Latest topics page 31

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 31 of 52

Topic	Participants	Replies	Views	Activity
Insomnia at a dose step: reported experiences Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate Solved On the subject in the title: Insomnia at a dose step: reported experiences Working notes rather than a conclusion. A sleep question with what I actually recorded rather than how I feel about it. Bedtime and…	+20	24	18k	8mo
A parcel that arrived warm: a decision process, not a verdict Practice › Storage & stability cold chain beyond-use date storage freeze-thaw Solved A parcel that arrived warm: a decision process, not a verdict Writing it up because I had to work it out twice and would rather nobody else did. Asking about the failure mode rather than the procedure,…	+130	140	12k	8mo
Reading a supplier's product description as a marketing document Compounds › Other compounds custom synthesis needs a source mislabelling On the subject in the title: Reading a supplier's product description as a marketing document Working notes rather than a conclusion. Documentation question rather than a pharmacological one, but about this…	+86	97	62k	8mo
Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide SURMOUNT programme randomised trial SURPASS programme tirzepatide Asking directly, because I could not find a straight answer: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Asking about tirzepatide and nausea directly, because I…	+18	22	37k	8mo
Coming back to: Why quantitation is the hard part, not detection Analytics › Home & field testing third-party testing documentation quality ELISA LOD & LOQ Why quantitation is the hard part, not detection — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about quantitation in one place, because it…	+86	92	54k	8mo
Where to report an adverse event officially, by region — a second dataset Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia On the subject in the title: Where to report an adverse event officially, by region — a second dataset Working notes rather than a conclusion. Reporting an event with the dates and the sequence, because…	+108	123	26k	8mo
Refrigerated versus room temperature: the trade-off stated plainly — what changed since Practice › Storage & stability temperature excursion freeze-thaw storage cloudy or discoloured solution Closed Posting this under the heading it deserves: Refrigerated versus room temperature: the trade-off stated plainly — what changed since Everything below is what sits behind that. What changes if the standard…		2	2.7k	9mo
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club number needed to treat risk of bias journal club effect size Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Writing it up because I had to work it out twice and would rather nobody else did. The question about STEP 4 that I actually want…	+81	90	54k	9mo
[2026 update] Splitting an overlong document into two Documentation › Wiki requests maintainership review date wiki post promoted to docs Solved Closed Splitting an overlong document into two — setting out what I have, and where I think it stops being reliable. Collecting what is known about Splitting an overlong document in one place, because it is…	+44	48	7k	9mo
Revisiting: German, French and Dutch differences, compared Regional › European Union personal import formulary EMA cost per milligram Posting this under the heading it deserves: Revisiting: German, French and Dutch differences, compared Everything below is what sits behind that. I have spent a fortnight trying to pin German down and I want…	+90	99	32k	9mo
Why "any advice?" is the least effective ending for a post — the long version Start Here › How to Ask guidelines site feedback worked example onboarding Solved Asking directly, because I could not find a straight answer: Why "any advice?" is the least effective ending for a post — the long version Counting it rather than describing it, because the count is the part…	+77	83	1.6k	9mo
Particulates in a reconstituted solution: identifying the likely source Analytics › Impurities & related substances counter-ion content data table HPLC water content Posting this under the heading it deserves: Particulates in a reconstituted solution: identifying the likely source Everything below is what sits behind that. Something about particulates does not reconcile…	+15	19	13k	9mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A follow-up question about appetite effects that I did not know to ask the first time. The earlier thread…	+86	90	61k	9mo
NHS criteria and how they are applied in practice — the long version Regional › UK & Ireland cost per milligram NHS MHRA Posting this under the heading it deserves: NHS criteria and how they are applied in practice — the long version Everything below is what sits behind that. A narrow question about NHS criteria, deliberately…	+11	15	11k	9mo
Reconciling a supplier certificate with an independent result Sourcing › Vendor reports third-party testing Janoshik Analytical certificate of analysis Reconciling a supplier certificate with an independent result — setting out what I have, and where I think it stops being reliable. Reconciling a supplier certificate: setting out the arithmetic in full,…	+18	24	347	9mo
