Newest first

New topics page 14

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 14 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: How to disagree with an answer you were given, well Start Here › How to Ask onboarding worked example guidelines site feedback How to disagree with an answer you were given, well I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title and the context underneath, in the order the…		2	16k	30d
CJC-1295 with and without DAC: what the modification does Compounds › Secretagogues & GH axis needs a source tesamorelin CJC-1295 GHRP class On the subject in the title: CJC-1295 with and without DAC: what the modification does Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a compound…	+117	123	5.6k	22h
Follow-up: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing disputed documentation quality Solved On the subject in the title: Patterns that reliably precede a problem, documented Working notes rather than a conclusion. A follow-up question about Patterns that I did not know to ask the first time. The…		2	70	1d
Preservatives: function, testing, and limits — one year on Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage bacteriostatic water Wiki On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…	+28	32	437	8d
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about widely repeated…	+89	94	5.9k	2h
Coming back to: Light exposure: how much protection is proportionate? Practice › Storage & stability temperature excursion cold chain freeze-thaw cloudy or discoloured solution Asking directly, because I could not find a straight answer: Light exposure: how much protection is proportionate? Reading back through what has been written here about Light exposure, three questions come up…	+5	10	13k	2d
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. A preprint question rather than a question about the finding in it. The…	+7	11	26k	4mo
When a dose reduction is the correct response to a side effect Practice › Dosing & titration dose reduction tirzepatide titration missed dose Solved When a dose reduction is the correct response to a side effect — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have…	+38	42	2.7k	19h
Revisiting: Maintainer handover: how it works Meta › Wiki maintenance maintainership review date wiki post moderation Solved Revisiting: Maintainer handover: how it works Writing it up because I had to work it out twice and would rather nobody else did. Maintainer handover keeps being re-asked here and I think that is because the…	+53	57	664	4mo
Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration tirzepatide dose reduction titration semaglutide Solved Why "dose equivalence" between different incretin analogues is a weak concept I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this…	+124	133	11k	5mo
Prescription portability between countries — the long version Access › International EMA NHS telehealth On the subject in the title: Prescription portability between countries — the long version Working notes rather than a conclusion. A narrow question about Prescription portability between countries,…		2	182	21h
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. Working notes on Regional warehouse stock versus direct rather than a…	+135	147	32k	2d
What other technical communities get right that we do not Lounge › Off topic beginner friendly long read Wiki What other technical communities get right that we do not — that is the question, and I have not found it answered plainly anywhere I have looked. A digression I have been saving for the right category. It is…	+2	6	23k	5h
Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data tesamorelin needs a source GHRP class Wiki Asking directly, because I could not find a straight answer: Why this subcategory is stricter about sourcing than most A comparison question rather than a question about one compound. Two things in the same…	+48	52	617	21d
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Posting the method first, because I know what the first three…	+10	14	13k	5mo
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. A narrow question about headache, deliberately narrow, because the broad…	+68	73	1.3k	12h
About the Special populations category Clinical › Special populations older adults pregnancy & planning adolescents Pinned Wiki Older adults, pregnancy and pregnancy planning, adolescents, renal and hepatic impairment, bariatric surgery history. This post is a community wiki: any member at trust level 3 or above can edit it, and every…		4	3k	4mo
Resolution and tailing factor: real acceptance criteria Analytics › HPLC & UHPLC HPLC gradient method peak integration system suitability Resolution and tailing factor: real acceptance criteria Writing it up because I had to work it out twice and would rather nobody else did. Asking about resolution and tailing factor on behalf of the question…		2	15k	1mo
Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club journal club estimand randomised trial Journal club: orforglipron phase 2 and the non-peptide question Writing it up because I had to work it out twice and would rather nobody else did. Orforglipron phase 2, and specifically the version of it that…	+120	132	13k	1d
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Coming back to: Why I now write the concentration on the vial in marker Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example The question in the title: Why I now write the concentration on the vial in marker I will give what I have already checked below so nobody repeats it. Writing this out with the numbers in it, because…	+8	12	4.3k	1d
About the Doc review category Documentation › Doc review wiki post promoted to docs citation check Pinned Wiki Review of drafts and revisions before and after promotion. Every promotion is discussed in public. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	25k	4mo
Mass error in ppm: the arithmetic and the caveat Analytics › Mass spectrometry LC-MS high-resolution MS MALDI-TOF counter-ion content Solved Mass error in ppm: the arithmetic and the caveat Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+108	125	1.5k	5mo
[2026 update] Composite endpoints and the component doing the work Evidence › Trials surrogate endpoints discontinuation & dropout estimand On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…	+76	87	994	3mo
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Compounds › Retatrutide randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? An honest uncertainty about TRIUMPH rather than a…	+43	47	5.5k	just now
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin nausea profile of…	+70	76	3k	4mo
Second pass at: Identical chromatograms across two different lots Sourcing › Red flags disputed mislabelling moderation Posting this under the heading it deserves: Second pass at: Identical chromatograms across two different lots Everything below is what sits behind that. Something about Identical chromatograms does not…	+81	93	13k	4mo
About the HPLC & UHPLC category Analytics › HPLC & UHPLC HPLC peak integration gradient method Pinned Wiki Reversed-phase separations, gradients, columns, integration, and reading a chromatogram properly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	137	18h
Type 2 diabetes and the largest part of the evidence base Clinical › Comorbidities chronic kidney disease obstructive sleep apnoea type 2 diabetes MASH / hepatic steatosis Posting this under the heading it deserves: Type 2 diabetes and the largest part of the evidence base Everything below is what sits behind that. Trying to work out what would count as evidence on type 2…	+81	89	2.9k	3mo
A genuinely late dose: what the labelling says and what people do Practice › Administration injection site rotation missed dose needle gauge & length injection site reaction On the subject in the title: A genuinely late dose: what the labelling says and what people do Working notes rather than a conclusion. A methods question rather than a substantive one, about genuinely late…		2	18k	5mo