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1,535 topics · page 18 of 40

Topic	Participants	Replies	Views	Activity
Temperature indicator cards: worth asking for? Sourcing › Logistics customs packaging temperature excursion shipping Asking directly, because I could not find a straight answer: Temperature indicator cards: worth asking for? Two things I would like separated before anyone answers on temperature indicator cards, because they…	+2	6	116	3mo
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. The question about solubility limits that I actually want answered is the…	+11	15	34k	20h
Coming back to: Training through a dose escalation week Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Training through a dose escalation week Working notes rather than a conclusion. What changes if the standard account of Training through a dose escalation is wrong? I ask because…	+68	74	46k	4mo
Second pass at: Submitting a sample: the process end to end Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Solved Second pass at: Submitting a sample: the process end to end Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Submitting a sample. It is mine, it is…	+12	16	41k	4mo
[2026 update] Reading a supplementary appendix and finding the interesting part Evidence › Trials estimand intention to treat open label surrogate endpoints On the subject in the title: Reading a supplementary appendix and finding the interesting part Working notes rather than a conclusion. Collecting what is known about Reading a supplementary appendix in one…	+39	44	8.2k	5mo
Follow-up: Reconciling a label claim with a content assay Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Reconciling a label claim with a content assay Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Reconciling a label claim that I did not know to…	+26	30	6.5k	14d
What a stability-indicating method is and how you demonstrate one Analytics › Method validation linearity precision & repeatability LOD & LOQ Asking directly, because I could not find a straight answer: What a stability-indicating method is and how you demonstrate one Posting a small dataset on stability-indicating method. It is mine, it is…		4	57k	6mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. A narrow question about Absolute versus relative contraindications, deliberately…	+80	85	7.4k	3mo
Peer-to-peer review: what actually happens on the call Access › Insurance & coverage prior authorisation appeals formulary On the subject in the title: Peer-to-peer review: what actually happens on the call Working notes rather than a conclusion. The question about peer-to-peer review that I actually want answered is the second…		2	1.2k	1d
Documenting a payment dispute without naming and shaming Sourcing › Payments documentation quality research use only payments Documenting a payment dispute without naming and shaming — setting out what I have, and where I think it stops being reliable. A payments question, with the mechanics separated from the money. What I would…	+5	9	9.8k	2mo
Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry cloudy or discoloured solution counter-ion content sterile water bacteriostatic water On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. I was wrong about adsorption in a thread last spring and I would like to correct it…	+13	17	4.3k	5mo
About the Announcements category Meta › Announcements guidelines trust levels moderation Pinned Wiki Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+3	7	8.7k	4h
Vomiting: when it is expected and when it is a reason to stop Practice › Side effects constipation nausea fatigue Solved Posting this under the heading it deserves: Vomiting: when it is expected and when it is a reason to stop Everything below is what sits behind that. Reporting something rather than asking about it, in case…	+116	124	43k	7mo
About the Calculators category Data & Tools › Calculators worked example concentration maths syringe units Pinned Wiki Reconstitution, dose equivalence, titration planning, mass-error checking and storage lookup. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+2	7	733	5mo
[2026 update] Journal club: FLOW and the renal composite, component by component Evidence › Journal club journal club randomised trial estimand Journal club: FLOW and the renal composite, component by component Writing it up because I had to work it out twice and would rather nobody else did. A question about what the numbers mean rather than what…		2	21k	9d
What to include when your question involves a chromatogram Start Here › How to Ask guidelines beginner friendly worked example Solved What to include when your question involves a chromatogram I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+49	54	58k	6mo
Coming back to: Reconstitution volumes that produce round numbers, tabulated Practice › Reconstitution concentration maths syringe units bacteriostatic water dead volume On the subject in the title: Reconstitution volumes that produce round numbers, tabulated Working notes rather than a conclusion. Writing this out with the numbers in it, because "roughly" is how these go…		2	24k	6mo
Pregnancy and pregnancy planning: contraindication and washout Clinical › Special populations pregnancy & planning bariatric surgery history chronic kidney disease disordered eating Closed Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. Pregnancy and pregnancy planning: setting out the…	+111	122	2.4k	3mo
Reverse causation in a cohort study of weight and outcome Evidence › Study critique disputed observational data effect size On the subject in the title: Reverse causation in a cohort study of weight and outcome Working notes rather than a conclusion. Posting a small dataset on reverse causation. It is mine, it is uncontrolled, and…	+10	14	11k	7mo
A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipid panel HbA1c liver enzymes lipase & amylase Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+70	75	20k	6d
[2026 update] Reflux appearing for the first time at a dose step Practice › Side effects constipation delayed gastric emptying nausea vomiting Posting this under the heading it deserves: Reflux appearing for the first time at a dose step Everything below is what sits behind that. Reporting something rather than asking about it, in case the pattern…		2	980	7mo
What "verified" means on our vendor pages, stated narrowly Sourcing › Vendor reports batch & lot numbers disputed documentation quality third-party testing What "verified" means on our vendor pages, stated narrowly — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how a record should be read rather than…	+27	31	27k	7mo
Coming back to: Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics missed dose semaglutide worked example Closed Posting this under the heading it deserves: Washout: how long is long enough, and for what purpose Everything below is what sits behind that. A narrow question about Washout, deliberately narrow, because the…	+128	139	3k	3mo
Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide amylin analogues Closed Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Trying to work out what would…	+21	25	45k	7mo
Measurement error in home scales, with a worked standard deviation — the long version Research Methods › Statistics number needed to treat worked example heterogeneity effect size Solved On the subject in the title: Measurement error in home scales, with a worked standard deviation — the long version Working notes rather than a conclusion. A narrow question about Measurement error in home…	+96	105	2k	2mo
Coming back to: Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import MHRA NHS cost per milligram Private prescribing in the UK: what is actually involved Writing it up because I had to work it out twice and would rather nobody else did. I would like to know what people here actually do about Private…	+62	67	2.1k	6mo
Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability temperature excursion cold chain freeze-thaw On the subject in the title: Storing lyophilised material long term: what governs the shelf life Working notes rather than a conclusion. I have spent a fortnight trying to pin storing lyophilised material…	+83	90	1k	5mo
Request declined, with reasoning — what changed since Meta › Feature requests wiki post site feedback translation Posting this under the heading it deserves: Request declined, with reasoning — what changed since Everything below is what sits behind that. What changes if the standard account of Request declined is wrong?…	+34	38	9.4k	2mo
Personal import allowances, compared Access › International EMA MHRA telehealth personal import Wiki On the subject in the title: Personal import allowances, compared Working notes rather than a conclusion. I have spent a fortnight trying to pin personal import allowances down and I want to set out where I…	+5	9	3.2k	7mo
About the Bloodwork category Clinical › Bloodwork HbA1c lipid panel eGFR & renal function Pinned Wiki Panels, reference intervals, biological variation, and resisting the urge to over-read one result. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+4	8	4.4k	3mo