3mo
Subgroup analyses: pre-specified versus discovered — a second dataset Evidence › Trials open label discontinuation & dropout estimand randomised trial On the subject in the title: Subgroup analyses: pre-specified versus discovered — a second dataset Working notes rather than a conclusion. Posting a small dataset on Subgroup analyses. It is mine, it is…	+71	79	906	3mo
Publication bias detection and its low power — does this still hold? Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. Collecting what is known about Publication…	+24	28	2.4k	3mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. A narrow question about Absolute versus relative contraindications, deliberately…	+80	85	7.4k	3mo
Requesting a translation of an existing page — the long version Documentation › Wiki requests promoted to docs wiki post review date maintainership Closed Posting this under the heading it deserves: Requesting a translation of an existing page — the long version Everything below is what sits behind that. Requesting a translation keeps being re-asked here and I…	+2	6	5.4k	3mo
Named, unnamed and unspecified impurities as regulatory categories Analytics › Impurities & related substances counter-ion content endotoxin testing water content On the subject in the title: Named, unnamed and unspecified impurities as regulatory categories Working notes rather than a conclusion. Two reports on the same lot, and I would like help deciding whether they…	+10	14	504	3mo