Revisiting: Sample size in a voluntary survey: the selection problem Data & Tools › Datasets data table confounding site feedback observational data Solved Revisiting: Sample size in a voluntary survey: the selection problem — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin Sample size down and I want to…		2	56k	9mo
[2026 update] A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipase & amylase liver enzymes lipid panel Solved Closed On the subject in the title: A single out-of-range value on an otherwise normal panel Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+15	19	53k	9mo
Temperature loggers worth the money Devices › Cold chain cold chain storage freeze-thaw Temperature loggers worth the money — setting out what I have, and where I think it stops being reliable. Something about temperature loggers worth the money does not reconcile and I would like a second pair…	+46	50	8k	9mo
"Should I double up?" — answered once, at length, calmly Practice › Administration subcutaneous injection missed dose injection site reaction "Should I double up?" — answered once, at length, calmly — setting out what I have, and where I think it stops being reliable. A practical question that I suspect has a boring answer, which is why I could not…	+24	28	13k	9mo
Trust level 3 requirements: a clarification Meta › Announcements guidelines site feedback moderation Trust level 3 requirements: a clarification — setting out what I have, and where I think it stops being reliable. Trust level 3 requirements, and specifically the version of it that the documentation does not…	+10	14	7k	9mo
A 10 mg vial reconstituted three different ways, compared — the long version Practice › Reconstitution reconstitution syringe units worked example concentration maths A 10 mg vial reconstituted three different ways, compared — the long version — setting out what I have, and where I think it stops being reliable. Asking about 10 mg vial reconstituted three directly, because…	+146	158	47k	9mo
Aggregated purity results across four services, with caveats Data & Tools › Datasets observational data site feedback data table Posting this under the heading it deserves: Aggregated purity results across four services, with caveats Everything below is what sits behind that. Aggregated purity results across four, from the point of…		3	24k	9mo
[2026 update] Does dual agonism explain the effect size, or is it dose? Compounds › Tirzepatide SURMOUNT programme randomised trial SURPASS programme effect size Solved Asking directly, because I could not find a straight answer: Does dual agonism explain the effect size, or is it dose? A question about dual agonism that I think has a definite answer, unlike most of what I…	+58	63	40k	9mo
Journal club: indirect comparison between two programmes, defended and attacked — one year on Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: indirect comparison between two programmes, defended and attacked — one year on Everything below is what sits behind that. Asking about indirect…	+45	50	3k	9mo
Amylin receptor signalling and satiety Pharmacology › Receptor biology tirzepatide semaglutide amylin analogues Wiki Amylin receptor signalling and satiety Writing it up because I had to work it out twice and would rather nobody else did. Asking about amylin receptor signalling and satiety directly, because I have read four…	+22	26	1.8k	9mo
Dose numbers across compounds are not on the same scale Practice › Dosing & titration titration worked example tirzepatide missed dose Dose numbers across compounds are not on the same scale — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on dose numbers across…		2	1.6k	9mo
Insurance and replacement policies, compared — the long version Sourcing › Logistics shipping cold chain packaging temperature excursion Insurance and replacement policies, compared — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Insurance and replacement policies, deliberately…	+29	33	4.9k	9mo
Revisiting: Gallbladder disease risk with rapid weight loss Clinical › Comorbidities MASH / hepatic steatosis chronic kidney disease PCOS obstructive sleep apnoea Revisiting: Gallbladder disease risk with rapid weight loss Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…		2	2k	9mo
Second pass at: Coverage in the US: a map of the usual obstacles Regional › North America insurance telehealth compounding FDA On the subject in the title: Second pass at: Coverage in the US: a map of the usual obstacles Working notes rather than a conclusion. Two things I would like separated before anyone answers on Coverage,…		4	62k	9mo
A 40-week log with the measurement method stated Outcomes › Progress reports DXA long read data table On the subject in the title: A 40-week log with the measurement method stated Working notes rather than a conclusion. Asking about 40-week log directly, because I have read four threads on it and each…	+87	97	18k	9mo