Latest topics page 30

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 30 of 52

Topic	Participants	Replies	Views	Activity
[2026 update] How much of the diluent volume the powder itself displaces Practice › Reconstitution reconstitution worked example syringe units Wiki Closed The question in the title: How much of the diluent volume the powder itself displaces I will give what I have already checked below so nobody repeats it. Writing this out with the numbers in it, because…	+89	100	3.2k	8mo
Thyroid function tests during substantial weight change Clinical › Bloodwork lipase & amylase HbA1c liver enzymes eGFR & renal function Closed Posting this under the heading it deserves: Thyroid function tests during substantial weight change Everything below is what sits behind that. I was wrong about thyroid function tests during substantial in a…	+136	149	3.3k	8mo
Sequence verification for an obscure compound: how it is done — what changed since Compounds › Other compounds custom synthesis needs a source mislabelling On the subject in the title: Sequence verification for an obscure compound: how it is done — what changed since Working notes rather than a conclusion. What changes if the standard account of Sequence…	+100	108	1.3k	8mo
Coming back to: Injection-site reactions: describing them precisely enough to be useful Practice › Side effects hair shedding fatigue constipation nausea On the subject in the title: Injection-site reactions: describing them precisely enough to be useful Working notes rather than a conclusion. Reading back through what has been written here about…	+21	25	22k	8mo
The anatomy of a question that gets answered within an hour — the long version Start Here › How to Ask onboarding beginner friendly guidelines The anatomy of a question that gets answered within an hour — the long version Writing it up because I had to work it out twice and would rather nobody else did. Question in the title. Context below, and I…	+131	142	49k	8mo
How this community escalates rather than diagnoses Safety › Adverse events delayed gastric emptying hypoglycaemia vomiting gallbladder Solved How this community escalates rather than diagnoses — that is the question, and I have not found it answered plainly anywhere I have looked. Community escalates, and specifically the version of it that the…		4	51k	8mo
Biological variation versus analytical imprecision — does this still hold? Clinical › Bloodwork HbA1c eGFR & renal function thyroid function lipid panel Solved Closed The question in the title: Biological variation versus analytical imprecision — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Biological…		2	1.8k	8mo
Revisiting: Aggregates and why a purity assay may miss them entirely Analytics › Impurities & related substances endotoxin testing HPLC counter-ion content water content Solved Posting this under the heading it deserves: Revisiting: Aggregates and why a purity assay may miss them entirely Everything below is what sits behind that. I would like to disagree carefully with the settled…	+48	53	918	8mo
What a confidence interval means, from scratch — the long version Research Methods › Statistics effect size worked example confounding number needed to treat The question in the title: What a confidence interval means, from scratch — the long version I will give what I have already checked below so nobody repeats it. Asking about confidence interval directly,…	+16	20	2.3k	8mo
Managing an unplanned gap in supply — what changed since Access › Shortages compounding FDA formulary On the subject in the title: Managing an unplanned gap in supply — what changed since Working notes rather than a conclusion. What changes if the standard account of Managing an unplanned gap is wrong? I ask…	+114	124	54k	8mo
Sleep quality changes during weight loss — what changed since Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Sleep quality changes during weight loss — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Sleep quality changes…	+68	74	10k	8mo
What a reversed-phase purity number actually is — the long version Analytics › HPLC & UHPLC gradient method system suitability HPLC UV & DAD detection Solved What a reversed-phase purity number actually is — the long version I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means…		2	15k	8mo
Freeze-thaw and why one cycle is not the same as five Practice › Storage & stability beyond-use date freeze-thaw cloudy or discoloured solution storage On the subject in the title: Freeze-thaw and why one cycle is not the same as five Working notes rather than a conclusion. Two things I would like separated before anyone answers on freeze-thaw, because they…	+21	25	41k	8mo
Bleeding at the injection site: normal, and what to do about it Practice › Administration injection site reaction aseptic technique subcutaneous injection injection site rotation Solved Bleeding at the injection site: normal, and what to do about it — setting out what I have, and where I think it stops being reliable. Something changed and I would like to know whether it should have. Same…		3	59k	8mo
