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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 19 of 40

Topic	Participants	Replies	Views	Activity
[2026 update] Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Closed Posting this under the heading it deserves: Evidence quality in the secretagogue literature: an honest assessment Everything below is what sits behind that. I have spent a fortnight trying to pin Evidence…	+14	18	3.1k	6mo
Second pass at: Temperature logging at home: what is worth the effort Practice › Storage & stability temperature excursion cloudy or discoloured solution freeze-thaw cold chain Posting this under the heading it deserves: Second pass at: Temperature logging at home: what is worth the effort Everything below is what sits behind that. Posting a small dataset on Temperature logging. It…	+4	8	29k	1mo
Sulfonylureas: the interaction most worth taking seriously Practice › Interactions needs a source metformin insulin Sulfonylureas: the interaction most worth taking seriously Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about sulfonylureas rather than a disguised…	+4	8	38k	6h
[2026 update] Publication patterns in the BPC-157 literature, examined Compounds › Repair & healing peptides BPC-157 observational data TB-500 Solved Publication patterns in the BPC-157 literature, examined Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a question about a…	+15	19	11k	4mo
About the Other compounds category Compounds › Other compounds research use only custom synthesis needs a source Pinned Wiki Closed Anything not covered by a dedicated subcategory, including research-use-only material with no human data. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+8	12	51k	7mo
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Practice › Administration injection site reaction needle gauge & length aseptic technique injection site rotation Rotating between abdomen, thigh and upper arm: absorption differences — one year on — setting out what I have, and where I think it stops being reliable. Asking about Rotating between abdomen directly,…	+82	102	24k	just now
Follow-up: Search filters: what is missing Meta › Site feedback guidelines site feedback moderation On the subject in the title: Search filters: what is missing Working notes rather than a conclusion. A follow-up question about Search filters that I did not know to ask the first time. The earlier thread…	+121	141	1.6k	29d
Pinch or no pinch, and how needle length changes the answer — the long version Practice › Administration injection site rotation injection site reaction missed dose aseptic technique On the subject in the title: Pinch or no pinch, and how needle length changes the answer — the long version Working notes rather than a conclusion. A narrow question about Pinch, deliberately narrow, because…	+75	79	1.5k	1mo
Revisiting: A page that has drifted out of date and needs a maintainer Documentation › Wiki requests maintainership promoted to docs wiki post review date Revisiting: A page that has drifted out of date and needs a maintainer Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the…	+112	119	8.8k	5mo
Preprint servers and what screening they do Evidence › Preprints preprint effect size needs a source Preprint servers and what screening they do — setting out what I have, and where I think it stops being reliable. A preprint question rather than a question about the finding in it. The manuscript is on a…	+95	106	5.6k	4mo
Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? Compounds › Repair & healing peptides needs a source preprint BPC-157 Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. The question about Analytical…	+28	33	1.6k	1mo
When your prescriber and the evidence disagree Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes When your prescriber and the evidence disagree — that is the question, and I have not found it answered plainly anywhere I have looked. What changes if the standard account of prescriber is wrong? I ask…	+14	18	273	2d
The decimal-point error, and the habit that catches it Practice › Reconstitution syringe units concentration maths worked example bacteriostatic water The decimal-point error, and the habit that catches it Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about decimal-point error rather than a…	+110	121	10k	7mo
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Practice › Storage & stability beyond-use date freeze-thaw cloudy or discoloured solution storage Closed On the subject in the title: Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Working notes rather than a conclusion. The question about Adsorptive losses that I…	+77	87	58k	4mo
About the Regulatory category Sourcing › Regulatory research use only compounding FDA Pinned Wiki Research-use-only status, compounding rules, import restrictions, and the primary documents behind them. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	49k	4mo
Revisiting: The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports batch & lot numbers Janoshik Analytical documentation quality third-party testing Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…	+100	108	57k	1d
Adjudicated events and why the definition matters Evidence › Trials estimand intention to treat discontinuation & dropout surrogate endpoints Under review On the subject in the title: Adjudicated events and why the definition matters Working notes rather than a conclusion. A follow-up question about adjudicated events that I did not know to ask the first time.…		2	4.5k	2mo
Reading U-100 graduations, with a conversion table — one year on Devices › Syringes & needles syringe units needle gauge & length worked example subcutaneous injection Reading U-100 graduations, with a conversion table — one year on Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on…	+3	7	662	4mo
Ultrasound and skinfolds: operator dependence in practice — what changed since Outcomes › Body composition data table DXA bioimpedance lean mass loss Posting this under the heading it deserves: Ultrasound and skinfolds: operator dependence in practice — what changed since Everything below is what sits behind that. What changes if the standard account of…	+32	37	7.4k	3mo
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? Data & Tools › Datasets data table confounding observational data Solved Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. An honest uncertainty about…	+14	18	3.4k	2mo
Introducing myself: pharmacist, sceptic, reluctant participant Lounge › Introductions onboarding beginner friendly Introducing myself: pharmacist, sceptic, reluctant participant Writing it up because I had to work it out twice and would rather nobody else did. Introducing myself before I ask anything, since the welcome…	+13	17	23k	2mo
[2026 update] Availability by country, dated, with primary sources Access › International MHRA NHS telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+40	45	14k	4mo
Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? Evidence › Journal club estimand randomised trial number needed to treat effect size Solved Closed Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A narrow question about semaglutide…		3	28k	6mo
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Working notes on selection rather than a conclusion. I would rather post the…		2	55k	7mo
Aggregates and why a purity assay may miss them entirely Analytics › Impurities & related substances water content counter-ion content forced degradation HPLC Aggregates and why a purity assay may miss them entirely Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on…	+61	69	2.9k	6mo
[2026 update] Whether protein timing matters at a large deficit Nutrition & Training › Protein & intake lean mass loss fatigue constipation micronutrients Whether protein timing matters at a large deficit — setting out what I have, and where I think it stops being reliable. A follow-up question about Whether protein timing that I did not know to ask the first…	+4	8	46k	7mo
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators concentration maths site feedback syringe units On the subject in the title: Bug report: the reconstitution calculator and a rounding edge case Working notes rather than a conclusion. Posting the calculation with the inputs, so that somebody can disagree…	+58	63	24k	5mo
[2026 update] Conference abstracts as evidence: the weakest common citation Evidence › Preprints needs a source effect size preprint risk of bias Closed Conference abstracts as evidence: the weakest common citation — setting out what I have, and where I think it stops being reliable. Reading an unrefereed manuscript properly, and asking whether I am doing it…		2	48k	7mo
Lean mass preservation: what the evidence supports — does this still hold? Outcomes › Body composition bioimpedance lean mass loss data table DXA Asking directly, because I could not find a straight answer: Lean mass preservation: what the evidence supports — does this still hold? What changes if the standard account of Lean mass preservation is wrong?…	+112	122	5.2k	20h
Revisiting: Sample handling between despatch and injection Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Revisiting: Sample handling between despatch and injection Everything below is what sits behind that. Reading back through what has been written here about Sample…	+5	9	1.1k	6mo