Latest topics page 29

Posting this under the heading it deserves: Comparing two chromatograms from different laboratories, properly Everything below is what sits behind that. I would like to understand what this number means…

Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Pooling trials with different…

Severe gastroparesis and why this class is a poor fit — one year on — setting out what I have, and where I think it stops being reliable. Asking about Severe gastroparesis directly, because I have read four…

On the subject in the title: Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Working notes rather than a conclusion. A narrow question about Tirzepatide in type 2…

On the subject in the title: Tirzepatide's shorter half-life and its one practical consequence Working notes rather than a conclusion. Documentation question rather than a pharmacological one, but about this…

Documentation that materially improves an appeal's chances — setting out what I have, and where I think it stops being reliable. An honest uncertainty about documentation rather than a disguised assertion. I…

Robustness: the parameters worth deliberately varying Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about robustness, deliberately narrow, because the…

The question in the title: Second pass at: Asking a follow-up: new topic or new reply? I will give what I have already checked below so nobody repeats it. Posting a small dataset on Asking a follow-up. It is…

On the subject in the title: Water content on a certificate and why it changes the arithmetic — what changed since Working notes rather than a conclusion. What changes if the standard account of Water content…

Why mass spectrometry cannot tell you about an epimer — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic and I would like it…

Where the integrator drew the baseline, and how much it moved the number — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three…

Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard…

Asking directly, because I could not find a straight answer: How the vendor documentation pages are maintained, and by whom — what changed since What changes if the standard account of vendor documentation…

On the subject in the title: Cross-border purchase rules within the EU Working notes rather than a conclusion. The question about cross-border purchase rules within that I actually want answered is the second…

Second pass at: A reconstituted vial's beyond-use date and the reasoning behind common figures Writing it up because I had to work it out twice and would rather nobody else did. Something changed and I would…

The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. The question about pooling buys that I actually want answered is the…

On the subject in the title: A preprint whose numbers changed substantially at publication — what changed since Working notes rather than a conclusion. A preprint question rather than a question about the…

Journal club: how we handle discontinuation in obesity trials — what changed since — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it…

Oral versus injectable exposure: comparing apples to a different fruit — setting out what I have, and where I think it stops being reliable. Something about oral versus injectable exposure does not reconcile…

On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion. Proposing that absolute versus relative contraindications deserves a maintained page rather than…

History of disordered eating and why it changes the conversation Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of history of…

Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not…

Posting this under the heading it deserves: Pharmaceutical compounding rules, summarised from primary sources — a second dataset Everything below is what sits behind that. Asking what a regulator's document…

On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…

Second pass at: Two scans six weeks apart on different machines: a cautionary tale Writing it up because I had to work it out twice and would rather nobody else did. A question about measurement precision…

Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Retatrutide phase 2 in type that I did…

On the subject in the title: Second pass at: Programming during a large energy deficit Working notes rather than a conclusion. The question about Programming during a large energy that I actually want…

What a purity-only report leaves out — that is the question, and I have not found it answered plainly anywhere I have looked. Purity-only: setting out the arithmetic in full, because I have had to do it twice…

Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. Reading back through what has been written here about…

Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. A follow-up question about Constipation management that I did not know to ask the…