LOD and LOQ: definitions people get wrong Analytics › Method validation precision & repeatability recovery stability-indicating method linearity Closed LOD and LOQ: definitions people get wrong — setting out what I have, and where I think it stops being reliable. What changes if the standard account of LOD and LOQ is wrong? I ask because I have been treating…		2	43k	8mo
A calculator that gives a right answer to the wrong question — does this still hold? Data & Tools › Calculators worked example concentration maths syringe units site feedback Solved Under review A calculator that gives a right answer to the wrong question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the calculation with the…	+23	27	62k	8mo
A comparison of home results against a laboratory result on the same vial Analytics › Home & field testing documentation quality ELISA third-party testing Posting this under the heading it deserves: A comparison of home results against a laboratory result on the same vial Everything below is what sits behind that. Comparison of home results against: setting out…	+61	65	35k	8mo
[2026 update] Scheduled maintenance and what will be unavailable Meta › Announcements trust levels site feedback guidelines Posting this under the heading it deserves: Scheduled maintenance and what will be unavailable Everything below is what sits behind that. Scheduled maintenance: setting out the arithmetic in full, because I…	+18	22	400	8mo
Progressive overload when the scale is falling Nutrition & Training › Resistance training fatigue DXA lean mass loss Posting this under the heading it deserves: Progressive overload when the scale is falling Everything below is what sits behind that. Trying to establish the boundary conditions on progressive overload. The…	+4	8	14k	8mo
Lurking for two months before posting: was that the right call? Start Here › Welcome guidelines trust levels beginner friendly Asking directly, because I could not find a straight answer: Lurking for two months before posting: was that the right call? Question in the title. Context below, and I have tried to include the things people…	+66	71	11k	8mo
Pen dose counters: what a click does and does not guarantee Devices › Pens & autoinjectors missed dose subcutaneous injection storage Under review On the subject in the title: Pen dose counters: what a click does and does not guarantee Working notes rather than a conclusion. Pen dose counters — I have the observation and I do not trust my interpretation…	+116	122	1.6k	8mo
Titles that describe the question, not the situation Start Here › How to Ask onboarding site feedback guidelines worked example Closed Titles that describe the question, not the situation — setting out what I have, and where I think it stops being reliable. A narrow question about titles, deliberately narrow, because the broad version has…	+137	153	22k	8mo
Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC peak integration UV & DAD detection system suitability HPLC On the subject in the title: Detection wavelength and why 214 nm and 280 nm disagree Working notes rather than a conclusion. I would like to disagree carefully with the settled view on detection wavelength,…	+78	84	1.7k	8mo
[2026 update] What steady state means for the decision to escalate Practice › Dosing & titration tirzepatide worked example semaglutide missed dose The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. Asking about steady state directly, because I have read four…	+127	137	32k	8mo
High-resolution MS on aggregates and what it can see Analytics › Mass spectrometry charge states counter-ion content high-resolution MS Posting this under the heading it deserves: High-resolution MS on aggregates and what it can see Everything below is what sits behind that. Something about high-resolution does not reconcile and I would like…	+117	123	6.5k	8mo
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Compounds › Tirzepatide tirzepatide SURPASS programme effect size randomised trial Closed Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Writing it up because I had to work it out twice and would rather nobody else did. I would like to know what people here…	+89	101	32k	8mo
Long-time reader, first-time poster Lounge › Introductions beginner friendly onboarding On the subject in the title: Long-time reader, first-time poster Working notes rather than a conclusion. Trying to work out what would count as evidence on long-time reader, before collecting any. This is the…	+15	19	2.5k	8mo
Follow-up: The lowest dose that does anything: is that a real question? Practice › Dosing & titration worked example missed dose tirzepatide dose reduction Closed The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…	+70	75	12k	8mo
EMA product information as a primary source Regional › European Union personal import formulary EMA Posting this under the heading it deserves: EMA product information as a primary source Everything below is what sits behind that. Something about EMA product information does not reconcile and I would like a…	+70	74	7k	8mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo